Motivational Salience Guides Attention to Valuable and Threatening Stimuli: Evidence from Behavior and Functional Magnetic Resonance Imaging.

Rewarding and aversive outcomes have opposing effects on behavior, facilitating approach and avoidance, although we need to accurately anticipate each type of outcome to behave effectively. Attention is biased toward stimuli that have been learned to predict either type of outcome, and it remains an open question whether such orienting is driven by separate systems for value- and threat-based orienting or whether there exists a common underlying mechanism of attentional control driven by motivational salience. Here, we provide a direct comparison of the neural correlates of value- and threat-based attentional capture after associative learning. Across multiple measures of behavior and brain activation, our findings overwhelmingly support a motivational salience account of the control of attention. We conclude that there exists a core mechanism of experience-dependent attentional control driven by motivational salience and that prior characterizations of attention as being value driven or supporting threat monitoring need to be revisited.

Measuring attention to reward as an individual trait: the value-driven attention questionnaire (VDAQ).

Reward history is a powerful determinant of what we pay attention to. This influence of reward on attention varies substantially across individuals, being related to a variety of personality variables and clinical conditions. Currently, the ability to measure and quantify attention-to-reward is restricted to the use of psychophysical laboratory tasks, which limits research into the construct in a variety of ways. In the present study, we introduce a questionnaire designed to provide a brief and accessible means of assessing attention-to-reward. Scores on the questionnaire correlate with other measures known to be related to attention-to-reward and predict performance on multiple laboratory tasks measuring the construct. In demonstrating this relationship, we also provide evidence that attention-to-reward as measured in the lab, an automatic and implicit bias in information processing, is related to overt behaviors and motivations in everyday life as assessed via the questionnaire. Variation in scores on the questionnaire is additionally associated with a distinct biomarker in brain connectivity, and the questionnaire exhibits acceptable test-retest reliability. Overall, the Value-Driven Attention Questionnaire (VDAQ) provides a useful proxy-measure of attention-to-reward that is much more accessible than typical laboratory assessments.

Success Factors for Tobacco Smoking Cessation Among Korean Female College Student Smokers.

The purpose of this study was to identify factors that successfully influence to quit smoking in female college students. The study was conducted from September 1, 2015 to December 31, 2017. Participants included 477 female student smokers, the average age was 20.87 years. The participants received smoking cessation counseling over the course of nine visits and via telephone calls for a period of 6 months. Follow-up assessments were conducted at 4, 6, 12, and 24 weeks. The factors significantly associated with successful smoking cessation included the average number of cigarettes smoked per day, age of first smoking experience, nicotine dependency, number of counseling sessions, confidence, and readiness. The most influential factor was the number of counseling sessions. Hence, this study suggested to promote continuous counseling and to introduce counseling programs tailored to female students, which might increase their success rate of quitting.

Multisystem Inflammatory Syndrome in Children Related to COVID-19: the First Case in Korea.

Since mid-April 2020, cases of multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 that mimics Kawasaki disease (KD) have been reported in Europe and North America. However, no cases have been reported in Korea. We describe an 11-year old boy with fever, abdominal pain, and diarrhea who developed hypotension requiring inotropes in intensive care unit. His blood test revealed elevated inflammatory markers, thrombocytopenia, hypoalbuminemia, and coagulopathy. Afterward, he developed signs of KD such as conjunctival injection, strawberry tongue, cracked lip, and coronary artery dilatation, and parenchymal consolidation without respiratory symptoms. Microbiological tests were all negative including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse transcription polymerase chain reaction. However, serum immunoglobulin G against SARS-CoV-2 was positive in repeated tests using enzyme-linked immunosorbent assay and fluorescent immunoassay. He was recovered well after intravenous immunoglobulin administration and discharged without complication on hospital day 13. We report the first Korean child who met all the criteria of MIS-C with features of incomplete KD or KD shock syndrome.

