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1.
Nature ; 448(7149): 50-3, 2007 Jul 05.
Artigo em Inglês | MEDLINE | ID: mdl-17611535

RESUMO

Hyperion is Saturn's largest known irregularly shaped satellite and the only moon observed to undergo chaotic rotation. Previous work has identified Hyperion's surface as distinct from other small icy objects but left the causes unsettled. Here we report high-resolution images that reveal a unique sponge-like appearance at scales of a few kilometres. Mapping shows a high surface density of relatively well-preserved craters two to ten kilometres across. We have also determined Hyperion's size and mass, and calculated the mean density as 544 +/- 50 kg m(-3), which indicates a porosity of >40 per cent. The high porosity may enhance preservation of craters by minimizing the amount of ejecta produced or retained, and accordingly may be the crucial factor in crafting this unusual surface.

2.
J Urol ; 186(4): 1213-7, 2011 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-21849188

RESUMO

PURPOSE: Serum C-reactive protein has been shown to have prognostic value in localized and metastatic renal cell carcinoma. However, the prognostic value of intratumor C-reactive protein remains unknown. MATERIALS AND METHODS: A total of 95 patients with resected, clinically localized (T1-T4N0M0) clear cell renal cell carcinoma were followed postoperatively. Intratumor C-reactive protein expression was assessed in surgical specimens using immunohistochemical analysis. Patients were categorized by staining intensity into low risk (staining 0 to 1), intermediate risk (staining 2) and high risk (staining 3) groups. Kaplan-Meier and multivariate Cox regression analyses were used to examine overall survival across patient and disease characteristics. Variables examined in multivariate Cox regression analysis included T stage, Fuhrman nuclear grade, tumor size, preoperative serum C-reactive protein and intratumor C-reactive protein staining. RESULTS: Followup extended up to 46 months with a mean (SD) of 29.8 (11.0) months. Twelve patients (12.6%) died during followup. Of all tumors 49.5%, 25.3% and 25.3% were graded by intratumor C-reactive protein staining as low risk (0 to 1), intermediate risk (2) and high risk (3), respectively. After controlling for variables significant on univariate analysis, patients in the high risk (3) group experienced a 27-fold increased risk of overall mortality compared to those in the low risk (0-1) group (HR 27.767, 95% CI 1.488-518.182). After adjusting for tumor staining, preoperative serum C-reactive protein was not a significant predictor of overall survival (p = 0.741). CONCLUSIONS: Intratumor C-reactive protein may be a robust biomarker of prognosis in patients with localized renal cell carcinoma.


Assuntos
Biomarcadores Tumorais/análise , Proteína C-Reativa/análise , Carcinoma de Células Renais/diagnóstico , Neoplasias Renais/diagnóstico , Proteína C-Reativa/metabolismo , Carcinoma de Células Renais/metabolismo , Carcinoma de Células Renais/mortalidade , Carcinoma de Células Renais/patologia , Feminino , Humanos , Imuno-Histoquímica , Estimativa de Kaplan-Meier , Neoplasias Renais/metabolismo , Neoplasias Renais/mortalidade , Neoplasias Renais/patologia , Masculino , Pessoa de Meia-Idade , Prognóstico , Modelos de Riscos Proporcionais , Taxa de Sobrevida
3.
J Urol ; 183(2): 480-5, 2010 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-20006861

