Detalhe da pesquisa
1.
Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity.
J Biol Chem
; 296: 100568, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33753169
2.
Development of a chemical probe against NUDT15.
Nat Chem Biol
; 16(10): 1120-1128, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32690945
3.
Targeting OGG1 arrests cancer cell proliferation by inducing replication stress.
Nucleic Acids Res
; 48(21): 12234-12251, 2020 12 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33211885
4.
ATM/Wip1 activities at chromatin control Plk1 re-activation to determine G2 checkpoint duration.
EMBO J
; 36(14): 2161-2176, 2017 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28607002
5.
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
Nature
; 508(7495): 215-21, 2014 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24695224
6.
Corrigendum: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
Nature
; 544(7651): 508, 2017 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28447629
7.
Vinylic MIDA Boronates: New Building Blocks for the Synthesis of Aza-Heterocycles.
Chemistry
; 21(20): 7394-8, 2015 May 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25809883
8.
Chemical strategies for development of ATR inhibitors.
Expert Rev Mol Med
; 16: e10, 2014 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-24810715
9.
Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel.
iScience
; 27(2): 108907, 2024 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38318365
10.
Optimization of N-Piperidinyl-Benzimidazolone Derivatives as Potent and Selective Inhibitors of 8-Oxo-Guanine DNA Glycosylase 1.
ChemMedChem
; 18(1): e202200310, 2023 01 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36128847
11.
Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function.
Science
; 376(6600): 1471-1476, 2022 06 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35737787
12.
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress.
Nat Cancer
; 3(2): 156-172, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35228749
13.
MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia.
Cancer Res
; 81(22): 5733-5744, 2021 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34593524
14.
Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses.
Viruses
; 12(12)2020 12 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33322045
15.
Correction: A patient-derived xenograft pre-clinical trial reveals treatment responses and a resistance mechanism to karonudib in metastatic melanoma.
Cell Death Dis
; 11(2): 99, 2020 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32029719
16.
A patient-derived xenograft pre-clinical trial reveals treatment responses and a resistance mechanism to karonudib in metastatic melanoma.
Cell Death Dis
; 9(8): 810, 2018 07 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-30042422
17.
Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation.
Science
; 362(6416): 834-839, 2018 11 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-30442810
18.
A versatile synthesis of diverse 3,4-fused cinnolines via the base-catalysed condensation of 2-amino-2'-nitrobiaryls.
Chem Commun (Camb)
; (24): 2506-8, 2007 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-17563811
19.
Structure-metabolism-relationships in the microsomal clearance of piperazin-1-ylpyridazines.
Medchemcomm
; 8(7): 1553-1560, 2017 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30108867
20.
dUTPase inhibition augments replication defects of 5-Fluorouracil.
Oncotarget
; 8(14): 23713-23726, 2017 Apr 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28423595