Detalhe da pesquisa
1.
Novel 2-[thio]acetamide linked quinazoline/1,2,4-triazole/chalcone hybrids: Design, synthesis, and anticancer activity as EGFR inhibitors and apoptotic inducers.
Arch Pharm (Weinheim)
; : e2300627, 2024 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38593298
2.
Triple targeting of mutant EGFRL858R/T790M, COX-2, and 15-LOX: design and synthesis of novel quinazolinone tethered phenyl urea derivatives for anti-inflammatory and anticancer evaluation.
J Enzyme Inhib Med Chem
; 38(1): 2199166, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37038884
3.
Synthesis of 1,2,4-triazole and 1,3,4-oxadiazole derivatives as inhibitors for STAT3 enzymes of breast cancer.
Arch Pharm (Weinheim)
; 356(11): e2300345, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37661355
4.
Quinazolinone dimers as a potential new class of safer Kv1 inhibitors: Overcoming hERG, sodium and calcium channel affinities.
Bioorg Chem
; 115: 105264, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34416509
5.
Design and synthesis of novel quinazolinones conjugated ibuprofen, indole acetamide, or thioacetohydrazide as selective COX-2 inhibitors: anti-inflammatory, analgesic and anticancer activities.
J Enzyme Inhib Med Chem
; 36(1): 1810-1828, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34338135
6.
Quinazoline-tethered hydrazone: A versatile scaffold toward dual anti-TB and EGFR inhibition activities in NSCLC.
Arch Pharm (Weinheim)
; 354(12): e2100281, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34585758
7.
1,4-Dihydroquinazolin-3(2H)-yl benzamide derivatives as anti-inflammatory and analgesic agents with an improved gastric profile: Design, synthesis, COX-1/2 inhibitory activity and molecular docking study.
Bioorg Chem
; 84: 76-86, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30481648
8.
Synthesis, in vivo and in silico evaluation of novel 2,3-dihydroquinazolin-4(1H)-one derivatives as potential anticonvulsant agents.
Drug Dev Res
; 80(3): 343-352, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30565722
9.
Synthesis, Anticonvulsant Activity, and SAR Study of Novel 4-Quinazolinone Derivatives.
Arch Pharm (Weinheim)
; 350(2)2017 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-28177550
10.
Synthesis and in vitro anticancer evaluation of some 4,6-diamino-1,3,5-triazine-2-carbohydrazides as Rad6 ubiquitin conjugating enzyme inhibitors.
Bioorg Med Chem Lett
; 26(8): 2030-4, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26965855
11.
Gold nanoparticle conjugated Rad6 inhibitor induces cell death in triple negative breast cancer cells by inducing mitochondrial dysfunction and PARP-1 hyperactivation: Synthesis and characterization.
Nanomedicine
; 12(3): 745-757, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26563438
12.
Corrigendum to "Gold nanoparticle conjugated Rad6 inhibitor induces cell death in triple negative breast cancer cells by inducing mitochondrial dysfunction and PARP-1 hyperactivation: Synthesis and characterization" [Nanomedicine 12 (3) (2016), 745-757].
Nanomedicine
; 18: 426, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30726707
13.
Design, synthesis and in vitro anticancer evaluation of 4,6-diamino-1,3,5-triazine-2-carbohydrazides and -carboxamides.
Bioorg Med Chem Lett
; 23(24): 6886-9, 2013 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24153206
14.
Magic shotgun approach to anti-inflammatory pharmacotherapy: Synthesis of novel thienopyrimidine monomers/heterodimer as dual COX-2 and 15-LOX inhibitors endowed with potent antioxidant activity.
Eur J Med Chem
; 260: 115724, 2023 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37611534
15.
Synthesis of new multitarget-directed ligands containing thienopyrimidine nucleus for inhibition of 15-lipoxygenase, cyclooxygenases, and pro-inflammatory cytokines.
Eur J Med Chem
; 256: 115443, 2023 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37182334
16.
Phenylalanyl tRNA synthetase (PheRS) substrate mimics: design, synthesis, molecular dynamics and antimicrobial evaluation.
RSC Adv
; 12(4): 2511-2524, 2022 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35425259
17.
Novel 1,2,4-triazine-quinoline hybrids: The privileged scaffolds as potent multi-target inhibitors of LPS-induced inflammatory response via dual COX-2 and 15-LOX inhibition.
Eur J Med Chem
; 219: 113457, 2021 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33892270
18.
Design, computational studies, synthesis and in vitro antimicrobial evaluation of benzimidazole based thio-oxadiazole and thio-thiadiazole analogues.
BMC Chem
; 15(1): 58, 2021 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34711258
19.
Synthesis of new 2,3-dihydroquinazolin-4(1H)-one derivatives for analgesic and anti-inflammatory evaluation.
Arch Pharm (Weinheim)
; 343(5): 274-81, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20232372
20.
Design, synthesis and biological evaluation of novel quinazoline-2,4-diones conjugated with different amino acids as potential chitin synthase inhibitors.
Eur J Med Chem
; 152: 560-569, 2018 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-29763805