RESUMO

PURPOSE: C-reactive protein is an inflammatory biomarker associated with tumor burden and metastasis in renal cell carcinoma. Recent studies suggest that preoperative C-reactive protein predicts metastasis and mortality after nephrectomy for localized renal cell carcinoma. However, these studies dichotomized C-reactive protein (typically 10 mg/l or greater vs less than 10 mg/l). Considering the continuous range of C-reactive protein (less than 1 mg/l to greater than 100 mg/l) we assessed the ability of absolute preoperative C-reactive protein to predict metastases and mortality as a continuous variable. MATERIALS AND METHODS: Patients with clinically localized (T1-T3N0M0) clear cell renal cell carcinoma were followed for 1 year postoperatively. Metastases were identified radiologically and mortality was determined by death certificate. Univariate and multivariate binary logistic regression analyses examined 1-year relapse-free survival and overall relative survival across patient and disease characteristics. RESULTS: Of the 130 patients in this study metastases developed in 24.6% and 10.8% of the patients died. Mean (SD) preoperative C-reactive protein for patients in whom metastases did and did not develop was 89.17 (74.17) and 9.16 (30.62) mg/l, respectively. Mean preoperative C-reactive protein for patients who did and did not die was 102.61 (77.32) and 19.52 (46.10) mg/l, respectively. On multivariate analysis SSIGN score (p <0.001) and preoperative C-reactive protein (B 0.027, SE 0.003, p <0.001) were significant predictors of relapse-free survival, and preoperative platelets (p = 0.009) and preoperative C-reactive protein (B 0.011, SE 0.008, p <0.001) were significant predictors of overall relative survival. CONCLUSIONS: Absolute preoperative C-reactive protein is a robust predictor of metastasis and mortality after nephrectomy for localized renal cell carcinoma. Clinicians should consider absolute preoperative C-reactive protein to identify high risk patients for closer surveillance or additional therapy. In addition, predictive algorithms and models of metastasis should consider incorporating C-reactive protein as a continuous variable to maximize predictive ability.


Assuntos
Biomarcadores Tumorais/sangue , Proteína C-Reativa/análise , Carcinoma de Células Renais/sangue , Carcinoma de Células Renais/cirurgia , Neoplasias Renais/sangue , Neoplasias Renais/cirurgia , Nefrectomia , Carcinoma de Células Renais/mortalidade , Carcinoma de Células Renais/secundário , Feminino , Humanos , Neoplasias Renais/mortalidade , Neoplasias Renais/patologia , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Valor Preditivo dos Testes , Período Pré-Operatório , Estudos Prospectivos , Taxa de Sobrevida , Fatores de Tempo
4.
Science ; 169(3948): 855-8, 1970 Aug 28.
Artigo em Inglês | MEDLINE | ID: mdl-17750053

RESUMO

The spectral reflectivity (0.30 to 2.50 microns) of several lunar areas was measured with ground-based telescopes. A narrow absorption band centered at 0.95 micron was revealed for the first time. No other absorption bands appear in the spectrum. The reflectivity continues to rise at longer wavelengths throughout the spectral region studied. A comparison of the telescope measurements of an area 15 kilometers in diameter that includes Tranquillity Base with laboratory measurements of Apollo 11 soil samples reveals remarkable agreement, an indication that properties determined for fairly large lunar areas are relevant to local conditions. The spectra are interpretable in terms of surface mineralogy. The absorption band varies in both depth and shape and the overall slope of the curve changes with lunar area, an indication of differences in the composition and opacity of surface material. However, the lack of variety in the band position suggests there are no major differences (say, from mostly pyroxenes to mostly olivines) in the mineralogy at those sites studied.

5.
Science ; 253(5027): 1516-8, 1991 Sep 27.
Artigo em Inglês | MEDLINE | ID: mdl-17784091

RESUMO

The Galileo spacecraft passed Venus on its way to Jupiter on 10 February 1990, less than 4 months after launch from Earth aboard the shuttle Atlantis. Because Galileo's instruments were selected for broad-based planetary exploration, the spacecraft was able to obtain a wide range of measurements during the Venus encounter. Together with ground-based observations conducted during the encounter, these observations have yielded more accurate information about the planet's plasma environment, cloud patterns, and the possible existence of lightning.

6.
Science ; 186(4167): 922-5, 1974 Dec 06.
Artigo em Inglês | MEDLINE | ID: mdl-17730914

RESUMO

A model is suggested for Io's surface composition involving evaporite salt deposits, rich in sodium and sulfur. According to this model, these deposits were produced as a result of the migration of salt-saturated aqueous solutions to Io's surface from a warm or hot interior followed by loss of the water to space. This model satisfies cosmochemical constraints based on Io's initial composition, current density, and thermal history. Salt-rich assemblages are easily derivable from the leaching of carbonaceous chondritic material; the chemical and optical properties of such deposits, after modification by irradiation, can be used to explain Io's overall albedo and spectral reflectance, its dark reddish poles, and the observed sodium emission as well as or better than other currently suggested materials.

