Detalhe da pesquisa
1.
Discovery of Potent Pyrazoline-Based Covalent SARS-CoV-2 Main Protease Inhibitors.
Chembiochem
; 24(11): e202300116, 2023 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37069799
2.
Author Correction: Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex.
Nat Chem Biol
; 16(3): 361, 2020 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-31942047
3.
Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex.
Nat Chem Biol
; 16(1): 15-23, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31819272
4.
Ibrutinib plus lenalidomide and rituximab has promising activity in relapsed/refractory non-germinal center B-cell-like DLBCL.
Blood
; 134(13): 1024-1036, 2019 09 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-31331917
5.
The combination of ibrutinib and rituximab demonstrates activity in first-line follicular lymphoma.
Br J Haematol
; 189(4): 650-660, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32180219
6.
Structure-guided enzymology of the lipid A acyltransferase LpxM reveals a dual activity mechanism.
Proc Natl Acad Sci U S A
; 113(41): E6064-E6071, 2016 10 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27681620
7.
Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model.
Bioorg Med Chem Lett
; 26(3): 742-746, 2016 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26774655
8.
Identification and optimisation of 4,5-dihydrobenzo[1,2-d:3,4-d]bisthiazole and 4,5-dihydrothiazolo[4,5-h]quinazoline series of selective phosphatidylinositol-3 kinase alpha inhibitors.
Bioorg Med Chem Lett
; 25(17): 3575-81, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26199119
9.
mRNA Display Identifies Potent, Paralog-Selective Peptidic Ligands for ARID1B.
ACS Chem Biol
; 19(5): 1142-1150, 2024 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38655884
10.
Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation.
Bioorg Med Chem Lett
; 23(13): 3741-8, 2013 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23726034
11.
Structure guided optimization of a fragment hit to imidazopyridine inhibitors of PI3K.
Bioorg Med Chem Lett
; 23(16): 4652-6, 2013 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23820386
12.
Crystal Structures of Inhibitor-Bound Main Protease from Delta- and Gamma-Coronaviruses.
Viruses
; 15(3)2023 03 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36992489
13.
Identification of Brain-Penetrant ATP-Competitive mTOR Inhibitors for CNS Syndromes.
J Med Chem
; 66(13): 9095-9119, 2023 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37399505
14.
Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance.
Nat Commun
; 13(1): 3556, 2022 06 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35729165
15.
Identification of NVP-CLR457 as an Orally Bioavailable Non-CNS-Penetrant pan-Class IA Phosphoinositol-3-Kinase Inhibitor.
J Med Chem
; 65(12): 8345-8379, 2022 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35500094
16.
Using a clinical judgement model to understand the impact of validated pain assessment tools for burn clinicians and adult patients in the ICU: A multi-methods study.
Burns
; 47(1): 110-126, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33277094
17.
Identification and structure-activity relationship of 2-morpholino 6-(3-hydroxyphenyl) pyrimidines, a class of potent and selective PI3 kinase inhibitors.
Bioorg Med Chem Lett
; 20(23): 6895-8, 2010 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21035331
18.
A polyomavirus peptide binds to the capsid VP1 pore and has potent antiviral activity against BK and JC polyomaviruses.
Elife
; 92020 01 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31960795
19.
SWOG S1400B (NCT02785913), a Phase II Study of GDC-0032 (Taselisib) for Previously Treated PI3K-Positive Patients with Stage IV Squamous Cell Lung Cancer (Lung-MAP Sub-Study).
J Thorac Oncol
; 14(10): 1839-1846, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31158500
20.
Rationally Designed PI3Kα Mutants to Mimic ATR and Their Use to Understand Binding Specificity of ATR Inhibitors.
J Mol Biol
; 429(11): 1684-1704, 2017 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28433539