Detalhe da pesquisa
1.
Novel, potent, orally bioavailable and selective mycobacterial ATP synthase inhibitors that demonstrated activity against both replicating and non-replicating M. tuberculosis.
Bioorg Med Chem
; 23(4): 742-52, 2015 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25614114
2.
Design, synthesis and biological evaluation of bicyclic iminosugar hybrids: conformational constraint as an effective tool for tailoring the selectivity of α-glucosidase inhibitors.
Org Biomol Chem
; 12(35): 6855-68, 2014 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-25050482
3.
Synthesis and biological evaluation of trans 6-methoxy-1,1-dimethyl-2-phenyl-3-aryl-2,3-dihydro-1H-inden-4-yloxyalkylamine derivatives against drug susceptible, non-replicating M. tuberculosis H37Rv and clinical multidrug resistant strains.
Bioorg Med Chem Lett
; 23(8): 2404-7, 2013 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23474387
4.
In vivo activity of thiophene-containing trisubstituted methanes against acute and persistent infection of non-tubercular Mycobacterium fortuitum in a murine infection model.
J Antimicrob Chemother
; 67(5): 1188-97, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22311937
5.
Identification and characterisation of small-molecule inhibitors of Rv3097c-encoded lipase (LipY) of Mycobacterium tuberculosis that selectively inhibit growth of bacilli in hypoxia.
Int J Antimicrob Agents
; 42(1): 27-35, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23684389