Detalhe da pesquisa
1.
The connecting cilium inner scaffold provides a structural foundation that protects against retinal degeneration.
PLoS Biol
; 20(6): e3001649, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35709082
2.
Gene augmentation therapy attenuates retinal degeneration in a knockout mouse model of Fam161a retinitis pigmentosa.
Mol Ther
; 31(10): 2948-2961, 2023 10 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37580905
3.
Enhancer of Zeste Homolog 2 (EZH2) Contributes to Rod Photoreceptor Death Process in Several Forms of Retinal Degeneration and Its Activity Can Serve as a Biomarker for Therapy Efficacy.
Int J Mol Sci
; 22(17)2021 Aug 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34502238
4.
Animal modelling for inherited central vision loss.
J Pathol
; 238(2): 300-10, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26387748
5.
FAM161A, associated with retinitis pigmentosa, is a component of the cilia-basal body complex and interacts with proteins involved in ciliopathies.
Hum Mol Genet
; 21(23): 5174-84, 2012 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22940612
6.
Fine-tuning FAM161A gene augmentation therapy to restore retinal function.
EMBO Mol Med
; 16(4): 805-822, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38504136
7.
Reduction of choroidal neovascularization in mice by adeno-associated virus-delivered anti-vascular endothelial growth factor short hairpin RNA.
J Gene Med
; 14(11): 632-41, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23080553
8.
Lentiviral Vectors for Ocular Gene Therapy.
Pharmaceutics
; 14(8)2022 Jul 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-36015231
9.
In conditions of limited chromophore supply rods entrap 11-cis-retinal leading to loss of cone function and cell death.
Hum Mol Genet
; 18(7): 1266-75, 2009 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19147682
10.
Quantification of the early pupillary dilation kinetic to assess rod and cone activity.
Sci Rep
; 11(1): 9549, 2021 05 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33953266
11.
A new mouse model for retinal degeneration due to Fam161a deficiency.
Sci Rep
; 11(1): 2030, 2021 01 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33479377
12.
Lentiviral mediated RPE65 gene transfer in healthy hiPSCs-derived retinal pigment epithelial cells markedly increased RPE65 mRNA, but modestly protein level.
Sci Rep
; 10(1): 8890, 2020 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32483256
13.
An in vitro Model of Human Retinal Detachment Reveals Successive Death Pathway Activations.
Front Neurosci
; 14: 571293, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33324144
14.
[Gene therapy for hereditary eye diseases: where are we?]. / Ophtalmologie. Thérapie génique des rétinopathies héréditaires: premiers résultats.
Rev Med Suisse
; 5(186): 118-23, 2009 Jan 14.
Artigo
em Francês
| MEDLINE | ID: mdl-19238930
15.
Maturation of the Pupil Light Reflex Occurs Until Adulthood in Mice.
Front Neurol
; 10: 56, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30778330
16.
Rai1 frees mice from the repression of active wake behaviors by light.
Elife
; 62017 05 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28548639
17.
Evaluation of tolerance to lentiviral LV-RPE65 gene therapy vector after subretinal delivery in non-human primates.
Transl Res
; 188: 40-57.e4, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28754419
18.
Bmi1 loss produces an increase in astroglial cells and a decrease in neural stem cell population and proliferation.
J Neurosci
; 25(24): 5774-83, 2005 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15958744
19.
Lentiviral gene transfer of RPE65 rescues survival and function of cones in a mouse model of Leber congenital amaurosis.
PLoS Med
; 3(10): e347, 2006 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17032058
20.
Determination of Rod and Cone Influence to the Early and Late Dynamic of the Pupillary Light Response.
Invest Ophthalmol Vis Sci
; 57(6): 2501-8, 2016 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27152964