Detalhe da pesquisa
1.
The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism.
Cell
; 165(7): 1632-1643, 2016 Jun 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-27315480
2.
Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation.
Mol Cell
; 77(3): 656-668.e5, 2020 02 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32004469
3.
Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor.
Nature
; 561(7724): 492-497, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30209400
4.
Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex.
Nature
; 555(7694): 121-125, 2018 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29466332
5.
Two distinct domains of the glucagon-like peptide-1 receptor control peptide-mediated biased agonism.
J Biol Chem
; 293(24): 9370-9387, 2018 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29717000
6.
O-GlcNAc Engineering of GPCR Peptide-Agonists Improves Their Stability and in Vivo Activity.
J Am Chem Soc
; 141(36): 14210-14219, 2019 09 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31418572
7.
Allostery and Biased Agonism at Class B G Protein-Coupled Receptors.
Chem Rev
; 117(1): 111-138, 2017 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27040440
8.
Genetically encoded photocross-linkers determine the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor (GLP-1R).
J Biol Chem
; 292(17): 7131-7144, 2017 04 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-28283573
9.
A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures.
Mol Pharmacol
; 89(3): 335-47, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26700562
10.
Differential impact of amino acid substitutions on critical residues of the human glucagon-like peptide-1 receptor involved in peptide activity and small-molecule allostery.
J Pharmacol Exp Ther
; 353(1): 52-63, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25630467
11.
Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery.
Proc Natl Acad Sci U S A
; 109(45): 18607-12, 2012 Nov 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-23091034
12.
Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) differentially regulates orthosteric but not allosteric agonist binding and function.
J Biol Chem
; 287(6): 3659-73, 2012 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-22147709
13.
Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activation.
J Biol Chem
; 287(6): 3642-58, 2012 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-22147710
14.
Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function.
Biochem Soc Trans
; 41(1): 172-9, 2013 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23356279
15.
Socs3b regulates the development and function of innate immune cells in zebrafish.
Front Immunol
; 14: 1119727, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36969252
16.
Polymorphism and ligand dependent changes in human glucagon-like peptide-1 receptor (GLP-1R) function: allosteric rescue of loss of function mutation.
Mol Pharmacol
; 80(3): 486-97, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21616920
17.
Modulation of the glucagon-like peptide-1 receptor signaling by naturally occurring and synthetic flavonoids.
J Pharmacol Exp Ther
; 336(2): 540-50, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21075839
18.
Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug screening.
Mol Pharmacol
; 78(3): 456-65, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20547734
19.
Structure and Dynamics of Adrenomedullin Receptors AM1 and AM2 Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins.
ACS Pharmacol Transl Sci
; 3(2): 263-284, 2020 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32296767
20.
Vascular and molecular pharmacology of the metabolically stable CGRP analogue, SAX.
Eur J Pharmacol
; 829: 85-92, 2018 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29653090