7.
Science ; 168(3938): 1445-7, 1970 Jun 19.
Artigo em Inglês | MEDLINE | ID: mdl-17731590

RESUMO

The spectral reflectivity (0.30 to 1.10 microns) of several asteroids has been measured for the first time. The reflection spectrum for Vesta contains a strong absorption band centered near 0.9 micron and a weaker absorption feature between 0.5 and 0.6 micron. The reflectivity decreases strongly in the ultraviolet. The reflection spectrum for the asteroid Pallas and probably for Ceres does not contain the 0.9-micron band. Vesta shows the strongest and best-defined absorption bands yet seen in the reflection spectrum for the solid surface of an object in the solar system. The strong 0.9-micron band arises from electronic absorptions in ferrous iron on the M2 site of a magnesian pyroxene. Comparison with laboratory measurements on meteorites and Apollo 11 samples indicates that the surface of Vesta has a composition very similar to that of certain basaltic achondrites.

8.
Science ; 251(5000): 1465-7, 1991 Mar 22.
Artigo em Inglês | MEDLINE | ID: mdl-17779439

RESUMO

Internal heat flow from radioactive decay in Triton's interior along with absorbed thermal energy from Neptune total 5 to 20 percent of the insolation absorbed by Triton, thus comprising a significant fraction of Triton's surface energy balance. These additional energy inputs can raise Triton's surface temperature between approximately 0.5 and 1.5 K above that possible with absorbed sunlight alone, resulting in an increase of about a factor of approximately 1.5 to 2.5 in Triton's basal atmospheric pressure. If Triton's internal heat flow is concentrated in some areas, as is likely, local effects such as enhanced sublimation with subsequent modification of albedo could be quite large. Furthermore, indications of recent global albedo change on Triton suggest that Triton's surface temperature and pressure may not now be in steady state, further suggesting that atmospheric pressure on Triton was as much as ten times higher in the recent past.

9.
Science ; 199(4328): 531-3, 1978 Feb 03.
Artigo em Inglês | MEDLINE | ID: mdl-17750020

RESUMO

The first direct images of Io's sodium cloud are reported and analyzed. The observed cloud extends for more than 10(5) kilometers along Io's orbit and is a somewhat "banana-shaped" partial toroid. More sodium atoms precede Io than follow it. A model based on the escape of sodium from a specific localized area on Io provides a reasonable fit to the observed intensity distribution whereas isotropic escape does not.

10.
Science ; 250(4979): 431-5, 1990 Oct 19.
Artigo em Inglês | MEDLINE | ID: mdl-17793021

RESUMO

Four geyser-like plumes were discovered near Triton's south pole in areas now in permanent sunlight. Because Triton's southern hemisphere is nearing a maximum summer solstice, insolation as a driver or a trigger for Triton's geyser-like plumes is an attractive hypothesis. Trapping of solar radiation in a translucent, low-conductivity surface layer (in a solid-state greenhouse), which is subsequently released in the form of latent heat of sublimation, could provide the required energy. Both the classical solid-state greenhouse consisting of exponentially absorbed insolation in a gray, translucent layer of solid nitrogen, and the "super" greenhouse consisting of a relatively transparent solid-nitrogen layer over an opaque, absorbing layer are plausible candidates. Geothermal heat may also play a part if assisted by the added energy input of seasonal cycles of insolation.

11.
Science ; 242(4883): 1280-3, 1988 Dec 02.
Artigo em Inglês | MEDLINE | ID: mdl-17817074

RESUMO

Infrared observations of Io during the 1986 apparition of Jupiter indicate that a large eruptive event occurred on the leading side of Io on 7 August 1986, Universal Time. Measurements made at 4.8, 8.7, and 20 micrometers suggest that the source of the event was about 15 kilometers in radius with a model temperature of approximately 900 Kelvin. Together with previously reported events, these measurements indicate that high-temperature volcanic activity on the leading side of Io may be more frequent than previously thought. The inferred temperature is significantly above the boiling point of sulfur in a vacuum(715 Kelvin) and thus constitutes strong evidence for active silicate volcanism on the surface of Io.

