Detalhe da pesquisa
1.
Discovery of mobocertinib, a potent, oral inhibitor of EGFR exon 20 insertion mutations in non-small cell lung cancer.
Bioorg Med Chem Lett
; 80: 129084, 2023 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36423823
2.
Computational and Functional Analyses of HER2 Mutations Reveal Allosteric Activation Mechanisms and Altered Pharmacologic Effects.
Cancer Res
; 83(9): 1531-1542, 2023 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35503682
3.
Discovery of Novel, Potent Inhibitors of Hydroxy Acid Oxidase 1 (HAO1) Using DNA-Encoded Chemical Library Screening.
J Med Chem
; 64(10): 6730-6744, 2021 05 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-33955740
4.
Bispecific Estrogen Receptor α Degraders Incorporating Novel Binders Identified Using DNA-Encoded Chemical Library Screening.
J Med Chem
; 64(8): 5049-5066, 2021 04 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33844532
5.
Novel Autotaxin Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis: A Clinical Candidate Discovered Using DNA-Encoded Chemistry.
J Med Chem
; 63(14): 7840-7856, 2020 07 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32584034
6.
Novel Small Molecule Inhibitors of Choline Kinase Identified by Fragment-Based Drug Discovery.
J Med Chem
; 59(2): 671-86, 2016 Jan 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-26700752
7.
Discovery of Brigatinib (AP26113), a Phosphine Oxide-Containing, Potent, Orally Active Inhibitor of Anaplastic Lymphoma Kinase.
J Med Chem
; 59(10): 4948-64, 2016 05 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-27144831
8.
Ponatinib inhibits polyclonal drug-resistant KIT oncoproteins and shows therapeutic potential in heavily pretreated gastrointestinal stromal tumor (GIST) patients.
Clin Cancer Res
; 20(22): 5745-5755, 2014 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25239608
9.
Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors.
J Med Chem
; 56(3): 1023-40, 2013 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-23302067
10.
Application of MM-GB/SA and WaterMap to SRC Kinase Inhibitor Potency Prediction.
ACS Med Chem Lett
; 3(2): 94-9, 2012 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900440