Detalhe da pesquisa
1.
A phase 1 trial of AP30663, a KCa2 channel inhibitor in development for conversion of atrial fibrillation.
Br J Clin Pharmacol
; 90(4): 1027-1035, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-37990600
2.
Randomized placebo-controlled crossover study to assess tolerability and pharmacodynamics of zagociguat, a soluble guanylyl cyclase stimulator, in healthy elderly.
Br J Clin Pharmacol
; 89(12): 3606-3617, 2023 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37488930
3.
First-in-human trial to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of STR-324, a dual enkephalinase inhibitor for pain management.
Br J Clin Pharmacol
; 88(1): 103-114, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34046921
4.
Safety, pharmacokinetics and pharmacodynamics of HTL0009936, a selective muscarinic M1 -acetylcholine receptor agonist: A randomized cross-over trial.
Br J Clin Pharmacol
; 87(11): 4439-4449, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33891333
5.
First-in-man study to investigate safety, pharmacokinetics and exploratory pharmacodynamics of HTL0018318, a novel M1 -receptor partial agonist for the treatment of dementias.
Br J Clin Pharmacol
; 87(7): 2945-2955, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33351971
6.
Results of phase 2 trials exploring the safety and efficacy of omiganan in patients with human papillomavirus-induced genital lesions.
Br J Clin Pharmacol
; 86(11): 2133-2143, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31755993
7.
Cholinergic and serotonergic modulation of resting state functional brain connectivity in Alzheimer's disease.
Neuroimage
; 199: 143-152, 2019 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31112788
8.
Serotonergic and cholinergic modulation of functional brain connectivity: A comparison between young and older adults.
Neuroimage
; 169: 312-322, 2018 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29258890
9.
Pharmacokinetics and pharmacodynamics of a new highly concentrated intranasal midazolam formulation for conscious sedation.
Br J Clin Pharmacol
; 83(4): 721-731, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-27780297
10.
An anti-nicotinic cognitive challenge model using mecamylamine in comparison with the anti-muscarinic cognitive challenge using scopolamine.
Br J Clin Pharmacol
; 83(8): 1676-1687, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28217868
11.
Immunomodulating effects of the single bacterial strain therapy EDP1815 on innate and adaptive immune challenge responses - a randomized, placebo-controlled clinical trial.
Immunol Res
; 2024 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38748319
12.
Pharmacokinetics and central nervous system effects of the novel dual NK1 /NK3 receptor antagonist GSK1144814 in alcohol-intoxicated volunteers.
Br J Clin Pharmacol
; 75(5): 1328-39, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23067311
13.
First-in-human trial to assess safety, tolerability, pharmacokinetics, and pharmacodynamics of zagociguat (CY6463), a CNS-penetrant soluble guanylyl cyclase stimulator.
Clin Transl Sci
; 16(8): 1381-1395, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37118895
14.
Impact of oral administration of single strain Lactococcus lactis spp. cremoris on immune responses to keyhole limpet hemocyanin immunization and gut microbiota: A randomized placebo-controlled trial in healthy volunteers.
Front Immunol
; 13: 1009304, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36582231
15.
OX40L Inhibition Suppresses KLH-driven Immune Responses in Healthy Volunteers: A Randomized Controlled Trial Demonstrating Proof-of-Pharmacology for KY1005.
Clin Pharmacol Ther
; 111(5): 1121-1132, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35092305
16.
Safety and Pharmacokinetics of HTL0018318, a Novel M1 Receptor Agonist, Given in Combination with Donepezil at Steady State: A Randomized Trial in Healthy Elderly Subjects.
Drugs R D
; 21(3): 295-304, 2021 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-34164794
17.
Safety, pharmacokinetics and exploratory pro-cognitive effects of HTL0018318, a selective M1 receptor agonist, in healthy younger adult and elderly subjects: a multiple ascending dose study.
Alzheimers Res Ther
; 13(1): 87, 2021 04 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33883008
18.
The Effect of a 13-Valent Conjugate Pneumococcal Vaccine on Circulating Antibodies Against Oxidized LDL and Phosphorylcholine in Man, A Randomized Placebo-Controlled Clinical Trial.
Biology (Basel)
; 9(11)2020 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33105582
19.
Safety, pharmacokinetics, and pharmacodynamics of Gln-1062, a prodrug of galantamine.
Alzheimers Dement (N Y)
; 6(1): e12093, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33083515
20.
First Clinical Study with AP30663 - a KCa 2 Channel Inhibitor in Development for Conversion of Atrial Fibrillation.
Clin Transl Sci
; 13(6): 1336-1344, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32725783