Detalhe da pesquisa
1.
Identification of 2-Sulfonyl/Sulfonamide Pyrimidines as Covalent Inhibitors of WRN Using a Multiplexed High-Throughput Screening Assay.
Biochemistry
; 62(14): 2147-2160, 2023 07 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37403936
2.
Biochemical and structural basis for the pharmacological inhibition of nuclear hormone receptor PPARγ by inverse agonists.
J Biol Chem
; 298(11): 102539, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36179791
3.
Isocitrate dehydrogenase (IDH) mutations promote a reversible ZEB1/microRNA (miR)-200-dependent epithelial-mesenchymal transition (EMT).
J Biol Chem
; 287(50): 42180-94, 2012 Dec 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-23038259
4.
Generating a Murine PTEN Null Cell Line to Discover the Key Role of p110ß-PAK1 in Castration-Resistant Prostate Cancer Invasion.
Mol Cancer Res
; 21(12): 1317-1328, 2023 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37606694
5.
Covalent ERα Antagonist H3B-6545 Demonstrates Encouraging Preclinical Activity in Therapy-Resistant Breast Cancer.
Mol Cancer Ther
; 21(6): 890-902, 2022 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35642432
6.
Blocking PI3K p110ß Attenuates Development of PTEN-Deficient Castration-Resistant Prostate Cancer.
Mol Cancer Res
; 20(5): 673-685, 2022 05 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35105671
7.
MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells.
J Transl Med
; 9: 30, 2011 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-21426561
8.
Estrogen Receptor Covalent Antagonists: The Best Is Yet to Come.
Cancer Res
; 79(8): 1740-1745, 2019 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30952631
9.
Nonclinical pharmacokinetics and in vitro metabolism of H3B-6545, a novel selective ERα covalent antagonist (SERCA).
Cancer Chemother Pharmacol
; 83(1): 151-160, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30386887
10.
Author Correction: Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer.
Nat Commun
; 10(1): 2527, 2019 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31164653
11.
The emerging role of miR-200 family of microRNAs in epithelial-mesenchymal transition and cancer metastasis.
RNA Biol
; 5(3): 115-9, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-19182522
12.
Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex.
Nat Commun
; 8: 15522, 2017 05 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-28541300
13.
Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer.
Nat Commun
; 8(1): 103, 2017 07 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28740126
14.
Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms.
J Vis Exp
; (106): e52879, 2015 Dec 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26710000
15.
An F876L mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (enzalutamide).
Cancer Discov
; 3(9): 1030-43, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23842682
16.
Modulation of immunosurveillance by tumor-intrinsic genomic alterations.
Immunotherapy
; 9(16): 1305-1307, 2017 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29185394
17.
Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization.
Nat Med
; 17(9): 1101-8, 2011 Aug 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21822286
18.
Targeting the transforming growth factor-beta signalling pathway in metastatic cancer.
Eur J Cancer
; 46(7): 1232-40, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20307969
19.
Imaging transforming growth factor-beta signaling dynamics and therapeutic response in breast cancer bone metastasis.
Nat Med
; 15(8): 960-6, 2009 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-19597504
20.
The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2.
J Biol Chem
; 283(22): 14910-4, 2008 May 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-18411277