Children value informativity over logic in word learning.

The question of how children learn the meanings of words has long puzzled philosophers and psychologists. As Quine famously pointed out, simply hearing a word in context reveals next to nothing about its meaning. How then do children learn to understand and use words correctly? Here, we show how learning theory can offer an elegant solution to this seemingly intractable puzzle in language acquisition. From it, we derived formal predictions about word learning in situations of Quinean ambiguity, and subsequently tested our predictions on toddlers, undergraduates, and developmental psychologists. The toddlers' performance was consistent both with our predictions and with the workings of implicit mechanisms that can facilitate the learning of meaningful lexical systems. Adults adopted a markedly different and likely suboptimal strategy. These results suggest one explanation for why early word learning can appear baffling: Adult intuitions may be a poor source of insight into how children learn.

Dual routes to cognitive flexibility: learning and response-conflict resolution in the dimensional change card sort task.

Cognitive control, the ability to align our actions with goals or context, is largely absent in children under four. How then are preschoolers able to tailor their behavior to best match the situation? Learning may provide an alternative route to context-sensitive responding. This study investigated this hypothesis in the Dimensional Change Card Sort (DCCS), a classic test of cognitive control that most under-fours fail. A training intervention based on learning theoretic principles proved highly effective: Three-year-olds who learned about DCCS rules and game contexts in a card-labeling task, subsequently transferred this knowledge to sorting in the DCCS, passing at more than 3 times the rate of controls (N = 47). This surprising finding reveals much about the nature of the developing mind.

Improving the reproducibility of findings by updating research methodology.

The literature discusses causes of low reproducibility of scientific publications. Our article adds another main cause-uncritical adherence to accepted research procedures. This is evident in: (1) anachronistically requiring researchers to base themselves on theoretical background even if the studies cited were not tested for reproducibility; (2) conducting studies suffering from a novelty effect bias; (3) forcing researchers who use data mining methods and field-based theory, with no preliminary theoretical rationale, to present a theoretical background that allegedly guided their work-as a precondition for publication of their findings. It is possible to increase research validity in relation to the above problems by the following means: (1) Conducting a longitudinal study on the same participants and only on them; (2) Trying to shorten the time period between laboratory experiments and those on humans, based on cost-benefit considerations, anchored in ethical norms; (3) Reporting the theoretical background in a causal modular format; (4) Giving incentives to those who meet the above criteria while moderating the pressure for fast output.

Can a biomarker for oxidative stress and antioxidant reserves identify frailty in geriatric trauma patients?

OBJECTIVE: Frailty is a state of systematic physiologic decline and reduced ability to recover from illness. There are no rapid quantitative biological measures to assess frailty. The study objective was to determine whether oxidation-reduction potential (ORP) is correlated with frailty score. METHODS: This prospective, observational cohort study was performed using plasma samples of geriatric trauma patients (≥65 years) admitted to a level I trauma center. Frailty was measured with the Canadian Study of Health and Aging (CSHA) Clinical Frailty Scale (7-point scale; 1 = robust health and 7 = severely frail). Plasma ORP was determined using the RedoxSYS™ system to measure static ORP (aggregate measure of oxidative stress) and capacity ORP (antioxidant reserves; log transformed). Spearman rank correlation (presented as rs) and ordinal logistic regression (presented as adjusted odds ratios, AOR) were used to examine the unadjusted and adjusted relationship between frailty score and ORP values. RESULTS: There were 93 geriatric trauma patients in our study. The majority (86%) had frailty scores 1-5, 11% were moderately frail and 3% were severely frail. There was a u-shaped relationship between ORP and frailty scale that became monotonic for scores 1-5. Each increase in frailty score demonstrated significant decreases in antioxidant reserves (log cORP rs = -0.26, p = 0.02) and nonsignificant increases in oxidative stress (sORP rs = 0.17, p = 0.15). After adjustment, variables significantly associated with frailty included log cORP (e.g., fewer antioxidant reserves, AOR: 0.70), age (AOR: 1.82), injury severity score (AOR: 0.50), admission lactate ≥2.5 mMol (AOR: 4.31), and alcohol use (AOR: 0.34). CONCLUSIONS: The amount of antioxidant reserves (cORP) appears to be a quantitative marker to differentiate the degree of frailty ranging from robust health to mild frailty in geriatric trauma patients. We propose that direct quantification of frailty by way of a biomarker for oxidative reserves could have application in emergent trauma situations.

The impact of stuttering on employment opportunities and job performance.

UNLABELLED: The purpose of this study was to examine the impact that stuttering has on job performance and employability. The method involved administration of a 17-item survey that was completed by 232 people who stutter, age 18 years or older. Results indicated that more than 70% of people who stutter agreed that stuttering decreases one's chances of being hired or promoted. More than 33% of people who stutter believed stuttering interferes with their job performance, and 20% had actually turned down a job or promotion because of their stuttering. Results also indicated that men and minorities were more likely to view stuttering as handicapping than were women and Caucasians. These findings suggest that people who stutter believe stuttering to be handicapping in the workplace. The results may be helpful for clinicians who work with people who stutter. EDUCATIONAL OBJECTIVES: The reader will be able to: (1) describe the impact that stuttering can have on employability and job performance and (2) be better able to explain how factors such as gender, ethnicity, and stuttering severity can impact the belief that stuttering is a handicapping condition.

N,N',N"-tris(dihydroxyphosphorylmethyl)-1,4,7-triazacyclononane (Deofix) - a high-affinity, high-specificity chelator for first transition series metal cations with significant deodorant, antimicrobial, and antioxidant activity.

Deofix, N,N',N"-tris(dihydroxyphosphorylmethyl)-1,4,7-triazacyclononane, is a high-affinity, high-specificity chelator for first transition series cations such as iron, zinc, manganese, and copper. A 1% solution in 50% ethanol was found to be significantly better at reducing underarm malodor than a solution of 0.3% Triclosan in 50% ethanol. Compared to a 50% alcohol control, Deofix was found to produce a significant reduction in malodor for at least 48 hours. Deofix appears to work by reducing the concentration of first transition series metal ions below the levels needed for microbial cell reproduction and by inhibiting oxidative processes by interfering with catalytic formation of free radicals. Deofix has very low levels of toxicity when measured via a number of screening techniques.

Giant enterolith in ileal diverticulum following ileoplastic bladder augmentation.

INTRODUCTION: When adhesions, internal hernias, malignant intra- and retro-peritoneal neoplasms are excluded in patients presenting with new onset constipation and abdominal mass appearance after previous abdominal surgery, other causes must be considered. PRESENTATION OF CASE: Giant enteroliths formed within ileal diverticula in the site of small bowel anastomosis may extrude and produce a palpable abdominal lump. Recent experience with such a patient is the basis of this report. DISCUSSION: Ileal diverticula with interior enteroliths may be suspected in patients presenting with an abdominal lump following previous small bowel resection. CONCLUSION: Open or laparoscopic assisted surgical resection of the involved segment is the treatment of choice.