1.
Bioorg Med Chem Lett
; 21(22): 6788-92, 2011 Nov 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21983447
RESUMO
Based on the anti-hepatitis C activity of 2'-C-methyl-adenosine and 2'-C-methyl-guanosine, a series of new modified purine 2'-C-methyl nucleosides was prepared as potential anti-hepatitis C virus agents. Herein, we report the synthesis of both 6-modified and 2-modified purine 2'-C-methyl-nucleosides along with their anti-HCV replication activity and cytotoxicity in different cells.