Detalhe da pesquisa
1.
Synthesis and biological evaluation of pyridine-linked indanone derivatives: Potential agents for inflammatory bowel disease.
Bioorg Med Chem Lett
; 28(14): 2436-2441, 2018 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29910080
2.
Synthesis and SAR study of new hydroxy and chloro-substituted 2,4-diphenyl 5H-chromeno[4,3-b]pyridines as selective topoisomerase IIα-targeting anticancer agents.
Bioorg Med Chem
; 26(8): 1909-1919, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29510948
3.
Synthesis and evaluation of an orally available "Y"-shaped biaryl peroxisome proliferator-activated receptor δ agonist.
Bioorg Med Chem
; 26(15): 4382-4389, 2018 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30054191
4.
2-Chlorophenyl-substituted benzofuro[3,2-b]pyridines with enhanced topoisomerase inhibitory activity: The role of the chlorine substituent.
Bioorg Med Chem Lett
; 27(15): 3279-3283, 2017 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28633898
5.
Effect of chlorine substituent on cytotoxic activities: Design and synthesis of systematically modified 2,4-diphenyl-5H-indeno[1,2-b]pyridines.
Bioorg Med Chem Lett
; 26(7): 1726-31, 2016 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26927425
6.
Synthesis and biological evaluation of 2-phenol-4-chlorophenyl-6-aryl pyridines as topoisomerase II inhibitors and cytotoxic agents.
Bioorg Chem
; 66: 145-59, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27174797
7.
Design and synthesis of novel 2,4-diaryl-5H-indeno[1,2-b]pyridine derivatives, and their evaluation of topoisomerase inhibitory activity and cytotoxicity.
Bioorg Med Chem
; 23(1): 160-73, 2015 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25481396
8.
Topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of dihydroxylated 2,6-diphenyl-4-aryl pyridines.
Bioorg Med Chem
; 23(13): 3638-54, 2015 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25936262
9.
Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of 2-phenyl- or hydroxylated 2-phenyl-4-aryl-5H-indeno[1,2-b]pyridines.
Bioorg Med Chem
; 23(13): 3499-512, 2015 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26022080
10.
Design and synthesis of conformationally constrained hydroxylated 4-phenyl-2-aryl chromenopyridines as novel and selective topoisomerase II-targeted antiproliferative agents.
Bioorg Med Chem
; 23(19): 6454-66, 2015 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26361737
11.
Modified 2,4-diaryl-5H-indeno[1,2-b]pyridines with hydroxyl and chlorine moiety: Synthesis, anticancer activity, and structure-activity relationship study.
Bioorg Chem
; 62: 30-40, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26218799
12.
Antitrypanosomal Chloronitrobenzamides.
J Med Chem
; 67(5): 3437-3447, 2024 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38363074
13.
Optimization of Orally Bioavailable Antileishmanial 2,4,5-Trisubstituted Benzamides.
J Med Chem
; 66(11): 7374-7386, 2023 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37216489
14.
Identification of new halogen-containing 2,4-diphenyl indenopyridin-5-one derivative as a boosting agent for the anticancer responses of clinically available topoisomerase inhibitors.
Eur J Med Chem
; 227: 113916, 2022 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34678573
15.
Discovery of a 2,4-diphenyl-5,6-dihydrobenzo(h)quinolin-8-amine derivative as a novel DNA intercalating topoisomerase IIα poison.
Eur J Med Chem
; 226: 113860, 2021 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34597897
16.
Targeting the Nuclear Receptor-Binding SET Domain Family of Histone Lysine Methyltransferases for Cancer Therapy: Recent Progress and Perspectives.
J Med Chem
; 64(20): 14913-14929, 2021 10 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34488340
17.
Targeting Peroxisome Proliferator-Activated Receptor Delta (PPARδ): A Medicinal Chemistry Perspective.
J Med Chem
; 63(18): 10109-10134, 2020 09 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32539376
18.
An orally available inverse agonist of estrogen-related receptor gamma showed expanded efficacy for the radioiodine therapy of poorly differentiated thyroid cancer.
Eur J Med Chem
; 205: 112501, 2020 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32758860
19.
Discovery and Biological Evaluations of Halogenated 2,4-Diphenyl Indeno[1,2-b]pyridinol Derivatives as Potent Topoisomerase IIα-Targeted Chemotherapeutic Agents for Breast Cancer.
J Med Chem
; 62(17): 8194-8234, 2019 09 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31398033
20.
Ameliorating effect of TI-1-162, a hydroxyindenone derivative, against TNBS-induced rat colitis is mediated through suppression of RIP/ASK-1/MAPK signaling.
Eur J Pharmacol
; 827: 94-102, 2018 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29555502