Detalhe da pesquisa
1.
Safety, pharmacokinetics, and pharmacodynamics of Gln-1062, a prodrug of galantamine.
Alzheimers Dement (N Y)
; 6(1): e12093, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33083515
2.
Progranulin is expressed within motor neurons and promotes neuronal cell survival.
BMC Neurosci
; 10: 130, 2009 Oct 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-19860916
3.
Progranulin gene delivery reduces plaque burden and synaptic atrophy in a mouse model of Alzheimer's disease.
PLoS One
; 12(8): e0182896, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28837568
4.
Neurotrophic effects of progranulin in vivo in reversing motor neuron defects caused by over or under expression of TDP-43 or FUS.
PLoS One
; 12(3): e0174784, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28358904
5.
First in human study with a prodrug of galantamine: Improved benefit-risk ratio?
Alzheimers Dement (N Y)
; 2(1): 13-22, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-29067291
6.
The Progressive BSSG Rat Model of Parkinson's: Recapitulating Multiple Key Features of the Human Disease.
PLoS One
; 10(10): e0139694, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26439489
7.
Progranulin gene delivery protects dopaminergic neurons in a mouse model of Parkinson's disease.
PLoS One
; 9(5): e97032, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24804730
8.
Panax ginseng is neuroprotective in a novel progressive model of Parkinson's disease.
Exp Gerontol
; 50: 95-105, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24316034
9.
Progranulin modulates zebrafish motoneuron development in vivo and rescues truncation defects associated with knockdown of Survival motor neuron 1.
Mol Neurodegener
; 5: 41, 2010 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-20946666
10.
Overexpression of Notch1 ectodomain in myeloid cells induces vascular malformations through a paracrine pathway.
Am J Pathol
; 170(1): 399-415, 2007 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17200211
11.
Structurally distinct ligand-binding or ligand-independent Notch1 mutants are leukemogenic but affect thymocyte development, apoptosis, and metastasis differently.
J Immunol
; 177(4): 2153-66, 2006 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16887975
12.
Expression of constitutively active Notch1 in male genital tracts results in ectopic growth and blockage of efferent ducts, epididymal hyperplasia and sterility.
Dev Biol
; 300(2): 497-511, 2006 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17046738
13.
The Nef-mediated AIDS-like disease of CD4C/human immunodeficiency virus transgenic mice is associated with increased Fas/FasL expression on T cells and T-cell death but is not prevented in Fas-, FasL-, tumor necrosis factor receptor 1-, or interleukin-1beta-converting enzyme-deficient or Bcl2-expressing transgenic mice.
J Virol
; 79(10): 6377-91, 2005 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15858021
14.
Oligodendrocyte-specific expression of human immunodeficiency virus type 1 Nef in transgenic mice leads to vacuolar myelopathy and alters oligodendrocyte phenotype in vitro.
J Virol
; 77(21): 11745-53, 2003 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-14557659
15.
Expression of simian immunodeficiency virus nef in immune cells of transgenic mice leads to a severe AIDS-like disease.
J Virol
; 76(8): 3981-95, 2002 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-11907238
16.
In vivo mutational analysis of the N-terminal region of HIV-1 Nef reveals critical motifs for the development of an AIDS-like disease in CD4C/HIV transgenic mice.
Virology
; 327(2): 273-86, 2004 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15351215
17.
The AIDS-like disease of CD4C/human immunodeficiency virus transgenic mice is associated with accumulation of immature CD11bHi dendritic cells.
J Virol
; 77(21): 11733-44, 2003 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-14557658
18.
Cardiac disease in transgenic mice expressing human immunodeficiency virus-1 nef in cells of the immune system.
Am J Pathol
; 161(1): 321-35, 2002 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-12107117
19.
Protection against murine leukemia virus-induced spongiform myeloencephalopathy in mice overexpressing Bcl-2 but not in mice deficient for interleukin-6, inducible nitric oxide synthetase, ICE, Fas, Fas ligand, or TNF-R1 genes.
J Virol
; 77(24): 13161-70, 2003 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-14645573
20.
Mucosal candidiasis in transgenic mice expressing human immunodeficiency virus type 1.
J Infect Dis
; 185(8): 1103-14, 2002 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-11930320