Neural evidence for automatic value-modulated approach behaviour.

Reward learning has the ability to bias both attention and behaviour. The current study presents behavioural and neural evidence that irrelevant responses evoked by previously reward-associated stimuli are more robustly represented in the motor system using a combined go/no-go and flankers task. Following a colour-reward association training, participants were instructed to respond to a central target only in a response-relevant context, while ignoring flankers that appeared either in a high-value or low-value colour. The motor cortex and cerebellum exhibited reduced activation to low-value flankers in a response-irrelevant context, consistent with goal-directed response suppression. However, these same regions exhibited similar activation to high-value flankers regardless of their response relevance, indicating less effective suppression, and the resulting interaction in motor cortex activation was strongly predicted by the influence of the flankers on behaviour. These findings suggest that associative reward learning produces a general approach bias, which is particularly evident when it conflicts with task goals, extending the principle of value-driven attention to stimulus-evoked responses in the motor system.

Test-retest reliability of value-driven attentional capture.

Attention is biased toward learned predictors of reward. The degree to which attention is automatically drawn to arbitrary reward cues has been linked to a variety of psychopathologies, including drug dependence, HIV-risk behaviors, depressive symptoms, and attention deficit/hyperactivity disorder. In the context of addiction specifically, attentional biases toward drug cues have been related to drug craving and treatment outcomes. Given the potential role of value-based attention in psychopathology, the ability to quantify the magnitude of such bias before and after a treatment intervention in order to assess treatment-related changes in attention allocation would be desirable. However, the test-retest reliability of value-driven attentional capture by arbitrary reward cues has not been established. In the present study, we show that an oculomotor measure of value-driven attentional capture produces highly robust test-retest reliability for a behavioral assessment, whereas the response time (RT) measure more commonly used in the attentional bias literature does not. Our findings provide methodological support for the ability to obtain a reliable measure of susceptibility to value-driven attentional capture at multiple points in time, and they highlight a limitation of RT-based measures that should inform the use of attentional-bias tasks as an assessment tool.

On the representational nature of value-driven spatial attentional biases.

Reward learning biases attention toward both reward-associated objects and reward-associated regions of space. The relationship between objects and space in the value-based control of attention, as well as the contextual specificity of space-reward pairings, remains unclear. In the present study, using a free-viewing task, we provide evidence of overt attentional biases toward previously rewarded regions of texture scenes that lack objects. When scrutinizing a texture scene, participants look more frequently toward, and spend a longer amount of time looking at, regions that they have repeatedly oriented to in the past as a result of performance feedback. These biases were scene specific, such that different spatial contexts produced different patterns of habitual spatial orienting. Our findings indicate that reinforcement learning can modify looking behavior via a representation that is purely spatial in nature in a context-specific manner. NEW & NOTEWORTHY The representational nature of space in the value-driven control of attention remains unclear. Here, we provide evidence for scene-specific overt spatial attentional biases following reinforcement learning, even though the scenes contained no objects. Our findings indicate that reinforcement learning can modify looking behavior via a representation that is purely spatial in nature in a context-specific manner.

Controllable Bipolar Doping of Graphene with 2D Molecular Dopants.

The fine control of graphene doping levels over a wide energy range remains a challenging issue for the electronic applications of graphene. Here, the controllable doping of chemical vapor deposited graphene, which provides a wide range of energy levels (shifts up to ± 0.5 eV), is demonstrated through physical contact with chemically versatile graphene oxide (GO) sheets, a 2D dopant that can be solution-processed. GO sheets are a p-type dopant due to their abundance of electron-withdrawing functional groups. To expand the energy window of GO-doped graphene, the GO surface is chemically modified with electron-donating ethylene diamine molecules. The amine-functionalized GO sheets exhibit strong n-type doping behaviors. In addition, the particular physicochemical characteristics of the GO sheets, namely their sheet sizes, number of layers, and degree of oxidation and amine functionality, are systematically varied to finely tune their energy levels. Finally, the tailor-made GO sheet dopants are applied into graphene-based electronic devices, which are found to exhibit improved device performances. These results demonstrate the potential of GO sheet dopants in many graphene-based electronics applications.

