RESUMO
Anonymous technology is an effective way for protecting users' privacy. Anonymity in sensor networks is to prevent the unauthorized third party from revealing the identities of the communication parties. While, in unstable wireless sensor networks, frequent topology changes often lead to route-failure in anonymous communication. To deal with the problems of anonymous route-failure in unstable sensor networks, in this paper we propose a fully anonymous routing protocol with self-healing capability in unstable sensor networks by constructing a new key agreement scheme and proposing an anonymous identity scheme. The proposed protocol maintains full anonymity of sensor nodes with the self-healing capability of anonymous routes. The results from the performance analysis show that the proposed self-healing anonymity-focused protocol achieves full anonymity of source nodes, destination nodes, and communication association.
RESUMO
AIM: To explore the possible relationship between expression of PPAR(pevoxisome prodiferator adivated receptor) beta and clinical pathological features of epithelial ovarian carcinoma (EOC). METHODS: PPARbeta expressions in normal ovaries (n=10), ovarian bordline tumors (n=10), and ovarian serous cystadenocarcinomas (n=46) were investigated by immunohistochemistry and RT-PCR. RESULTS: PPARbeta protein was expressed in normal ovaries and ovarian cancer. PPARbeta protein was found in cytoplasm of tumor cell. PPARbeta expression was 20% revealed in normal ovaries, 50% in bordline tumors 89.1% in serous cystadenocarcinomas(P<0.05), significantly higher than that in bordline tumors (P<0.05). PPARbeta expression was positively correlated with tumor stage, histological grade and lymphonode metastasis (P<0.05). CONCLUSION: High expression of PPARbeta may be related with the differentiation and metastasis of epithelial ovarian carcinoma.
Assuntos
Cistadenocarcinoma Seroso/genética , Cistadenocarcinoma Seroso/metabolismo , Neoplasias Ovarianas/genética , Neoplasias Ovarianas/metabolismo , PPAR beta/genética , PPAR beta/metabolismo , Adulto , Idoso , Feminino , Humanos , Imuno-Histoquímica , Pessoa de Meia-Idade , Reação em Cadeia da Polimerase Via Transcriptase ReversaRESUMO
AIM: The differential expression of USP2, USP14 and UBE4A between ovarian serous cystadenocarcinoma and adjacent normal tissues was investigated. METHODS: Restriction fragment differential display polymerase chain reaction (RFDD-PCR), semi-quantitative RT-PCR and immunohistochemical staining were applied to analyze the differentially expressed genes and proteins of ubiquitin specific proteases (USPs), USP2 and USP14, and ubiquitin factor E4A (UBE4A) between ovarian serous cystadenocarcinoma and adjacent normal tissues obtained from 40 patients aged from 29 to 72 years old, collected in 2005 year at excision of surgical operation with ovarian serous cystadenocarcinoma. RESULTS: USP2, USP14 and UBE4A were over-expressed (>3 folds) in ovarian serous cystadenocarcinoma tissues compared to normal tissues. CONCLUSION: The results suggest that the activity of ubiquitin-proteasome system is obviously enhanced in ovarian cancer.