Detalhe da pesquisa
1.
Novel pharmacological chaperones that correct phenylketonuria in mice.
Hum Mol Genet
; 21(8): 1877-87, 2012 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22246293
2.
The interplay between genotype, metabolic state and cofactor treatment governs phenylalanine hydroxylase function and drug response.
Hum Mol Genet
; 20(13): 2628-41, 2011 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21527427
3.
Efficient stabilization of therapeutic hepatitis B vaccine components by amino-acid formulation maintains its potential to break immune tolerance.
JHEP Rep
; 5(2): 100603, 2023 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-36714793
4.
Pahenu1 is a mouse model for tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency and promotes analysis of the pharmacological chaperone mechanism in vivo.
Hum Mol Genet
; 19(10): 2039-49, 2010 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20179079
5.
Activation of phenylalanine hydroxylase induces positive cooperativity toward the natural cofactor.
J Biol Chem
; 285(40): 30686-97, 2010 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20667834
6.
Protein misfolding is the molecular mechanism underlying MCADD identified in newborn screening.
Hum Mol Genet
; 18(9): 1612-23, 2009 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19224950
7.
Loss of function in phenylketonuria is caused by impaired molecular motions and conformational instability.
Am J Hum Genet
; 83(1): 5-17, 2008 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-18538294
8.
Algorithm-Based Liquid Formulation Development Including a DoE Concept Predicts Long-Term Viral Vector Stability.
J Pharm Sci
; 109(1): 818-829, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31689430
9.
Amino Acid-Based Advanced Liquid Formulation Development for Highly Concentrated Therapeutic Antibodies Balances Physical and Chemical Stability and Low Viscosity.
Biotechnol J
; 13(7): e1700523, 2018 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-29663661
10.
Ligand binding properties of the N-terminal domain of riboflavin synthase from Escherichia coli.
J Biochem Mol Biol
; 40(2): 239-46, 2007 Mar 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-17394775
11.
Crystal structure of Schizosaccharomyces pombe riboflavin kinase reveals a novel ATP and riboflavin-binding fold.
J Mol Biol
; 326(5): 1463-73, 2003 Mar 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-12595258
12.
Riboflavin synthase of Schizosaccharomyces pombe. Protein dynamics revealed by 19F NMR protein perturbation experiments.
BMC Biochem
; 4: 18, 2003 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-14690539
13.
Induction of protective immunity against H1N1 influenza A(H1N1)pdm09 with spray-dried and electron-beam sterilised vaccines in non-human primates.
Vaccine
; 32(19): 2231-40, 2014 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-24631078
14.
The domain-specific and temperature-dependent protein misfolding phenotype of variant medium-chain acyl-CoA dehydrogenase.
PLoS One
; 9(4): e93852, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24718418
15.
13C-, 15N- and 31P-NMR studies of oxidized and reduced low molecular mass thioredoxin reductase and some mutant proteins.
Eur J Biochem
; 271(8): 1437-52, 2004 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-15066170
16.
Investigation of the binding of epimer A of the covalent hydrate of 6,7-bis(trifluoromethyl)-8-D-ribityllumazine to a recombinant F22W Bacillus subtilis lumazine synthase mutant by (15)N[(19)F] REDOR NMR.
J Org Chem
; 67(7): 2087-92, 2002 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-11925213