RESUMO
OBJECTIVES: To review the evidence for the application of tools for dengue outbreak prediction/detection and trend monitoring in passive and active disease surveillance systems in order to develop recommendations for endemic countries and identify important research needs. METHODS: This systematic literature review followed the protocol of a review from 2008, extending the systematic search from January 2007 to February 2013 on PubMed, EMBASE, CDSR, WHOLIS and Lilacs. Data reporting followed the PRISMA statement. The eligibility criteria comprised (i) population at risk of dengue, (ii) dengue disease surveillance, (iii) outcome of surveillance described and (iv) empirical data evaluated. The analysis classified studies based on the purpose of the surveillance programme. The main limitation of the review was expected publication bias. RESULTS: A total of 1116 papers were identified of which 36 articles were included in the review. Four cohort-based prospective studies calculated expansion factors demonstrating remarkable levels of underreporting in the surveillance systems. Several studies demonstrated that enhancement methods such as laboratory support, sentinel-based reporting and staff motivation contributed to improvements in dengue reporting. Additional improvements for passive surveillance systems are possible by incorporating simple data forms/entry/electronic-based reporting; defining clear system objectives; performing data analysis at the lowest possible level (e.g. district); seeking regular data feedback. Six studies showed that serotype changes were positively correlated with the number of reported cases or with dengue incidence, with lag times of up to 6 months. Three studies found that data on internet searches and event-based surveillance correlated well with the epidemic curve derived from surveillance data. CONCLUSIONS: Passive surveillance providing the baseline for outbreak alert should be strengthened and appropriate threshold levels for outbreak alerts investigated. Additional enhancement tools such as syndromic surveillance, laboratory support and motivation strategies can be added. Appropriate alert signals need to be identified and integrated into a risk assessment tool. Shifts in dengue serotypes/genotype or electronic event-based surveillance have also considerable potential as indicator in dengue surveillance. Further research on evidence-based response strategies and cost-effectiveness is needed.
Assuntos
Dengue/epidemiologia , Surtos de Doenças , Vigilância da População , HumanosRESUMO
OBJECTIVE: To systematically review the literature on the effectiveness of Bacillus thuringiensis israelensis (Bti), when used as a single agent in the field, for the control of dengue vectors. METHOD: Systematic literature search of the published and grey literature was carried out using the following databases: MEDLINE, EMBASE, Global Health, Web of Science, the Cochrane Library, WHOLIS, ELDIS, the New York Academy of Medicine Gray Literature Report, Africa-Wide and Google. All results were screened for duplicates and assessed for eligibility. Relevant data were extracted, and a quality assessment was conducted using the CONSORT 2010 checklist. RESULTS: Fourteen studies satisfied the eligibility criteria, incorporating a wide range of interventions and outcome measures. Six studies were classified as effectiveness studies, and the remaining eight examined the efficacy of Bti in more controlled settings. Twelve (all eight efficacy studies and 4 of 6 effectiveness studies) reported reductions in entomological indices with an average duration of control of 2-4 weeks. The two effectiveness studies that did not report significant entomological reductions were both cluster-randomised study designs that utilised basic interventions such as environmental management or general education on environment control practices in their respective control groups. Only one study described a reduction in entomological indices together with epidemiological data, reporting one dengue case in the treated area compared to 15 dengue cases in the untreated area during the observed study period. CONCLUSION: While Bti can be effective in reducing the number of immature Aedes in treated containers in the short term, there is very limited evidence that dengue morbidity can be reduced through the use of Bti alone. There is currently insufficient evidence to recommend the use of Bti as a single agent for the long-term control of dengue vectors and prevention of dengue fever. Further studies examining the role of Bti in combination with other strategies to control dengue vectors are warranted.
