Detalhe da pesquisa
1.
Evaluation of RNAi therapeutics VIR-2218 and ALN-HBV for chronic hepatitis B: Results from randomized clinical trials.
J Hepatol
; 79(4): 924-932, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37290591
2.
Phase 3 Trial of RNAi Therapeutic Givosiran for Acute Intermittent Porphyria.
N Engl J Med
; 382(24): 2289-2301, 2020 06 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32521132
3.
Phase 1 Trial of an RNA Interference Therapy for Acute Intermittent Porphyria.
N Engl J Med
; 380(6): 549-558, 2019 02 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30726693
4.
Iron overload reduces adiponectin receptor expression via a ROS/FOXO1-dependent mechanism leading to adiponectin resistance in skeletal muscle cells.
J Cell Physiol
; 236(7): 5339-5351, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33432609
5.
No evidence for brain renin-angiotensin system activation during DOCA-salt hypertension.
Clin Sci (Lond)
; 135(2): 259-274, 2021 01 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-33404046
6.
A 52-week placebo-controlled trial of evolocumab in hyperlipidemia.
N Engl J Med
; 370(19): 1809-19, 2014 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24678979
7.
Efficacy and safety of evolocumab (AMG 145), a fully human monoclonal antibody to PCSK9, in hyperlipidaemic patients on various background lipid therapies: pooled analysis of 1359 patients in four phase 2 trials.
Eur Heart J
; 35(33): 2249-59, 2014 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24598985
8.
Mutation in the transcriptional coactivator EYA4 causes dilated cardiomyopathy and sensorineural hearing loss.
Nat Genet
; 37(4): 418-22, 2005 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-15735644
9.
Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 as monotherapy in patients with hypercholesterolaemia (MENDEL): a randomised, double-blind, placebo-controlled, phase 2 study.
Lancet
; 380(9858): 1995-2006, 2012 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-23141812
10.
Effect of a monoclonal antibody to PCSK9 on low-density lipoprotein cholesterol levels in statin-intolerant patients: the GAUSS randomized trial.
JAMA
; 308(23): 2497-506, 2012 Dec 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-23128163
11.
Normal reference ranges for urinary δ-aminolevulinic acid and porphobilinogen levels.
JIMD Rep
; 57(1): 85-93, 2021 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-33473344
12.
Renoprotective Effects of Small Interfering RNA Targeting Liver Angiotensinogen in Experimental Chronic Kidney Disease.
Hypertension
; 77(5): 1600-1612, 2021 05 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33719507
13.
The helix-loop-helix factors Id3 and E47 are novel regulators of adiponectin.
Circ Res
; 103(6): 624-34, 2008 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-18669923
14.
New Surgical Technique: Bidirectional Forehead Narrowing and Eyebrow Lifting Using Regional Flap Mobility.
Plast Reconstr Surg Glob Open
; 8(5): e2836, 2020 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-33154877
15.
Pharmacokinetics and Pharmacodynamics of the Small Interfering Ribonucleic Acid, Givosiran, in Patients With Acute Hepatic Porphyria.
Clin Pharmacol Ther
; 108(1): 63-72, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31994716
16.
Autologous Transplantation Using Donor Leukocytes Loaded Ex Vivo with Oncolytic Myxoma Virus Can Eliminate Residual Multiple Myeloma.
Mol Ther Oncolytics
; 18: 171-188, 2020 Sep 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32695875
17.
Strong and Sustained Antihypertensive Effect of Small Interfering RNA Targeting Liver Angiotensinogen.
Hypertension
; 73(6): 1249-1257, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31030610
18.
Patient Perspective on Acute Intermittent Porphyria with Frequent Attacks: A Disease with Intermittent and Chronic Manifestations.
Patient
; 11(5): 527-537, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29915990
19.
Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states.
Diabetes
; 55(8): 2256-64, 2006 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16873688
20.
Benefits of Heart Rate Slowing With Ivabradine in Patients With Systolic Heart Failure and Coronary Artery Disease.
Am J Cardiol
; 118(12): 1948-1953, 2016 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27780557