Detalhe da pesquisa
1.
A qPCR to quantify Wolbachia from few Onchocerca volvulus microfilariae as a surrogate for adult worm histology in clinical trials of antiwolbachial drugs.
Parasitol Res
; 121(4): 1199-1206, 2022 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-35006317
2.
Eosinophils Are an Endogenous Source of Interleukin-4 during Filarial Infections and Contribute to the Development of an Optimal T Helper 2 Response.
J Innate Immun
; 16(1): 159-172, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38354709
3.
Combinations of the azaquinazoline anti-Wolbachia agent, AWZ1066S, with benzimidazole anthelmintics synergise to mediate sub-seven-day sterilising and curative efficacies in experimental models of filariasis.
Front Microbiol
; 15: 1346068, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38362501
4.
Potential of Nucleic Acid Receptor Ligands to Improve Vaccination Efficacy against the Filarial Nematode Litomosoides sigmodontis.
Vaccines (Basel)
; 11(5)2023 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37243070
5.
The efficacy of the benzimidazoles oxfendazole and flubendazole against Litomosoides sigmodontis is dependent on the adaptive and innate immune system.
Front Microbiol
; 14: 1213143, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37440891
6.
Filarial nematode phenotypic screening cascade to identify compounds with anti-parasitic activity for drug discovery optimization.
Int J Parasitol Drugs Drug Resist
; 19: 89-97, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35834918
7.
Discovery of Substituted Di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines as Novel Macrofilaricidal Compounds for the Treatment of Human Filarial Infections.
J Med Chem
; 65(16): 11388-11403, 2022 08 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-35972896
8.
Macrophages Mediate Increased CD8 T Cell Inflammation During Weight Loss in Formerly Obese Mice.
Front Endocrinol (Lausanne)
; 11: 257, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32411095
9.
Corallopyronin A for short-course anti-wolbachial, macrofilaricidal treatment of filarial infections.
PLoS Negl Trop Dis
; 14(12): e0008930, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33284808
10.
Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro.
PLoS Negl Trop Dis
; 14(7): e0008427, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32628671
11.
In vivo efficacy of the boron-pleuromutilin AN11251 against Wolbachia of the rodent filarial nematode Litomosoides sigmodontis.
PLoS Negl Trop Dis
; 14(1): e0007957, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31986143
12.
Short-course quinazoline drug treatments are effective in the Litomosoides sigmodontis and Brugia pahangi jird models.
Int J Parasitol Drugs Drug Resist
; 12: 18-27, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31869759
13.
In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae.
PLoS Negl Trop Dis
; 13(8): e0007636, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31381563
14.
Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds.
PLoS Negl Trop Dis
; 13(1): e0006320, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30650105
15.
Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity.
PLoS Negl Trop Dis
; 13(2): e0007159, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30818326
16.
Preclinical development of an oral anti-Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis.
Sci Transl Med
; 11(483)2019 03 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30867321
17.
Boron-Pleuromutilins as Anti- Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis.
J Med Chem
; 62(5): 2521-2540, 2019 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30730745
18.
Combinations of registered drugs reduce treatment times required to deplete Wolbachia in the Litomosoides sigmodontis mouse model.
PLoS Negl Trop Dis
; 12(1): e0006116, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29300732