Aversive eye gaze during a speech in virtual environment in patients with social anxiety disorder.

OBJECTIVE: One of the main characteristics of social anxiety disorder is excessive fear of social evaluation. In such situations, anxiety can influence gaze behaviour. Thus, the current study adopted virtual reality to examine eye gaze pattern of social anxiety disorder patients while presenting different types of speeches. METHODS: A total of 79 social anxiety disorder patients and 51 healthy controls presented prepared speeches on general topics and impromptu speeches on self-related topics to a virtual audience while their eye gaze was recorded. Their presentation performance was also evaluated. RESULTS: Overall, social anxiety disorder patients showed less eye gaze towards the audience than healthy controls. Types of speech did not influence social anxiety disorder patients' gaze allocation towards the audience. However, patients with social anxiety disorder showed significant correlations between the amount of eye gaze towards the audience while presenting self-related speeches and social anxiety cognitions. CONCLUSION: The current study confirms that eye gaze behaviour of social anxiety disorder patients is aversive and that their anxiety symptoms are more dependent on the nature of topic.

A Wearable Wrist Band-Type System for Multimodal Biometrics Integrated with Multispectral Skin Photomatrix and Electrocardiogram Sensors.

Multimodal biometrics are promising for providing a strong security level for personal authentication, yet the implementation of a multimodal biometric system for practical usage need to meet such criteria that multimodal biometric signals should be easy to acquire but not easily compromised. We developed a wearable wrist band integrated with multispectral skin photomatrix (MSP) and electrocardiogram (ECG) sensors to improve the issues of collectability, performance and circumvention of multimodal biometric authentication. The band was designed to ensure collectability by sensing both MSP and ECG easily and to achieve high authentication performance with low computation, efficient memory usage, and relatively fast response. Acquisition of MSP and ECG using contact-based sensors could also prevent remote access to personal data. Personal authentication with multimodal biometrics using the integrated wearable wrist band was evaluated in 150 subjects and resulted in 0.2% equal error rate ( EER ) and 100% detection probability at 1% FAR (false acceptance rate) ( PD . 1 ), which is comparable to other state-of-the-art multimodal biometrics. An additional investigation with a separate MSP sensor, which enhanced contact with the skin, along with ECG reached 0.1% EER and 100% PD . 1 , showing a great potential of our in-house wearable band for practical applications. The results of this study demonstrate that our newly developed wearable wrist band may provide a reliable and easy-to-use multimodal biometric solution for personal authentication.

The Articulated Alar Rim Graft: Reengineering the Conventional Alar Rim Graft for Improved Contour and Support.

Surgical refinement of the wide nasal tip is challenging. Achieving an attractive, slender, and functional tip complex without destabilizing the lower nasal sidewall or deforming the contracture-prone alar rim is a formidable task. Excisional refinement techniques that rely upon incremental weakening of wide lower lateral cartilages (LLC) often destabilize the tip complex and distort tip contour. Initial destabilization of the LLC is usually further exacerbated by "shrink-wrap" contracture, which often leads to progressive cephalic retraction of the alar margin. The result is a misshapen tip complex accentuated by a conspicuous and highly objectionable nostril deformity that is often very difficult to treat. The "articulated" alar rim graft (AARG) is a modification of the conventional rim graft that improves treatment of secondary alar rim deformities, including postsurgical alar retraction (PSAR). Unlike the conventional alar rim graft, the AARG is sutured to the underlying tip complex to provide direct stationary support to the alar margin, thereby enhancing graft efficacy. When used in conjunction with a well-designed septal extension graft (SEG) to stabilize the central tip complex, lateral crural tensioning (LCT) to tighten the lower nasal sidewalls and minimize soft-tissue laxity, and lysis of scar adhesions to unfurl the retracted and scarred nasal lining, the AARG can eliminate PSAR in a majority of patients. The AARG is also highly effective for prophylaxis against alar retraction and in the treatment of most other contour abnormalities involving the alar margin. Moreover, the AARG requires comparatively little graft material, and complications are rare. We present a retrospective series of 47 consecutive patients treated with the triad of AARG, SEG, and LCT for prophylaxis and/or treatment of alar rim deformities. Outcomes were favorable in nearly all patients, and no complications were observed. We conclude the AARG is a simple and effective method for avoiding and correcting most alar rim deformities.