12.
Science ; 211(4489): 1419-22, 1981 Mar 27.
Artigo em Inglês | MEDLINE | ID: mdl-17731183

RESUMO

A quadruple long exposure of Io in eclipse exhibits faint auroral emission from the eruptive plumes. No luminous spots in the vents, predicted by Gold, were observed. Heat from the interior of Io appears to be the predominant source of energy in the plumes.

13.
Science ; 285(5429): 870-4, 1999 Aug 06.
Artigo em Inglês | MEDLINE | ID: mdl-10436151

RESUMO

The Galileo spacecraft has detected diffuse optical emissions from Io in high-resolution images acquired while the satellite was eclipsed by Jupiter. Three distinct components make up Io's visible emissions. Bright blue glows of more than 300 kilorayleighs emanate from volcanic plumes, probably due to electron impact on molecular sulfur dioxide. Weaker red emissions, possibly due to atomic oxygen, are seen along the limbs, brighter on the pole closest to the plasma torus. A faint green glow appears concentrated on the night side of Io, possibly produced by atomic sodium. Io's disk-averaged emission diminishes with time after entering eclipse, whereas the localized blue glows brighten instead.


Assuntos
Meio Ambiente Extraterreno , Júpiter , Oxigênio , Dióxido de Enxofre , Atmosfera , Sódio
14.
Science ; 226(4671): 134-7, 1984 Oct 12.
Artigo em Inglês | MEDLINE | ID: mdl-17814324

RESUMO

We report the first results of a program to determine the longitudinal distribution of volcanic activity on Jupiter's satellite Io. Infrared measurements at 8.7, 10, and 20 micrometers have been taken at a variety of orbital longitudes: strong variation in the 8.7- and 10-micrometer flux with longitude demonstrates that infrared emission arising from volcanic hotspots on Io is strongly concentrated in a few locations. Analysis of these data suggests that the active volcanic regions observed by the Voyager experimenters are still active, particularly the region around the feature known as Loki. Another source of flux, although of somewhat smaller magnitude, is indicated on the opposite hemisphere. If these sources are the only major volcanic centers on Io, then current global heat flow estimates must be revised downward. However, heat flow from as yet unobserved longitudes, hotspots at high latitudes, and conducted heat flow must still be measured.

15.
Science ; 250(4979): 419-21, 1990 Oct 19.
Artigo em Inglês | MEDLINE | ID: mdl-17793017

RESUMO

Hapke's photometric model has been combined with a plane-parallel thin atmospheric haze model to describe Voyager whole-disk observations of Triton, in the violet (0.41 microm), blue (0.48 microm), and green (0.56 microm) wavelength bands, in order to obtain estimates of Triton's geometric albedo, phase integral, and Bond albedo. Phase angle coverage in these filters ranging from approximately 12 degrees to 159 degrees was obtained by combining narrow- and wide-angle camera images. An upturn in the data at the highest phase angles observed can be explained by including scattering in a thin atmospheric haze layer with optical depths systematically decreasing with wavelength from approximately 0.06 in the violet to 0.03 for the green filter data. The geometric albedo, phase integral, and spherical albedo of Triton in each filter corresponding to our best fit Hapke parameters yield an estimated Bond albedo of 0.82 +/- 0.05. If the 14-microbar N(2) atmosphere detected by Voyager is in vapor equilibrium with the surface (therefore implying a surface temperature of 37.5 K), our Bond albedo implies a surface emissivity of 0.59 +/- 0.16.

16.
Science ; 182(4107): 53-5, 1973 Oct 05.
Artigo em Inglês | MEDLINE | ID: mdl-17829812

RESUMO

On 7 June 1972 the third , Jovian satellite Ganymede occulted the eighth-magnitude star SAO 186800. Successful photoelectric observations obtained at Lembang, Java (Indonesia), and Kavalur, India, show nonabrupt immersions and emersions, indicating the presence of an atmosphere whose surface pressure is greater than about 10(-3) millibar. By fitting the two occultation durations as chords to a model disk, the diameter is found to be 5270 (+30, - approximately 200) kilometers, the major error contribution arising from the uncertain atmospheric thickness below the occultation layer. The derived mean density is 2.0 (-0.03, + approximately 0.2) grams per cubic centimeter.