Assuntos
Aedes/microbiologia , Bacillus thuringiensis/classificação , Agentes de Controle Biológico , Dengue/prevenção & controle , Insetos Vetores/microbiologia , Controle de Mosquitos/métodos , Animais , Dengue/parasitologia , Dengue/transmissão , Humanos , Resultado do TratamentoRESUMO
OBJECTIVES: To determine whether medical staff at PHC level would have the time to take up additional activities such as 1-day fever camps for active VL case detection. METHODS: This article assessed the workload of health staff of different professional categories working at health facilities in Bangladesh, India and Nepal. Data were collected from different sites in high endemic VL areas. The study population was the health staff of government health facilities at all levels. Workload indicators of staffing need (WISN) software were adopted to carry out the analysis of staff workload and their availability in the selected health facility. The WISN difference and WISN ratio for a particular health facility were calculated from actual staffing available and calculated staffing requirement. RESULTS: The results showed a mixed picture of the availability of health workers. In most settings of Bangladesh and India, physicians with or without laboratory technicians would have time for active case detection. In Nepal, this would be performed by trained nurses and paramedical personnel. CONCLUSION: If all vacant posts were filled, active case detection could be performed more easily. The elimination programme can be scaled up with the current staffing levels in the endemic areas with some short training if and when necessary.
Assuntos
Pessoal de Saúde/organização & administração , Necessidades e Demandas de Serviços de Saúde/organização & administração , Leishmaniose Visceral/diagnóstico , Carga de Trabalho/normas , Bangladesh , Pessoal de Saúde/normas , Necessidades e Demandas de Serviços de Saúde/normas , Humanos , Índia , Nepal , Atenção Primária à Saúde/organização & administração , Atenção Primária à Saúde/normasRESUMO
Although, when applied under controlled conditions in India and Nepal, indoor residual spraying (IRS) has been found to reduce sandfly densities significantly, it is not known if IRS will be as effective when applied generally in these countries, via the national programmes for the elimination of visceral leishmaniasis. The potential benefits and limitations of national IRS programmes for the control of sandflies were therefore evaluated in the districts of Vaishali (in the Indian state of Bihar), Sarlahi (in Nepal) and Sunsari (also in Nepal). The use of technical guidelines, levels of knowledge and skills related to spraying operations, insecticide bio-availability on the sprayed surfaces, concentrations of the insecticide on the walls of sprayed houses, insecticide resistance, and the effectiveness of spraying, in terms of reducing sandfly densities within sprayed houses (compared with those found in unsprayed sentinel houses or control villages) were all explored. It was observed that IRS programme managers, at district and subdistrict levels in India and Nepal, used the relevant technical guidelines and were familiar with the procedures for IRS operation. The performance of the spraying activities, however, showed important deficiencies. The results of bio-assays and the chemical analysis of samples from sprayed walls indicated substandard spraying and suboptimal concentrations of insecticide on sprayed surfaces. This was particularly obvious at one of the Nepali study sites (Sunsari district), where no significant vector reduction was achieved. Sandfly resistance to the insecticide used in India (DDT) was widespread but the potential vectors in Nepal remained very susceptible towards a pyrethroid similar to the one used there. The overall short-term effectiveness of IRS was found to be satisfactory in two of the three study sites (in terms of reduction in the densities of the sandfly vectors). Unfortunately, the medium-term evaluation, conducted 5 months after spraying, was probably made invalid by flooding or lime plastering in the study areas. Preparation for, and the monitoring of, the IRS operations against sandfly populations in India and Nepal need to be improved.
Assuntos
Controle de Insetos/métodos , Resistência a Inseticidas , Inseticidas/toxicidade , Leishmaniose Visceral/prevenção & controle , Animais , Humanos , Índia/epidemiologia , Controle de Insetos/normas , Leishmaniose Visceral/epidemiologia , Nepal/epidemiologia , Avaliação de Programas e Projetos de Saúde , Psychodidae/efeitos dos fármacos , Inquéritos e QuestionáriosRESUMO
OBJECTIVES: To test the non-inferiority hypothesis that a vector control approach targeting only the most productive water container types gives the same or greater reduction of the vector population as a non-targeted approach in different ecological settings and to analyse whether the targeted intervention is less costly. METHODS: Cluster randomized trial in eight study sites (Venezuela, Mexico, Peru, Kenya, Thailand, Myanmar, Vietnam, Philippines), with each study area divided into 18-20 clusters (sectors or neighbourhoods) of approximately 50-100 households each. Using a baseline pupal-demographic survey, the most productive container types were identified which produced >or=55% of all Ae. aegypti pupae. Clusters were then paired based on similar pupae per person indices. One cluster from each pair was randomly allocated to receive the targeted vector control intervention; the other received the 'blanket' (non-targeted) intervention attempting to reach all water holding containers. RESULTS: The pupal-demographic baseline survey showed a large variation of productive container types across all study sites. In four sites the vector control interventions in both study arms were insecticidal and in the other four sites, non-insecticidal (environmental management and/or biological control methods). Both approaches were associated with a reduction of outcome indicators in the targeted and non-targeted intervention arm of the six study sites where the follow up study was conducted (PPI, Pupae per Person Index and BI, Breteau Index). Targeted interventions were as effective as non-targeted ones in terms of PPI. The direct costs per house reached were lower in targeted intervention clusters than in non-targeted intervention clusters with only one exception, where the targeted intervention was delivered through staff-intensive social mobilization. CONCLUSIONS: Targeting only the most productive water container types (roughly half of all water holding container types) was as effective in lowering entomological indices as targeting all water holding containers at lower implementation costs. Further research is required to establish the most efficacious method or combination of methods for targeted dengue vector interventions.
