Detalhe da pesquisa
1.
Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation.
Proc Natl Acad Sci U S A
; 121(1): e2307086120, 2024 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38147543
2.
Characterization of JNJ-2482272 [4-(4-Methyl-2-(4-(Trifluoromethyl)Phenyl)Thiazole-5-yl) Pyrimidine-2-Amine] As a Strong Aryl Hydrocarbon Receptor Activator in Rat and Human.
Drug Metab Dispos
; 50(8): 1064-1076, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35680134
3.
Quantitative Mass Spectrometry Imaging to Study Drug Distribution in the Intestine Following Oral Dosing.
Anal Chem
; 93(4): 2144-2151, 2021 02 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33470103
4.
Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor.
J Pharmacol Exp Ther
; 372(3): 339-353, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31818916
5.
Discovery of N-arylpyrroles as agonists of GPR120 for the treatment of type II diabetes.
Bioorg Med Chem Lett
; 28(5): 841-846, 2018 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29456108
6.
Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia.
J Pharmacol Exp Ther
; 354(3): 471-82, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26177655
7.
Erratum to "Discovery of N-arylpyrroles as agonists of GPR120 for the treatment of type II diabetes" Bioorg. Med. Chem. Lett. 28 (2018) [841-846].
Bioorg Med Chem Lett
; 28(9): 1676-1678, 2018 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29605534
8.
Discovery of a Series of Substituted 1H-((1,2,3-Triazol-4-yl)methoxy)pyrimidines as Brain Penetrants and Potent GluN2B-Selective Negative Allosteric Modulators.
J Med Chem
; 66(4): 2877-2892, 2023 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36757100
9.
Prediction of oral pharmacokinetics of cMet kinase inhibitors in humans: physiologically based pharmacokinetic model versus traditional one-compartment model.
Drug Metab Dispos
; 39(3): 383-93, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21098644
10.
Pre-clinical characterization of aryloxypyridine amides as histamine H3 receptor antagonists: identification of candidates for clinical development.
Bioorg Med Chem Lett
; 20(14): 4210-4, 2010 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20561786
11.
Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin-1 Antagonists: Discovery of JNJ-54717793.
ACS Med Chem Lett
; 11(10): 2002-2009, 2020 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33062185
12.
Design, Synthesis, and Preclinical Evaluation of 3-Methyl-6-(5-thiophenyl)-1,3-dihydro-imidazo[4,5-b]pyridin-2-ones as Selective GluN2B Negative Allosteric Modulators for the Treatment of Mood Disorders.
J Med Chem
; 63(17): 9181-9196, 2020 09 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32787105
13.
Discovery of a Gut-Restricted JAK Inhibitor for the Treatment of Inflammatory Bowel Disease.
J Med Chem
; 63(6): 2915-2929, 2020 03 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-32134643
14.
An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms.
Cancer Res
; 67(9): 4408-17, 2007 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17483355
15.
Pharmacologic properties of AG-012986, a pan-cyclin-dependent kinase inhibitor with antitumor efficacy.
Mol Cancer Ther
; 7(4): 818-28, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18413795
16.
1H-Pyrrolo[3,2-b]pyridine GluN2B-Selective Negative Allosteric Modulators.
ACS Med Chem Lett
; 10(3): 261-266, 2019 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30891123
17.
Discovery of Imidazo[1,2-a]pyrazines and Pyrazolo[1,5-c]pyrimidines as TARP γ-8 Selective AMPAR Negative Modulators.
ACS Med Chem Lett
; 10(3): 267-272, 2019 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30891124
18.
Pharmacokinetic-pharmacodynamic modeling of biomarker response and tumor growth inhibition to an orally available cMet kinase inhibitor in human tumor xenograft mouse models.
Drug Metab Dispos
; 36(7): 1267-74, 2008 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-18381487
19.
Lead Optimization of 5-Aryl Benzimidazolone- and Oxindole-Based AMPA Receptor Modulators Selective for TARP γ-8.
ACS Med Chem Lett
; 9(8): 821-826, 2018 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30128074
20.
A Dipolar Cycloaddition Reaction To Access 6-Methyl-4,5,6,7-tetrahydro-1H-[1,2,3]triazolo[4,5-c]pyridines Enables the Discovery Synthesis and Preclinical Profiling of a P2X7 Antagonist Clinical Candidate.
J Med Chem
; 61(1): 207-223, 2018 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-29211470