Wound dehiscence in enhanced recovery after open radical cystectomy: A meta-analysis.

A meta-analysis study to assess the outcome of enhanced recovery (ER) after radical cystectomy (RC) on wound dehiscence was performed. A comprehensive literature examination till January 2023 was implemented and 1457 linked studies were appraised. The picked studies contained 772 open RC subjects in the picked studies' baseline, 436 of them were enhanced recovery after RC, and 336 were open RC. Odds ratio (OR) in addition to 95% confidence intervals (CIs) were used to calculate the consequence of enhanced recovery after RC on wound dehiscence after open RC by the dichotomous styles and a fixed or random model. The ER after RC caused significantly lower wound dehiscence (OR, 0.51; 95% CI, 0.30-0.89, P = .02) with low heterogeneity (I2  = 46%) compared with open RC. The ER after RC caused significantly lower wound dehiscence compared with open RC. Thorough precaution should be taken when commerce with the consequences because a limited number of studies were found and selected for this meta-analysis.

Benign prostatic hyperplasia wound after surgical removal in subjects on anticoagulant or antiplatelet therapy: A meta-analysis.

We performed a meta-analysis to evaluate the safety of benign prostatic hyperplasia wound after surgical removal in subjects on anticoagulant or antiplatelet therapy. A systematic literature search up to December 2021 was done and 19 studies included 5715 benign prostatic hyperplasia subjects at the start of the study; 1501 of them were on anticoagulant/antiplatelet therapy, and 4214 were control. We calculated the odds ratio (OR) and mean difference (MD) with 95% confidence intervals (CIs) to evaluate the safety of benign prostatic hyperplasia wound after surgical removal in subjects on anticoagulant or antiplatelet therapy by the dichotomous or continuous methods with a random or fixed-influence model. Anticoagulant/antiplatelet therapy had significantly higher bleeding complication (OR, 1.88; 95% CI, 1.36-2.60, P < .001), higher blood transfusion (OR, 2.15; 95% CI, 1.63-2.83, P < .001), lower operation time (MD, -3.53; 95% CI, -6.80-0.27, P = .03), higher catheterization time (MD, 0.30 95% CI, 0.06-0.53, P = .01), longer length of hospital stay (MD, 0.82; 95% CI, 0.37-1.26, P < .001) and higher thromboembolic events (OR, 2.88; 95% CI, 1.26-6.62, P = .01) compared to control in benign prostatic hyperplasia subjects. Anticoagulant/antiplatelet therapy had a significantly higher bleeding complication, higher blood transfusion, lower operation time, higher catheterization time, longer length of hospital stay and higher thromboembolic events compared to control in benign prostatic hyperplasia subjects. Further studies are required.

Investigation on the Energy-Absorbing Properties of Bionic Spider Web Structure.

In recent years, spider webs have received significant attention due to their exceptional mechanical properties, including strength, toughness, elasticity, and robustness. Among these spider webs, the orb web is a prevalent type. An orb web's main framework consists of radial and spiral threads, with elastic and sticky threads used to capture prey. This paper proposes a bionic orb web model to investigate the energy-absorbing properties of a bionic spider web structure. The model considers structural parameters such as radial line length, radial line cross-sectional diameter, number of spiral lines, spiral spacing, and spiral cross-sectional diameter. These parameters are evaluated to assess the energy absorption capability of the bionic spider web structure. Simulation results reveal that the impact of the radial line length and spiral cross-sectional diameter on the energy absorption of the spider web is more significant compared to the radial line cross-sectional diameter, the number of spiral lines, and spiral spacing. Specifically, within a radial line length range of 60-80 mm, the total absorbed energy of a spider web is inversely proportional to the radial line length of the web. Moreover, the number of spiral lines and spiral spacing of the spider web, when within the range of 6-10 turns and 4-5.5 mm, respectively, are proportional to the total energy absorbed. A regression equation is derived to predict the optimal combination of structural parameters for maximum energy absorption. The optimal parameters are determined as follows: radial line length of 63.48 mm, radial line cross-sectional diameter of 0.46 mm, ten spiral lines, spiral spacing of 5.39 mm, and spiral cross-sectional diameter of 0.48 mm.

Effects of Paeoniflorin on the activity of muscle strips, intracellular calcium ion concentration and L­type voltage­sensitive calcium ion channels in the sphincter of Oddi of hypercholesterolemic rabbits.

Sphincter of Oddi dysfunction (SOD) is a benign obstructive disorder predominantly resulting from spasms of the SO. Pharmacological therapies aim to induce SO relaxation; the hypercholesterolemic (HC) rabbit is the only SOD model available for study. In the present study, SO muscle strips, intracellular calcium ion concentrations and the mRNA expression levels of the α1C subunit of the L­type calcium channel in the SO muscle cells of HC rabbits were employed to investigate the effects of paeoniflorin (PF). Alterations in L­type calcium channel α subunit 1C mRNA and protein expression in SO cells with HC following the application of different concentrations of PF were determined by reverse transcription­quantitative polymerase chain reaction and western blotting. The whole cell patch clamp technique was used to observe the effects of different concentrations of paeoniflorin on L­type calcium channel current. The results of the present study demonstrated that PF induced the relaxation of SO muscle strips and reduced the intracellular calcium concentration in the SO muscle cells of HC rabbits. In addition, PF decreased the mRNA expression levels of the α1C subunit of the L­type calcium channel and reduced the L­type calcium channel current in SO cells. These results suggested that the mechanism underlying the relaxation of the SO muscle by PF may be associated with the reduction of calcium ion influx via L­type calcium channels.