Assuntos
Dengue/prevenção & controle , Reservatórios de Doenças/parasitologia , Controle de Mosquitos/métodos , Água/parasitologia , Animais , Análise por Conglomerados , Dengue/epidemiologia , Dengue/transmissão , Humanos , Controle de Mosquitos/economia , Pupa , Abastecimento de ÁguaRESUMO
Data on the burden of visceral leishmaniasis (VL) in Indian sub-continent are vital for elimination programme planners for estimating resource requirements, effective implementation and monitoring of elimination programme. In Indian sub-continent, about 200 million population is at risk of VL. Nearly 25,000-40,000 cases and 200-300 deaths are reported every year, but these are grossly underestimates. Recent well-designed multicentric studies identified VL burden of 21 cases/10,000 among sampled population in Indian sub-continent (Bangladesh, India and Nepal). This estimates 4,20,000 cases per 200 million risk population clearly indicating that the disease is highly under-reported. Chemical and environmental vector control studies show that the indoor residual spraying (IRS) and long-lasting insecticidal nets (LLINs) are effective and significantly reduce sandfly densities. The findings documented from different sources revealed that some gaps and weakness in existing policies for introducing VL vector control interventions. Our studies emphasize the need of integrated vector management with both IRS and LLIN vector control interventions. Active case detection with rK39 strip test as diagnostic tool is the key element for detection of VL cases. The use of oral drug miltefosine for the treatment after assessing feasibility at community level is important. Kala-azar elimination in Indian sub-continent is possible if elimination programmes ensure access to health care and prevention of kala-azar for people at risk with particular attention to the poorest and marginalized groups. The evidence-based policy should be designed that motivates to implement the programmes, which will be cost-effective. Maintaining the acceptable level of incidence requires public awareness, vector control, appropriate diagnosis and treatment. The five pillars of VL elimination strategies identified are: early diagnosis and complete treatment; integrated vector management and vector surveillance; effective disease surveillance through passive and active case detection; social mobilization and building partnerships; and clinical and operational research which need to be re-enforced to effective implementation.
Assuntos
Controle de Insetos , Insetos Vetores/parasitologia , Leishmaniose Visceral/epidemiologia , Leishmaniose Visceral/prevenção & controle , Serviços Preventivos de Saúde , Psychodidae/parasitologia , Animais , Ásia/epidemiologia , Efeitos Psicossociais da Doença , Humanos , Saúde Pública , Fatores de Risco , Vigilância de Evento SentinelaRESUMO
Owing to increased epidemic activity and difficulties in controlling the insect vector, dengue has become a major public health problem in many parts of the tropics. The objective of this review is to analyse evidence regarding the achievements of community-based dengue control programmes. Medline, EMBASE, WHOLIS and the Cochrane Database of Systematic Reviews were searched (all to March 2005) to identify potentially relevant articles using keywords such as 'Aedes', 'dengue', 'breeding habits', 'housing' and 'community intervention'. According to the evaluation criteria recommended by the Cochrane Effective Practice and Organisation of Care Review Group, only studies that met the inclusion criteria of randomised controlled trials (RCT), controlled clinical trials (CCT), controlled before and after trials (CBA) or interrupted time series (ITS) were included. Eleven of 1091 studies met the inclusion criteria. Of these, two were RCTs, six were CBAs and three were ITS. The selected studies varied widely with respect to target groups, intervention procedures and outcome measurements. Six studies combined community participation programmes with dengue control tools. Methodological weaknesses were found in all studies: only two papers reported confidence intervals (95% CI); five studies reported P-values; two studies recognised the importance of water container productivity as a measure for vector density; in no study was cluster randomisation attempted; and in no study were costs and sustainability assessed. Evidence that community-based dengue control programmes alone and in combination with other control activities can enhance the effectiveness of dengue control programmes is weak.
