Pesquisa | BVS IEC

1.

Design principles for cyclin K molecular glue degraders.

Kozicka, Zuzanna; Suchyta, Dakota J; Focht, Vivian; Kempf, Georg; Petzold, Georg; Jentzsch, Marius; Zou, Charles; Di Genua, Cristina; Donovan, Katherine A; Coomar, Seemon; Cigler, Marko; Mayor-Ruiz, Cristina; Schmid-Burgk, Jonathan L; Häussinger, Daniel; Winter, Georg E; Fischer, Eric S; Slabicki, Mikolaj; Gillingham, Dennis; Ebert, Benjamin L; Thomä, Nicolas H.

Nat Chem Biol ; 20(1): 93-102, 2024 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-37679459

2.

Structural mechanism of cGAS inhibition by the nucleosome.

Pathare, Ganesh R; Decout, Alexiane; Glück, Selene; Cavadini, Simone; Makasheva, Kristina; Hovius, Ruud; Kempf, Georg; Weiss, Joscha; Kozicka, Zuzanna; Guey, Baptiste; Melenec, Pauline; Fierz, Beat; Thomä, Nicolas H; Ablasser, Andrea.

Nature ; 587(7835): 668-672, 2020 11.

Artigo em Inglês | MEDLINE | ID: mdl-32911482

3.

The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K.

Slabicki, Mikolaj; Kozicka, Zuzanna; Petzold, Georg; Li, Yen-Der; Manojkumar, Manisha; Bunker, Richard D; Donovan, Katherine A; Sievers, Quinlan L; Koeppel, Jonas; Suchyta, Dakota; Sperling, Adam S; Fink, Emma C; Gasser, Jessica A; Wang, Li R; Corsello, Steven M; Sellar, Rob S; Jan, Max; Gillingham, Dennis; Scholl, Claudia; Fröhling, Stefan; Golub, Todd R; Fischer, Eric S; Thomä, Nicolas H; Ebert, Benjamin L.

Nature ; 585(7824): 293-297, 2020 09.

Artigo em Inglês | MEDLINE | ID: mdl-32494016

4.

Rational discovery of molecular glue degraders via scalable chemical profiling.

Mayor-Ruiz, Cristina; Bauer, Sophie; Brand, Matthias; Kozicka, Zuzanna; Siklos, Marton; Imrichova, Hana; Kaltheuner, Ines H; Hahn, Elisa; Seiler, Kristina; Koren, Anna; Petzold, Georg; Fellner, Michaela; Bock, Christoph; Müller, André C; Zuber, Johannes; Geyer, Matthias; Thomä, Nicolas H; Kubicek, Stefan; Winter, Georg E.

Nat Chem Biol ; 16(11): 1199-1207, 2020 11.

Artigo em Inglês | MEDLINE | ID: mdl-32747809

5.

Publisher Correction: Rational discovery of molecular glue degraders via scalable chemical profiling.

Mayor-Ruiz, Cristina; Bauer, Sophie; Brand, Matthias; Kozicka, Zuzanna; Siklos, Marton; Imrichova, Hana; Kaltheuner, Ines H; Hahn, Elisa; Seiler, Kristina; Koren, Anna; Petzold, Georg; Fellner, Michaela; Bock, Christoph; Müller, André C; Zuber, Johannes; Geyer, Matthias; Thomä, Nicolas H; Kubicek, Stefan; Winter, Georg E.

Nat Chem Biol ; 17(3): 361, 2021 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-33452497

6.

Gluing the pieces together.

Kozicka, Zuzanna.

Science ; 382(6672): 779-780, 2023 11 17.

Artigo em Inglês | MEDLINE | ID: mdl-37972173

7.

Readout of histone methylation by Trim24 locally restricts chromatin opening by p53.

Isbel, Luke; Iskar, Murat; Durdu, Sevi; Weiss, Joscha; Grand, Ralph S; Hietter-Pfeiffer, Eric; Kozicka, Zuzanna; Michael, Alicia K; Burger, Lukas; Thomä, Nicolas H; Schübeler, Dirk.

Nat Struct Mol Biol ; 30(7): 948-957, 2023 07.

Artigo em Inglês | MEDLINE | ID: mdl-37386214

8.

Haven't got a glue: Protein surface variation for the design of molecular glue degraders.

Kozicka, Zuzanna; Thomä, Nicolas Holger.

Cell Chem Biol ; 28(7): 1032-1047, 2021 07 15.

Artigo em Inglês | MEDLINE | ID: mdl-33930325

9.

Taking the Brakes Off Targeted Protein Degradation.

Kozicka, Zuzanna; Petzold, Georg; Thomä, Nicolas H.

Cell Chem Biol ; 27(1): 16-18, 2020 01 16.

Artigo em Inglês | MEDLINE | ID: mdl-31951816

10.

Mechanisms of OCT4-SOX2 motif readout on nucleosomes.

Michael, Alicia K; Grand, Ralph S; Isbel, Luke; Cavadini, Simone; Kozicka, Zuzanna; Kempf, Georg; Bunker, Richard D; Schenk, Andreas D; Graff-Meyer, Alexandra; Pathare, Ganesh R; Weiss, Joscha; Matsumoto, Syota; Burger, Lukas; Schübeler, Dirk; Thomä, Nicolas H.

Science ; 368(6498): 1460-1465, 2020 06 26.

Artigo em Inglês | MEDLINE | ID: mdl-32327602

BVS IEC

Instituto Evandro Chagas

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