In Vitro Toxicity Screening of Fifty Complex Mixtures in HepG2 Cells.

To develop the risk prediction technology for mixture toxicity, a reliable and extensive dataset of experimental results is required. However, most published literature only provides data on combinations containing two or three substances, resulting in a limited dataset for predicting the toxicity of complex mixtures. Complex mixtures may have different mode of actions (MoAs) due to their varied composition, posing difficulty in the prediction using conventional toxicity prediction models, such as the concentration addition (CA) and independent action (IA) models. The aim of this study was to generate an experimental dataset comprising complex mixtures. To identify the target complex mixtures, we referred to the findings of the HBM4EU project. We identified three groups of seven to ten components that were commonly detected together in human bodies, namely environmental phenols, perfluorinated compounds, and heavy metal compounds, assuming these chemicals to have different MoAs. In addition, a separate mixture was added consisting of seven organophosphate flame retardants (OPFRs), which may have similar chemical structures. All target substances were tested for cytotoxicity using HepG2 cell lines, and subsequently 50 different complex mixtures were randomly generated with equitoxic mixtures of EC10 levels. To determine the interaction effect, we calculated the model deviation ratio (MDR) by comparing the observed EC10 with the predicted EC10 from the CA model, then categorized three types of interactions: antagonism, additivity, and synergism. Dose-response curves and EC values were calculated for all complex mixtures. Out of 50 mixtures, none demonstrated synergism, while six mixtures exhibited an antagonistic effect. The remaining mixtures exhibited additivity with MDRs ranging from 0.50 to 1.34. Our experimental data have been formatted to and constructed for the database. They will be utilized for further research aimed at developing the combined CA/IA approaches to support mixture risk assessment.

Primary rewards and aversive outcomes have comparable effects on attentional bias.

Attention is biased toward stimuli previously associated with reward. The same is true for aversive conditioning; stimuli previously associated with an aversive outcome also bias attention, suggesting that motivational salience guides attention. Most research that supports this conclusion has manipulated monetary gain-a secondary reinforcer-for reward learning, and electric shocks-a primary punisher-for aversive conditioning, making it difficult to directly compare their influence on attention. Therefore, in the present study, we matched for reinforcer dimensions by using primary taste as reinforcers/punishers and assessed their influence on attention. In a training phase, participants learned to associate three colors with sweet juice (reward), salt water (aversive), and no outcome (neutral), respectively. The two primary reinforcers were equated for valence based on choices made in a prior decision-making task. In a later test phase, these three colors were used for targets and distractors in a task in which participants oriented to a shape-defined target. An attentional bias in favor of the aversively conditioned and reward-associated colors was evident when comparing to the neutral color. Importantly, a direct comparison of rewarded and aversive stimuli revealed no significant differences. These results suggest that when matched for reinforcer dimensions and valence, reward and aversive outcomes bias attention in a similar manner and their effects are comparable, providing further evidence in support of the motivational salience account of learning-dependent attention. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

On the Relationship between Value- and Threat-Driven Attentional Capture and Approach-Avoidance Biases.

