Detalhe da pesquisa
1.
Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase.
J Neurochem
; 125(1): 144-56, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23237322
2.
Attenuated Abeta42 responses to low potency gamma-secretase modulators can be overcome for many pathogenic presenilin mutants by second-generation compounds.
J Biol Chem
; 286(17): 15240-51, 2011 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-21357415
3.
Concomitant gain and loss of function pathomechanisms in C9ORF72 amyotrophic lateral sclerosis.
Life Sci Alliance
; 4(4)2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33619157
4.
Generation and deposition of Aß43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease.
EMBO Mol Med
; 8(5): 458-65, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26988102