1.
Nat Chem Biol
; 12(1): 6-8, 2016 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26551396
RESUMO
The carbon skeleton of ecologically and pharmacologically important iridoid monoterpenes is formed in a reductive cyclization reaction unrelated to canonical terpene cyclization. Here we report the crystal structure of the recently discovered iridoid cyclase (from Catharanthus roseus) bound to a mechanism-inspired inhibitor that illuminates substrate binding and catalytic function of the enzyme. Key features that distinguish iridoid synthase from its close homolog progesterone 5ß-reductase are highlighted.