Reward learning and aversive conditioning have consequences for attentional selection, such that stimuli that come to signal reward and threat bias attention regardless of their valence. Appetitive and aversive stimuli have distinctive influences on response selection, such that they activate an approach and an avoidance response, respectively. However, whether the involuntary influence of reward- and threat-history-laden stimuli extends to the manner in which a response is directed remains unclear. Using a feedback-joystick task and a manikin task, which are common paradigms for examining valence-action bias, we demonstrate that reward- and threat-signalling stimuli do not modulate response selection. Stimuli that came to signal reward and threat via training biased attention and invigorated action in general, but they did not facilitate an approach and avoidance response, respectively. We conclude that attention can be biased towards a stimulus as a function of its prior association with reward or aversive outcomes without necessarily influencing approach vs. avoidance tendencies, such that the mechanisms underlying the involuntary control of attention and behaviour evoked by valent stimuli can be decoupled.

Statistical learning of distractor shape modulates attentional capture.

Physically salient but task-irrelevant stimuli have high attentional priority, although observers are able to capitalize on statistical regularities in the environment to more efficiently ignore such stimuli. Physically salient distractors that more frequently appear in a particular location are less distracting when they appear in this high probability location. Likewise, colors and orientations that are frequently associated with distractors become preferentially ignored with learning. Such statistically learned distractor suppression has been examined with respect to the frequency of elementary features across trials, and less is known about how statistics concerning the composition of distractor features within a trial influence attention, particularly with respect to how orientations combine to form shapes. Color, orientation, and location are also represented very early in vision, whereas more complex features such as shape are represented further downstream in the visual system; it remains unclear whether statistically leaned distractor suppression can operate over such downstream visual representations. In the present study, we demonstrate attentional capture by physically salient, shape-defined distractors that is reduced in magnitude for a high probability shape. Our findings demonstrate that statistical learning can modulate attentional priority at least at the level of basic shapes and is not restricted to modulations of priority at the earliest stages of visual information processing tied to elementary features.

Combined influence of valence and statistical learning on the control of attention II: Evidence from within-domain additivity.

Attention is biased in favor of stimuli that signal either threat or reward; this experience-dependent attentional bias develops via associative learning and persists into extinction. Physically salient yet task-irrelevant stimuli are also prioritized by the attention system, but the attentional priority of a physically salient distractor can be suppressed when it appears in a location in which it has been frequently encountered in the past. Similar effects of statistical learning on distractor suppression have been observed for distractors appearing in a predictable color. A pair of recent studies demonstrate that statistically learned distractor suppression and valence-based attentional biases combine additively, suggesting independent influences of learning on attentional priority. One limitation of these prior studies, however, is that the effects of statistical learning were defined with respect to spatial attention and the effects of associative learning with respect to feature-based attention. A strong version of the independence account would predict additive influences on attention even when both sources of priority are represented within a single domain of attentional control, which we tested in the present study. The attentional priority of a distractor was elevated when its color was previously associated with electric shock and reduced when its shape was frequently encountered as a distractor in a prior training phase, with these two influences on priority combining additively. Our findings provide strong evidence for the idea that statistical learning and valance-based associative learning exert independent influences on the control of attention, which has implications for contemporary theories of selection history.

Tailored Uniaxial Alignment of Nanowires Based on Off-Center Spin-Coating for Flexible and Transparent Field-Effect Transistors.

The alignment of nanowires (NWs) has been actively pursued for the production of electrical devices with high-operating performances. Among the generally available alignment processes, spin-coating is the simplest and fastest method for uniformly patterning the NWs. During spinning, the morphology of the aligned NWs is sensitively influenced by the resultant external drag and inertial forces. Herein, the assembly of highly and uniaxially aligned silicon nanowires (Si NWs) is achieved by introducing an off-center spin-coating method in which the applied external forces are modulated by positioning the target substrate away from the center of rotation. In addition, various influencing factors, such as the type of solvent, the spin acceleration time, the distance between the substrate and the center of rotation, and the surface energy of the substrate, are adjusted in order to optimize the alignment of the NWs. Next, a field-effect transistor (FET) incorporating the highly aligned Si NWs exhibits a high effective mobility of up to 85.7 cm2 V-1 s-1, and an on-current of 0.58 µA. Finally, the single device is enlarged and developed in order to obtain an ultrathin and flexible Si NW FET array. The resulting device has the potential to be widely expanded into applications such as wearable electronics and robotic systems.

