Detalhe da pesquisa
1.
A novel small molecule approach for the treatment of propionic and methylmalonic acidemias.
Mol Genet Metab
; 133(1): 71-82, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33741272
2.
A Phase IIa Study Evaluating Safety, Pharmacokinetics, and Antiviral Activity of GSK2838232, a Novel, Second-generation Maturation Inhibitor, in Participants With Human Immunodeficiency Virus Type 1 Infection.
Clin Infect Dis
; 71(5): 1255-1262, 2020 08 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-31769793
3.
Discovery of a novel and potent class of anti-HIV-1 maturation inhibitors with improved virology profile against gag polymorphisms.
Bioorg Med Chem Lett
; 27(12): 2689-2694, 2017 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28454672
4.
Inhibition of the ribonuclease H activity of HIV-1 reverse transcriptase by GSK5750 correlates with slow enzyme-inhibitor dissociation.
J Biol Chem
; 289(23): 16270-7, 2014 Jun 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-24719329
5.
Antiviral characteristics of GSK1265744, an HIV integrase inhibitor dosed orally or by long-acting injection.
Antimicrob Agents Chemother
; 59(1): 397-406, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25367908
6.
Naphthyridinone (NTD) integrase inhibitors 4. Investigating N1 acetamide substituent effects with C3 amide groups.
Bioorg Med Chem Lett
; 24(14): 3104-7, 2014 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24908608
7.
Choosing the right antibody for resistin-like molecule (RELM/FIZZ) family members.
Histochem Cell Biol
; 139(4): 605-13, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23076260
8.
Naphthyridinone (NTD) integrase inhibitors: N1 protio and methyl combination substituent effects with C3 amide groups.
Bioorg Med Chem Lett
; 23(2): 422-5, 2013 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23245515
9.
Human cardiovascular disease model predicts xanthine oxidase inhibitor cardiovascular risk.
PLoS One
; 18(9): e0291330, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37682977
10.
Dolutegravir (S/GSK1349572) exhibits significantly slower dissociation than raltegravir and elvitegravir from wild-type and integrase inhibitor-resistant HIV-1 integrase-DNA complexes.
Antimicrob Agents Chemother
; 55(10): 4552-9, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21807982
11.
In Vitro antiretroviral properties of S/GSK1349572, a next-generation HIV integrase inhibitor.
Antimicrob Agents Chemother
; 55(2): 813-21, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21115794
12.
Combining symmetry elements results in potent naphthyridinone (NTD) HIV-1 integrase inhibitors.
Bioorg Med Chem Lett
; 21(21): 6461-4, 2011 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21945283
13.
Identification of 2,2-Dimethylbutanoic Acid (HST5040), a Clinical Development Candidate for the Treatment of Propionic Acidemia and Methylmalonic Acidemia.
J Med Chem
; 64(8): 5037-5048, 2021 04 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33848153
14.
Pharmacovirological impact of an integrase inhibitor on human immunodeficiency virus type 1 cDNA species in vivo.
J Virol
; 83(15): 7706-17, 2009 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-19458008
15.
A Phase 1 Study to Assess the Relative Bioavailability, Food Effect, and Safety of a Tablet Formulation of GSK2838232, a Novel HIV Maturation Inhibitor in Healthy Participants After Single and Repeated Doses.
Clin Pharmacol Drug Dev
; 9(8): 972-977, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32558338
16.
Pyrazolopyrimidines and pyrazolotriazines with potent activity against herpesviruses.
Bioorg Med Chem Lett
; 19(19): 5689-92, 2009 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19700316
17.
1,3,4-Oxadiazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 2: SAR of the C5 position.
Bioorg Med Chem Lett
; 19(6): 1807-10, 2009 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19217284
18.
The use of oxadiazole and triazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 1: Establishing the pharmacophore.
Bioorg Med Chem Lett
; 19(6): 1802-6, 2009 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19217781
19.
Pyrazolopyridines with potent activity against herpesviruses: effects of C5 substituents on antiviral activity.
Bioorg Med Chem Lett
; 18(3): 1157-61, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18086523
20.
The safety, tolerability, and pharmacokinetic profile of GSK2838232, a novel 2nd generation HIV maturation inhibitor, as assessed in healthy subjects.
Pharmacol Res Perspect
; 6(4): e00408, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29930812