Detalhe da pesquisa
1.
Comparison of Toxicities among Different Bumped Kinase Inhibitor Analogs for Treatment of Cryptosporidiosis.
Antimicrob Agents Chemother
; 67(4): e0142522, 2023 04 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36920244
2.
A specific inhibitor of PfCDPK4 blocks malaria transmission: chemical-genetic validation.
J Infect Dis
; 209(2): 275-84, 2014 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24123773
3.
Discovery of pyrido[2,3-d]pyrimidine-based inhibitors of HCV NS5A.
Bioorg Med Chem Lett
; 23(12): 3627-30, 2013 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23642966
4.
A Phase-I pharmacokinetic, safety and food-effect study on flubentylosin, a novel analog of Tylosin-A having potent anti-Wolbachia and antifilarial activity.
PLoS Negl Trop Dis
; 17(7): e0011392, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37428804
5.
Novel hepatitis C virus replicon inhibitors: synthesis and structure-activity relationships of fused pyrimidine derivatives.
Bioorg Med Chem Lett
; 22(6): 2212-5, 2012 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22342631
6.
Hepatitis C NS5B polymerase inhibitors: functional equivalents for the benzothiadiazine moiety.
Bioorg Med Chem Lett
; 21(6): 1876-9, 2011 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21316235
7.
Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy.
Proc Natl Acad Sci U S A
; 105(10): 3879-84, 2008 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-18332425
8.
Pyrrolopyrimidine Bumped Kinase Inhibitors for the Treatment of Cryptosporidiosis.
ACS Infect Dis
; 7(5): 1200-1207, 2021 05 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33565854
9.
Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Mycobacterium tuberculosis Growth.
ACS Omega
; 6(3): 2284-2311, 2021 Jan 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-33521468
10.
Prevalence, mutation patterns, and effects on protease inhibitor susceptibility of the L76V mutation in HIV-1 protease.
Antimicrob Agents Chemother
; 54(11): 4903-6, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20805393
11.
Non-peptide entry inhibitors of HIV-1 that target the gp41 coiled coil pocket.
Bioorg Med Chem Lett
; 20(2): 612-7, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20004576
12.
Identification of proteasome gene regulation in a rat model for HIV protease inhibitor-induced hyperlipidemia.
Arch Toxicol
; 84(4): 263-70, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20213465
13.
Assembling Pharma Resources to Tackle Diseases of Underserved Populations.
ACS Med Chem Lett
; 11(6): 1094-1100, 2020 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32550987
14.
Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned.
Int J Parasitol
; 50(5): 413-422, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32224121
15.
ART suppresses plasma HIV-1 RNA to a stable set point predicted by pretherapy viremia.
PLoS Pathog
; 3(4): e46, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17411338
16.
Synthesis and evaluation of inhibitors of cytochrome P450 3A (CYP3A) for pharmacokinetic enhancement of drugs.
Bioorg Med Chem Lett
; 19(18): 5444-8, 2009 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19679477
17.
In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae.
PLoS Negl Trop Dis
; 13(8): e0007636, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31381563
18.
Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity.
PLoS Negl Trop Dis
; 13(2): e0007159, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30818326
19.
Preclinical development of an oral anti-Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis.
Sci Transl Med
; 11(483)2019 03 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30867321
20.
A human immunodeficiency virus protease inhibitor is a novel functional inhibitor of human pregnane X receptor.
Drug Metab Dispos
; 36(3): 500-7, 2008 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-18096673