Effects of regular sauna bathing in conjunction with exercise on cardiovascular function: a multi-arm, randomized controlled trial.

Regular exercise and sauna bathing have each been shown to improve cardiovascular function in clinical populations. However, experimental data on the cardiovascular adaptations to regular exercise in conjunction with sauna bathing in the general population are lacking. Therefore, we compared the effects of exercise and sauna bathing to regular exercise using a multi-arm randomized controlled trial. Participants (n = 47) aged 49 ± 9 with low physical activity levels and at least one traditional cardiovascular disease (CVD) risk factor were randomly assigned (1:1:1) to guideline-based regular exercise and 15-min postexercise sauna (EXS), guideline-based regular exercise (EXE), or control (CON) for 8 wk. The primary outcomes were blood pressure (BP) and cardiorespiratory fitness (CRF). Secondary outcomes included fat mass, total cholesterol levels, and arterial stiffness. EXE had a greater change in CRF (+6.2 mL/kg/min; 95% CI, +4.2 to +8.3 mL/kg/min) and fat mass but no differences in BP when compared with CON. EXS displayed greater change in CRF (+2.7 mL/kg/min; 95% CI, +0.2 to +5.3 mL/kg/min), lower systolic BP (-8.0 mmHg; 95% CI, -14.6 to -1.4 mmHg), and lower total cholesterol levels compared with EXE. Regular exercise improved CRF and body composition in sedentary adults with CVD risk factors. However, when combined with exercise, sauna bathing demonstrated a substantially supplementary effect on CRF, systolic BP, and total cholesterol levels. Sauna bathing is a valuable lifestyle tool that complements exercise for improving CRF and decreasing systolic BP. Future research should focus on the duration and frequency of exposure to ascertain the dose-response relationship.

Climate change induces carbon loss of arable mineral soils in boreal conditions.

One-fourth of the global soil organic carbon (SOC) is stored in the boreal region, where climate change is predicted to be faster than the global average. Planetary warming is accelerated if climate change promotes SOC release into the atmosphere as carbon dioxide. However, the soil carbon-climate feedbacks have been poorly confirmed by SOC measurements despite their importance on global climate. In this study, we used data collected as part of the Finnish arable soil monitoring program to study the influence of climate change, management practices, and historical land use on changes in SOC content using a Bayesian approach. Topsoil samples (n = 385) collected nationwide in 2009 and 2018 showed that SOC content has decreased at the rate of 0.35% year-1 on average. Based on the Bayesian modeling of our data, we can say with a certainty of 79%-91% that increase in summertime (May-Sep) temperature has resulted in SOC loss while increased precipitation has resulted in SOC loss with a certainty of 90%-97%. The exact percentages depend on the climate dataset used. Historical land use was found to influence the SOC content for decades after conversion to cropland. Former organic soils with a high SOC-to-fine-fraction ratio were prone to high SOC loss. In fields with long cultivation history (>100 years), however, the SOC-to-fine-fraction ratio had stabilized to approximately 0.03-0.04 and the changes in SOC content leveled off. Our results showed that, although arable SOC sequestration can be promoted by diversifying crop rotations and by cultivating perennial grasses, it is unlikely that improved management practices are sufficient to counterbalance the climate change-induced SOC losses in boreal conditions. This underlines the importance of the reduction of greenhouse gas emissions to avoid the acceleration of planetary warming.

Methodological choices in size and density fractionation of soil carbon reserves - A case study on wood fiber sludge amended soils.

Soil organic carbon (SOC) is in the focus of research due to its central role in regulating climate and maintaining fertility and resilience of soils. Methodologically, shifting from whole soil C measurements to specific SOC fractions increases possibility to detect small changes in the vast SOC storage, and enhances estimation of SOC stability. However, SOC fractionation schemes are numerous and variable. In this study, deionized water and sodium hexametaphosphate (SHMP) were compared in soil dispersion by separating soils into coarse (0.25-2 mm), medium (0.063-0.25 mm) and fine (<0.063 mm) size fractions. The first two fractions were further separated by density (1.8 g cm-3) to obtain free particulate organic C (POC) and mineral associated organic C (MOC). The approach was applied to a clay and a silt loam soil with and without wood fiber sludge amendment to follow the added C. Aggregate disruption was enhanced with SHMP in comparison to water, but the effect was small and the use of SHMP decreased recovery of SOC, wherefore water was preferred. In both soils, 5-10 % of SOC occurred as coarse POC, 1-3% as coarse MOC, 5 % as medium POC, 10 % as medium MOC, and 70-85 % as fine MOC. The added C resided in the POC fractions with an indication of minor accumulation to the fine MOC in the clay soil. Longer time frame with repeated C additions would be needed to increase the stable MOC storages though saturation of the MOC reserve may hinder accumulation in the silt loam low in fines.

Mortality and subsequent fractures of patients with olecranon fractures compared to other upper extremity osteoporotic fractures.

Background: The incidence rate of olecranon fractures is highest in the elderly population. The aim of this study was to determine whether patients with olecranon fractures have similar demographic and risk characteristics compared to patients with osteoporotic upper extremity fractures. Methods: A retrospective data analysis was performed with diagnoses for olecranon fracture, distal radius fracture and proximal humerus fracture between 2014 and 2016. Results: A total of 157 olecranon, 1022 distal radius and 451 proximal humerus fractures were identified. The risk of mortality after olecranon and distal radius fractures was comparable but statistically significantly higher after proximal humerus fractures (HR 1.97, 95% CI 1.19-3.27). The risk of subsequent osteoporotic fractures after an olecranon fracture was 10% at 1 year and 14% at 5 years and the risks did not differ statistically after a proximal humerus fracture, 6% and 11% (HR 0.65, 95% CI 0.40-1.06). After a distal radius fracture, the risks were statistically significantly lower: 2% and 5% (HR 0.35, 95% CI 0.22-0.56). Discussion: Patients with olecranon fractures have essentially similar demographic characteristics compared to patients with distal radius fractures, but the probability for a subsequent fracture is significantly higher and more comparable to patients with proximal humerus fractures.

