RESUMO
BACKGROUND: The aim was to investigate circ-HMGCS1 expression and its correlation with clinical features and survival in cervical cancer (CC) patients. METHODS: This prospective study recruited 100 patients with CC who underwent surgical resection. Circ-HMGCS1 expression was measured by RT-qPCR. Disease-free survival (DFS) and overall survival (OS) were recorded. RESULTS: Circ-HMGCS1 was upregulated in tumor tissues and had a good value in separating tumor tissues from normal tissues. Circ-HMGCS1 expression in tumor tissues was positively correlated with tumor size, lymph node metastasis, and FIGO stage. High circ-HMGCS1 expression predicted worse DFS and OS. CONCLUSIONS: circ-HMGCS1 serves as an indicator of survival and prognosis in CC patients.
Assuntos
RNA Circular , Neoplasias do Colo do Útero , Feminino , Humanos , Hidroximetilglutaril-CoA Sintase , Metástase Linfática/fisiopatologia , Prognóstico , Estudos Prospectivos , RNA Circular/genética , RNA Circular/metabolismo , Neoplasias do Colo do Útero/diagnóstico , Neoplasias do Colo do Útero/genética , Neoplasias do Colo do Útero/metabolismo , Intervalo Livre de Doença , Adulto , Pessoa de Meia-Idade , Regulação para Cima , Valor Preditivo dos TestesRESUMO
Single organic small molecule-based nanoparticles (CNPs) with strong responses within the NIR-II (1000-1350 nm) bio-window were prepared, and successfully applied as a highly efficient photothermal antibacterial agent for the first time. CNPs exhibit an outstanding bacteria inhibition efficiency of almost 100% against Staphylococcus aureus (S. aureus) with a high photothermal conversion efficiency (PTCE) of circa 49% under NIR-II laser irradiation (1064 nm) for 8 min.
Assuntos
Nanopartículas , Staphylococcus aureus , Antibacterianos/farmacologia , Fototerapia , Terapia FototérmicaRESUMO
Photothermal therapy (PTT) has received constant attention as an efficient cancer therapy method due to locally selective treatment, which is not affected by the tumor microenvironment. In this study, a novel 880 nm near-infrared (NIR) laser-triggered photothermal agent (PTA), 3TT-IC-4Cl, was used for PTT of a tumor in deep tissue. Folic acid (FA) conjugated amphiphilic block copolymer (folic acid-polyethylene glycol-poly (ß-benzyl-L-aspartate)10, FA-PEG-PBLA10) was employed to encapsulate 3TT-IC-4Cl by nano-precipitation to form stable nanoparticles (TNPs), and TNPs exhibit excellent photothermal stability and photothermal conversion efficiency. Furthermore, the in vitro results showed TNPs display excellent biocompatibility and significant phototoxicity. These results suggest that 880 nm triggered TNPs have great potential as effective PTAs for photothermal therapy of tumors in deep tissue.
RESUMO
Multiple kinds of Artificial Skin Substitute are now available. However, except for the Homo Skin Graft there is no Artificial Skin Substitute that can be used as permanent Artificial Skin Substitute. During the past 20 years, more and more scholars around the world have expressed increased interests in the research and development of Artificial Skin Graft that can be utilized as satisfying permanent Artificial Skin Substitute. We conducted our research on the biological evaluation of medical devices of Collagen-Chitosan(C-C) Artificial Skin Substitute according to the National Standard (GB/T16886. 1-1997). The following experiments were conducted: (1)Cytotoxicity, (2)Systemic toxicity(acute toxicity), (3)Haemocompatibility, (4)Sensitization, (5)Intracutaneous reactivity, (6)Pyrogen test, (7)Genotoxicity. The experiment results demonstrate that all biological functional indexes of the Artificial Skin Graft meet the National Standards. Therefore, we conclude that C-C Artificial Skin Graft is characteristic of good biological compatibility. It is non-irritant and has no systemic and cellular toxicity, no genotoxicity, no pyrogen, and no allergen.