Detalhe da pesquisa
1.
Multidomain Control Over TEC Kinase Activation State Tunes the T Cell Response.
Annu Rev Immunol
; 36: 549-578, 2018 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29677469
2.
Screening and Characterization of Allosteric Small Molecules Targeting Bruton's Tyrosine Kinase.
Biochemistry
; 63(1): 94-106, 2024 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38091504
3.
Lipid-targeting pleckstrin homology domain turns its autoinhibitory face toward the TEC kinases.
Proc Natl Acad Sci U S A
; 116(43): 21539-21544, 2019 10 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-31591208
4.
An Autoinhibitory Role for the Pleckstrin Homology Domain of Interleukin-2-Inducible Tyrosine Kinase and Its Interplay with Canonical Phospholipid Recognition.
Biochemistry
; 56(23): 2938-2949, 2017 06 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28516764
5.
Dynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases.
PLoS Comput Biol
; 12(3): e1004826, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-27010561
6.
Conformational snapshots of Tec kinases during signaling.
Immunol Rev
; 228(1): 74-92, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19290922
7.
Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia.
bioRxiv
; 2023 Dec 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-38187560
8.
Disrupting the intermolecular self-association of Itk enhances T cell signaling.
J Immunol
; 184(8): 4228-35, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20237289
9.
Structure of the interleukin-2 tyrosine kinase Src homology 2 domain; comparison between X-ray and NMR-derived structures.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 68(Pt 2): 145-53, 2012 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22297986
10.
Itk tyrosine kinase substrate docking is mediated by a nonclassical SH2 domain surface of PLCgamma1.
Proc Natl Acad Sci U S A
; 106(50): 21143-8, 2009 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19955438
11.
Conformational switches that control the TEC kinase - PLCγ signaling axis.
J Struct Biol X
; 6: 100061, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35128378
12.
The Conformational State of the BTK Substrate PLCγ Contributes to Ibrutinib Resistance.
J Mol Biol
; 434(5): 167422, 2022 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34954235
13.
Controlling the activity of the Tec kinase Itk by mutation of the phenylalanine gatekeeper residue.
Biochemistry
; 50(2): 221-9, 2011 Jan 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-21138328
14.
Purification, crystallization and preliminary crystallographic analysis of the SH2 domain of IL-2-inducible T-cell kinase.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 67(Pt 2): 269-73, 2011 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21301103
15.
Reining in BTK: Interdomain Interactions and Their Importance in the Regulatory Control of BTK.
Front Cell Dev Biol
; 9: 655489, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34249912
16.
Differential impact of BTK active site inhibitors on the conformational state of full-length BTK.
Elife
; 92020 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-33226337
17.
Mechanism and functional significance of Itk autophosphorylation.
J Mol Biol
; 373(5): 1281-92, 2007 Nov 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-17897671
18.
Bacterial expression and purification of interleukin-2 tyrosine kinase: single step separation of the chaperonin impurity.
Protein Expr Purif
; 60(2): 194-7, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18495488
19.
Achieving a Graded Immune Response: BTK Adopts a Range of Active/Inactive Conformations Dictated by Multiple Interdomain Contacts.
Structure
; 25(10): 1481-1494.e4, 2017 10 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28867612
20.
Dynamics of the Tec-family tyrosine kinase SH3 domains.
Protein Sci
; 25(4): 852-64, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26808198