Awareness and Needs of Smoking Cessation Services for Female Emotional Laborers, Parcel Delivery Workers, Transportation Workers, and Construction Workers in South Korea.

Although South Korea has implemented various smoking cessation services, women who are emotional laborers, as well as parcel delivery, transportation, and construction workers, have poor access to these services. This study evaluated the smoking-related characteristics of workers in these four occupations as well as the awareness of and need for smoking cessation services. In total 808 workers in these four occupations aged 19 years and above were recruited nationwide and had their data analyzed. The participants' age, marital status, number of work hours per week, job-related stress, age when they started smoking, average number of cigarettes a day, types of tobacco products, close relationships to others who smoke, number of attempts to quit smoking, plans to quit smoking, awareness of cessation services, prior utilization of cessation services, and need for cessation services were surveyed. Compared with parcel delivery workers, female emotional laborers and transportation and construction workers had more attempts to quit smoking, plans to quit smoking, and prior utilization of smoking cessation services, moreover, construction workers had a significantly lower awareness of smoking cessation services. Parcel delivery workers need smoking cessation programs, mobile applications to help them quit smoking, and improvements in their work environments. Cessation services and education should be promoted at workplaces and among managers.

Combined influence of valence and statistical learning on the control of attention: Evidence for independent sources of bias.

Selection history exerts a powerful influence on the control of attention. Stimuli signalling reward and punishment capture attention even when physically non-salient and task-irrelevant. Repeated presentation of a salient distractor at a particular location generates learned suppression, resulting in reduced attentional processing at that location. A debate in the field concerns whether different components of selection history influence attention via a common underlying mechanism of learning-dependent control or via distinct, independent mechanisms. We probed this question with a particular focus on reward/punishment history and learned suppression. Participants were trained to suppress a particular location (high probability distractor location) and associate colours with reward or no outcome (no-reward). In a subsequent task, reward and no-reward distractors appeared in all locations equally often. In a separate experiment, we replaced reward with electric shocks. Reward and shock distractors captured attention more strongly than no-reward and no-shock distractors irrespective of their location. Distractors appearing in the high probability location showed reduced capture irrespective of their type. The results imply that reward and punishment learning and learned suppression have independent influences on the attentional system.

Association of Stress Management with Success of Smoking Cessation in Korean Female Emotional Labor Workers for Service and Sales.

Emotional labor is paid work that involves managing and regulating one's emotions during the job including evoking and suppressing one's feelings. This study examined the factors associated with successful smoking cessation through tailored smoking cessation counseling including stress management among female emotional labor workers. The study was conducted from 1 September 2015 to 31 December 2017. A total of 2674 women registered in the Comprehensive Smoking Cessation Service System and were grouped as either emotional labor workers for service and sales (1002) or other occupations (1672) for analysis. The participants received nine sessions of face-to-face and telephone smoking cessation counseling over 6 months, and follow-up assessments were conducted 4, 6, 12, and 24 weeks after counseling. Smoking cessation counseling involved a stress management program comprising stress tests, depression tests, color therapy, and a buddy program including peer support. Factors associated with successful smoking cessation included the number of counseling sessions, motivation rulers (Importance, Confidence, Readiness), average daily smoking amount, expired carbon monoxide (CO), and nicotine dependence. The most associated factor was the number of counseling sessions. Since counseling focused on stress management, it was the most important factor in smoking cessation, and continuous counseling could help those wanting to quit smoking.