Wavelet-based 3D reconstruction of microcalcification clusters from two mammographic views: new evidence that fractal tumors are malignant and Euclidean tumors are benign.

The 2D Wavelet-Transform Modulus Maxima (WTMM) method was used to detect microcalcifications (MC) in human breast tissue seen in mammograms and to characterize the fractal geometry of benign and malignant MC clusters. This was done in the context of a preliminary analysis of a small dataset, via a novel way to partition the wavelet-transform space-scale skeleton. For the first time, the estimated 3D fractal structure of a breast lesion was inferred by pairing the information from two separate 2D projected mammographic views of the same breast, i.e. the cranial-caudal (CC) and mediolateral-oblique (MLO) views. As a novelty, we define the "CC-MLO fractal dimension plot", where a "fractal zone" and "Euclidean zones" (non-fractal) are defined. 118 images (59 cases, 25 malignant and 34 benign) obtained from a digital databank of mammograms with known radiologist diagnostics were analyzed to determine which cases would be plotted in the fractal zone and which cases would fall in the Euclidean zones. 92% of malignant breast lesions studied (23 out of 25 cases) were in the fractal zone while 88% of the benign lesions were in the Euclidean zones (30 out of 34 cases). Furthermore, a Bayesian statistical analysis shows that, with 95% credibility, the probability that fractal breast lesions are malignant is between 74% and 98%. Alternatively, with 95% credibility, the probability that Euclidean breast lesions are benign is between 76% and 96%. These results support the notion that the fractal structure of malignant tumors is more likely to be associated with an invasive behavior into the surrounding tissue compared to the less invasive, Euclidean structure of benign tumors. Finally, based on indirect 3D reconstructions from the 2D views, we conjecture that all breast tumors considered in this study, benign and malignant, fractal or Euclidean, restrict their growth to 2-dimensional manifolds within the breast tissue.

Three-dimensional wavelet-based multifractal method: the need for revisiting the multifractal description of turbulence dissipation data.

We generalize the wavelet transform modulus maxima (WTMM) method to multifractal analysis of 3D random fields. This method is calibrated on synthetic 3D monofractal fractional Brownian fields and on 3D multifractal singular cascade measures as well as their random function counterpart obtained by fractional integration. Then we apply the 3D WTMM method to the dissipation field issued from 3D isotropic turbulence simulations. We comment on the need to revisit previous box-counting analyses which have failed to estimate correctly the corresponding multifractal spectra because of their intrinsic inability to master nonconservative singular cascade measures.

Generalizing the wavelet-based multifractal formalism to random vector fields: application to three-dimensional turbulence velocity and vorticity data.

We use singular value decomposition techniques to generalize the wavelet transform modulus maxima method to the multifractal analysis of vector-valued random fields. The method is calibrated on synthetic multifractal 2D vector measures and monofractal 3D fractional Brownian vector fields. We report the results of some application to the velocity and vorticity fields issued from 3D isotropic turbulence simulations. This study reveals the existence of an intimate relationship between the singularity spectra of these two vector fields which are found significantly more intermittent than previously estimated from longitudinal and transverse velocity increment statistics.