A Comprehensive Approach to PROMs in Elective Orthopedic Surgery: Comparing Effect Sizes across Patient Subgroups.

Background: There is limited knowledge regarding the comparative patient-reported outcomes (PROMs) and effect sizes (ESs) across orthopedic elective surgery. Methods: All patient data between January 2020 and December 2022 were collected, and treatment outcomes assessed as a PROM difference between baseline and one-year follow-up. The cohort was divided into subgroups (hand, elbow, shoulder, spine, hip, knee, and foot/ankle). The PROM ESs were calculated for each patient separately, and patients with ES > 0.5 were considered responders. Results: In total, 7695 patients were operated on. The mean ES across all patient groups was 1.81 (SD 1.41), and the largest ES was observed in shoulder patients and the smallest in hand patients. Overall, shoulder, hip, and knee patients had a larger ES compared to hand, spine, and foot/ankle patients (p < 0.0001). The proportion of positive responders ranged between 91-94% in the knee, shoulder, and hip, and 69-70% in the hand, spine, and foot/ankle subgroups. Conclusions: The ESs are generally high throughout elective orthopedic surgery. However, based on our institutional observations, shoulder, hip, and knee patients experience larger treatment effects compared to hand, spine, and foot/ankle patients, among whom there are also more non-responders. The expected treatment outcomes should be clearly communicated to patients when considering elective surgery. Because of the study limitations, the results should be approached with some caution.

Short communication: Predicting blood plasma non-esterified fatty acid and beta-hydroxybutyrate concentrations from cow milk-addressing systematic issues in modelling.

Negative energy status in early lactation is linked to a variety of metabolic disorders, reduced fertility, and decreased milk production. To improve the energy status of cows by breeding and management, the identification of negative energy status is crucial. While biomarkers such as non-esterified fatty acid (NEFA) concentration and beta-hydroxybutyrate (BHB) in blood plasma could be used to identify a negative energy state, measuring them directly from blood is both invasive and expensive. In this work, we developed prediction equations for blood plasma NEFA and BHB levels based on mid-IR spectral measurements of milk. The models were fitted using partial least squares regression and evaluated using both cross-validation and independent-herd validation. A total of 3 183 spectral records from 606 lactations originating from three different herds were utilised. R2 values of 0.53 (RMSE = 0.206 mmol/l, RMSE of cross-validation (RMSECV) 0.217 mmol/l) for NEFA and 0.63 (RMSE = 0.326 mmol/l, RMSECV = 0.353 mmol/l) for BHB were obtained. Furthermore, relatively similar prediction accuracies were found for BHB (RMSE of prediction (RMSEP) 0.411 mmol/l and 0.422 mmol/l) and NEFA (RMSEP = 0.186 mmol/l and 0.221 mmol/l) when model training was done using two herds and validated on the third herd. The results from the model fits confirm that it is possible to build blood plasma BHB and NEFA models based on mid-IR spectra that are sufficiently accurate for practical use.

Standalone sauna vs exercise followed by sauna on cardiovascular function in non-naïve sauna users: A comparison of acute effects.

BACKGROUND AND AIMS: Sauna bathing and aerobic exercise have each been shown to affect cardiovascular function. However, direct comparisons between standalone sauna bathing and a combination of exercise and sauna on vascular indices remain limited. Therefore, we conducted a cross-over study using matched durations to explore the hemodynamic changes of sauna exposure when compared to a combination of aerobic exercise and sauna exposure. METHODS: Participants (N = 72) with at least one cardiovascular risk factor underwent, on two separate occasions: (a) a 30-minute sauna at 75°C (SAUNA) and (b) the combination of a 15-minute cycling exercise at 75% maximum heart rate followed by 15-minute sauna exposure (EX+SAUNA). Relative changes to arterial stiffness (PWV), augmentation index (Alx), brachial systolic and diastolic blood pressure (SBP and DBP), central SBP (cSBP), mean arterial pressure (MAP), and heart rate (HR) were compared PRE-POST and pre- to 30-minutes post-intervention (PRE-POST30). RESULTS: Baseline SBP and DBP were 143 (SD 18) mmHg and 86 (SD 10) mmHg, respectively. From PRE-POST, SAUNA had lower DBP (mean difference [95% CI] 2.5 [1.0, 4.1], P = .002) and MAP (2.5 [0.6, 4.3], P = .01). However, EX+SAUNA had lower SBP (-2.7 [-4.8, -0.5], P = .02), DBP (-1.8 [-3.3, -0.4], P = .01), and MAP (-2.0 [-3.5, -0.5], P = .009) PRE-POST30. There were no statistically significant differences between SAUNA and EX+SAUNA for other measured parameters. CONCLUSION: This study demonstrated that when matched for duration, EX+SAUNA and SAUNA elicit comparable acute hemodynamic alterations in middle-aged participants with cardiovascular risk factors. The sauna is a suitable option for acute blood pressure reductions in those who are unable to perform aerobic exercise, and may be a viable lifestyle treatment option to improve blood pressure control.