Detalhe da pesquisa
1.
Novel SARS-CoV-2 entry inhibitors, 2-anilinoquinazolin-4(3H)-one derivatives, show potency as SARS-CoV-2 antivirals in a human ACE2 transgenic mouse model.
J Med Virol
; 95(6): e28863, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37310127
2.
Discovery of 2-aminoquinolone acid derivatives as potent inhibitors of SARS-CoV-2.
Bioorg Med Chem Lett
; 85: 129214, 2023 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36870624
3.
Design, synthesis and biological evaluation of 2-aminoquinazolin-4(3H)-one derivatives as potential SARS-CoV-2 and MERS-CoV treatments.
Bioorg Med Chem Lett
; 39: 127885, 2021 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33662537
4.
Discovery of cyclic sulfonamide derivatives as potent inhibitors of SARS-CoV-2.
Bioorg Med Chem Lett
; 31: 127667, 2021 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33160024
5.
Colorectal cancer screening using a stool DNA-based SDC2 methylation test: a multicenter, prospective trial.
BMC Gastroenterol
; 21(1): 173, 2021 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33858326
6.
KRCA-0008 suppresses ALK-positive anaplastic large-cell lymphoma growth.
Invest New Drugs
; 38(5): 1282-1291, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31956933
7.
Identification of 4-anilino-6-aminoquinazoline derivatives as potential MERS-CoV inhibitors.
Bioorg Med Chem Lett
; 30(20): 127472, 2020 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32781216
8.
Synthesis and biological evaluation of 3-acyl-2-phenylamino-1,4-dihydroquinolin-4(1H)-one derivatives as potential MERS-CoV inhibitors.
Bioorg Med Chem Lett
; 29(23): 126727, 2019 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31624041
9.
Novel 2,4-diaminopyrimidines bearing fused tricyclic ring moiety for anaplastic lymphoma kinase (ALK) inhibitor.
Bioorg Med Chem Lett
; 27(10): 2185-2191, 2017 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28385505
10.
Novel 2,4-diaminopyrimidines bearing tetrahydronaphthalenyl moiety against anaplastic lymphoma kinase (ALK): Synthesis, in vitro, ex vivo, and in vivo efficacy studies.
Bioorg Med Chem Lett
; 26(7): 1720-5, 2016 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26923695
11.
Design, synthesis, and mode of action studies of a mitomycin tetramer inducing double activations with a single probe.
Bioorg Med Chem
; 24(18): 4023-4031, 2016 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27377862
12.
Discovery of novel tetrahydroisoquinoline-containing pyrimidines as ALK inhibitors.
Bioorg Med Chem
; 24(2): 207-19, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26712094
13.
Development of potent ALK inhibitor and its molecular inhibitory mechanism against NSCLC harboring EML4-ALK proteins.
Biochem Biophys Res Commun
; 464(3): 762-7, 2015 Aug 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-26168728
14.
Stereoselective construction of 2,6-cis-disubstituted tetrahydropyrans via intramolecular amide enolate alkylation: total synthesis of (-)-centrolobine.
J Org Chem
; 80(6): 3315-20, 2015 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25723100
15.
Synthesis and evaluation of novel 2,4-diaminopyrimidines bearing bicyclic aminobenzazepines for anaplastic lymphoma kinase (ALK) inhibitor.
Bioorg Med Chem Lett
; 25(18): 3992-8, 2015 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26235945
16.
Discovery of substituted 6-pheny-3H-pyridazin-3-one derivatives as novel c-Met kinase inhibitors.
Bioorg Med Chem Lett
; 24(21): 5093-7, 2014 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25282552
17.
Circulating α-klotho levels in CKD and relationship to progression.
Am J Kidney Dis
; 61(6): 899-909, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23540260
18.
Design and synthesis of novel 3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine derivatives as selective G-protein-coupled receptor kinase-2 and -5 inhibitors.
Bioorg Med Chem Lett
; 23(24): 6711-6, 2013 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24210504
19.
Novel bis-ortho-alkoxy-para-piperazinesubstituted-2,4-dianilinopyrimidines (KRCA-0008) as potent and selective ALK inhibitors for anticancer treatment.
Bioorg Med Chem Lett
; 23(22): 6192-6, 2013 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24095090
20.
Clinical outcomes, when matched at presentation, do not vary between adult-onset Henöch-Schönlein purpura nephritis and IgA nephropathy.
Kidney Int
; 82(12): 1304-12, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22895518