17.
Science ; 250(4979): 410-5, 1990 Oct 19.
Artigo em Inglês | MEDLINE | ID: mdl-17793016

RESUMO

At least four active geyser-like eruptions were discovered in Voyager 2 images of Triton, Neptune's large satellite. The two best documented eruptions occur as columns of dark material rising to an altitude of about 8 kilometers where dark clouds of material are left suspended to drift downwind over 100 kilometers. The radii of the rising columns appear to be in the range of several tens of meters to a kilometer. One model for the mechanism to drive the plumes involves heating of nitrogen ice in a subsurface greenhouse environment; nitrogen gas pressurized by the solar heating explosively vents to the surface carrying clouds of ice and dark partides into the atmosphere. A temperature increase of less than 4 kelvins above the ambient surface value of 38 +/- 3 kelvins is more than adequate to drive the plumes to an 8-kilometer altitude. The mass flux in the trailing clouds is estimated to consist of up to 10 kilograms of fine dark particles per second or twice as much nitrogen ice and perhaps several hundred or more kilograms of nitrogen gas per second. Each eruption may last a year or more, during which on the order of a tenth of a cubic kilometer of ice is sublimed.

18.
Science ; 278(5336): 271-5, 1997 Oct 10.
Artigo em Inglês | MEDLINE | ID: mdl-9323203

RESUMO

Five absorption features are reported at wavelengths of 3.4, 3.88, 4. 05, 4.25, and 4.57 micrometers in the surface materials of the Galilean satellites Callisto and Ganymede from analysis of reflectance spectra returned by the Galileo mission near-infrared mapping spectrometer. Candidate materials include CO2, organic materials (such as tholins containing C(triple bond)N and C-H), SO2, and compounds containing an SH-functional group; CO2, SO2, and perhaps cyanogen [(CN)2] may be present within the surface material itself as collections of a few molecules each. The spectra indicate that the primary surface constituents are water ice and hydrated minerals.


Assuntos
Dióxido de Carbono/análise , Júpiter , Nitrilas/análise , Enxofre/análise , Hidrocarbonetos/análise , Gelo , Análise Espectral , Dióxido de Enxofre/análise , Água
19.
Science ; 280(5367): 1242-5, 1998 May 22.
Artigo em Inglês | MEDLINE | ID: mdl-9596573

RESUMO

Reflectance spectra in the 1- to 2.5-micrometer wavelength region of the surface of Europa obtained by Galileo's Near Infrared Mapping Spectrometer exhibit distorted water absorption bands that indicate the presence of hydrated minerals. The laboratory spectra of hydrated salt minerals such as magnesium sulfates and sodium carbonates and mixtures of these minerals provide a close match to the Europa spectra. The distorted bands are only observed in the optically darker areas of Europa, including the lineaments, and may represent evaporite deposits formed by water, rich in dissolved salts, reaching the surface from a water-rich layer underlying an ice crust.


Assuntos
Júpiter , Sais , Água , Carbonatos , Evolução Planetária , Gelo , Sulfato de Magnésio , Oceanos e Mares , Espectrofotometria Infravermelho , Temperatura
20.
Science ; 281(5373): 87-90, 1998 Jul 03.
Artigo em Inglês | MEDLINE | ID: mdl-9651251

RESUMO

Infrared wavelength observations of Io by the Galileo spacecraft show that at least 12 different vents are erupting lavas that are probably hotter than the highest temperature basaltic eruptions on Earth today. In at least one case, the eruption near Pillan Patera, two independent instruments on Galileo show that the lava temperature must have exceeded 1700 kelvin and may have reached 2000 kelvin. The most likely explanation is that these lavas are ultramafic (magnesium-rich) silicates, and this idea is supported by the tentative identification of magnesium-rich orthopyroxene in lava flows associated with these high-temperature hot spots.


Assuntos
Meio Ambiente Extraterreno , Júpiter , Silicatos , Temperatura Alta , Minerais , Espectrofotometria Infravermelho , Erupções Vulcânicas
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