Detalhe da pesquisa
1.
Combining nano-differential scanning fluorimetry and microscale thermophoresis to investigate VDAC1 interaction with small molecules.
J Enzyme Inhib Med Chem
; 38(1): 2121821, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36650907
2.
The intrinsically disordered N-terminus of the voltage-dependent anion channel.
PLoS Comput Biol
; 17(2): e1008750, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33577583
3.
A Deep Dive into VDAC1 Conformational Diversity Using All-Atom Simulations Provides New Insights into the Structural Origin of the Closed States.
Int J Mol Sci
; 23(3)2022 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35163095
4.
1D NMR WaterLOGSY as an efficient method for fragment-based lead discovery.
J Enzyme Inhib Med Chem
; 34(1): 1218-1225, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-31286785
5.
Performance of protein-ligand docking with simulated chemical shift perturbations.
J Chem Inf Model
; 55(2): 275-83, 2015 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-25357133
6.
[Fragment-based screening: a promising avenue for drug design]. / Le criblage de fragments - Une voie prometteuse pour la conception de médicaments.
Med Sci (Paris)
; 31(2): 197-202, 2015 Feb.
Artigo
em Francês
| MEDLINE | ID: mdl-25744267
7.
A combination of spin diffusion methods for the determination of protein-ligand complex structural ensembles.
Angew Chem Int Ed Engl
; 54(22): 6511-5, 2015 May 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25877959
8.
Protein-ligand structure guided by backbone and side-chain proton chemical shift perturbations.
J Biomol NMR
; 60(2-3): 147-56, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25256941
9.
NMR-based analysis of protein-ligand interactions.
Anal Bioanal Chem
; 406(4): 943-56, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23591643
10.
Cancer selective cell death induction by a bivalent CK2 inhibitor targeting the ATP site and the allosteric αD pocket.
iScience
; 27(2): 108903, 2024 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38318383
11.
Preparation of miniaturized hydrophilic affinity monoliths: Towards a reduction of non-specific interactions and an increased target protein density.
J Chromatogr A
; 1687: 463670, 2023 Jan 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36463648
12.
Linkers in fragment-based drug design: an overview of the literature.
Expert Opin Drug Discov
; 18(9): 987-1009, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37466331
13.
A fragment-based drug discovery strategy applied to the identification of NDM-1 ß-lactamase inhibitors.
Eur J Med Chem
; 240: 114599, 2022 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35841882
14.
Fragment Linking Strategies for Structure-Based Drug Design.
J Med Chem
; 63(20): 11420-11435, 2020 10 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32539387
15.
Miniaturized weak affinity chromatography for ligand identification of nanodiscs-embedded G-protein coupled receptors.
Anal Chim Acta
; 1113: 26-35, 2020 May 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-32340666
16.
Synthesis, Optimization, Antifungal Activity, Selectivity, and CYP51 Binding of New 2-Aryl-3-azolyl-1-indolyl-propan-2-ols.
Pharmaceuticals (Basel)
; 13(8)2020 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32784450
17.
NMR investigation of protein-ligand interactions for G-protein coupled receptors.
Future Med Chem
; 11(14): 1811-1825, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31287732
18.
Modification and Biological Evaluation of a Series of 1,5-Diaryl-1,2,4-triazole Compounds as Novel Agents against Pancreatic Cancer Metastasis through Targeting Myoferlin.
J Med Chem
; 62(10): 4949-4966, 2019 05 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31026162
19.
2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 1. Identification of an Allosteric Binding Site.
J Med Chem
; 62(4): 1803-1816, 2019 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30689953
20.
Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors.
Sci Rep
; 9(1): 15893, 2019 11 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31685885