RESUMO
A possible involvement of chromosomal heterochromatic polymorphisms in propensity to cancer has been considered and discussed by several investigators who studied groups of patients presenting with different forms of malignancy. We report a cytogenetic study on the circulating lymphocytes of patients suffering from colorectal carcinoma, most of whom were of European origin. Significantly increased incidence of polymorphisms of chromosomes #1 and #9 was found, especially partial inversions (PI). Emphasis is given to the problem of selecting adequate controls, which must be as homogeneous as possible.
Assuntos
Adenocarcinoma/genética , Aberrações Cromossômicas , Neoplasias do Colo/genética , Neoplasias Retais/genética , Adulto , Idoso , Bandeamento Cromossômico , Cromossomos Humanos 1-3 , Cromossomos Humanos 6-12 e X , Suscetibilidade a Doenças , Feminino , Marcadores Genéticos , Humanos , Cariotipagem , Masculino , Pessoa de Meia-Idade , Polimorfismo GenéticoRESUMO
Juxta-centromeric fragility of chromosomes 1, 2, 9, 16, has been described at least thrice in unrelated patients in association with combined immunodeficiency. This association has been confirmed by our findings in both immunodeficient and cancer patients. In our opinion, both the fragility and the immunodeficiency are the results of persistent viral infections by certain DNA (i.e.: Herpes-, Papova-) viruses or RNA (retro-) viruses (i.e. HTLV), which are lymphotropic. The immunodeficiency may be due to virus-cell, cell to cell, or virus-virus interactions. According to our findings, centromeric fragility of chromosome 2 appears to have a particular oncogenic potential probably because of its location in proximity to immunoglobulins genes. We suggest that centromeric fragility of chromosomes 1, 2, 9, 16, may be one of the symptoms of an incipient Acquired Immunodeficiency Syndrome (AIDS) which will not necessarily develop fully.
Assuntos
Fragilidade Cromossômica , Cromossomos Humanos 1-3 , Cromossomos Humanos 16-18 , Cromossomos Humanos 6-12 e X , Síndromes de Imunodeficiência/genética , Neoplasias/genética , Síndrome da Imunodeficiência Adquirida/genética , Feminino , Humanos , Linfócitos/ultraestrutura , Masculino , Viroses/genéticaRESUMO
In a 36-year-old man with a left scrotal mass a tumor was found and excised through an inguinal incision, together with the testis and the contents of the inguinal canal, in continuity. Histological examination showed a liposarcoma of the spermatic cord. Only 55 cases of this rare scrotal tumor have been reported. The literature indicates that while there is a tendency to local recurrence, there have been no reports of distant metastases. It appears that radiotherapy and chemotherapy are not necessary in this condition.
Assuntos
Neoplasias dos Genitais Masculinos/cirurgia , Lipossarcoma/cirurgia , Cordão Espermático , Adulto , Neoplasias dos Genitais Masculinos/patologia , Humanos , Lipossarcoma/patologia , Masculino , PrognósticoRESUMO
Concomitance of different primary malignant neoplasms in the same individual has been observed and explained by several possible mechanisms. For urogenital malignancies in concomitance with lymphoid or with intestinal malignancies some data indicate that common etiologic factor(s) with pleiotropic effects may be involved. Concomitance of these particular different primary malignant neoplasms must therefore be kept in mind in the evaluation of patients' conditions.