Assuntos
Serviços de Saúde Comunitária/organização & administração , Dengue/prevenção & controle , Dengue/transmissão , Medicina Baseada em Evidências , Humanos , Controle de Insetos/métodos , Avaliação de Programas e Projetos de Saúde , Projetos de PesquisaRESUMO
Health interview surveys are carried out to gain knowledge of people's perceived morbidity, their use of different kinds of health services, and their perceived need for health care. Many of such studies in less developed countries (LDCs) have failed to consider the methodological improvements which have been developed in health care research in recent years. In the first part of this paper the research on methodological issues is summarized and the inherent problems in health interview surveys are stressed. Some specific requirements for cross-cultural research are described. The second part deals with health interview surveys carried out on a national, provincial and local level in LDCs. Recommendations for a standardization of the methodology are given.
Assuntos
Países em Desenvolvimento , Inquéritos Epidemiológicos , Entrevistas como Assunto/métodos , Comunicação , Comparação Transcultural , Humanos , Estudos Longitudinais , MorbidadeRESUMO
Between 1991 and 1994, an intervention program with permethrin- and lambdacyhalothrin-impregnated bed nets was carried out over a period of nine months in each of five endemic, malarious areas of Ecuador, Peru, and Colombia. This program was evaluated through household surveys, blood sampling, in-depth longitudinal studies, and entomologic analysis. Eighty-four communities (including approximately 35,000 individuals) were paired according to malaria incidence, size, and coverage with bed nets and then randomly allocated to intervention and control groups. The results showed that peoples' acceptance of the measure was related to their perception of an immediate protective effect against insects. The effectiveness of the bed nets, measured as a reduction of malaria incidence in intervention communities as against control communities, showed large variations between and within the study areas. The protective efficacy varied between 0% and 70% when looking only at the postintervention differences between intervention and control groups. The average protection was 40.8% when considering a four-month incidence of clinical malaria attacks and 28.3% when considering a two-week malaria incidence. Important factors for the success of the bed net program were insect susceptibility to pyrethroids, high coverage with impregnated bed nets, high malaria incidence, good community participation, high mosquito densities when people go to bed, and a high proportion of Plasmodium falciparum. In one area, where DDT spraying in the control communities was executed, the effectiveness of bed net impregnation was slightly better than that of spraying.
Assuntos
Anopheles , Mordeduras e Picadas de Insetos/prevenção & controle , Inseticidas , Malária/prevenção & controle , Controle de Mosquitos/métodos , Adolescente , Adulto , Fatores Etários , Animais , Roupas de Cama, Mesa e Banho , Criança , Pré-Escolar , Colômbia/epidemiologia , Equador/epidemiologia , Feminino , Humanos , Incidência , Malária/epidemiologia , Masculino , Nitrilas , Permetrina , Peru/epidemiologia , PiretrinasRESUMO
A study about the acceptability, protective efficacy, effectiveness, and cost of a repellent soap containing 20% diethyltoluamide and 0.5% permethrin was carried out on the Pacific coast of Ecuador and Peru, where malaria is endemic and the transmission is seasonal. The malaria vectors were Anopheles albimanus, An. punctimacula, and An. pseudopunctipennis in Ecuador and An. albimanus in Peru. Comparing the hourly mosquito bites on human subjects with and without the protection of the repellent soap, it showed that inactive, protected subjects were bitten 94.2% less than unprotected controls 2 hr after application of the soap. This protective efficacy was reduced to 81% after 6 hr. In persons physically active for 3 hr after application, the efficacy of the soap was 67% in the fourth hour after application and 52% in the sixth hour after application. Sweating decreased the protective efficacy of the soap even more. In a community-based malaria control program, the soap was introduced by community health promoters. Acceptance was good when it was given free of charge but reduced dramatically when it was sold. People used the soap mainly because of the nuisance of mosquitoes. The application was generally done correctly. However, no significant impact on the incidence of malaria episodes could be shown when comparing intervention communities with control communities, either in Ecuador, where the proportion of Plasmodium falciparum cases was high, or in Peru, where P. vivax was the only species of Plasmodium seen. This can probably be explained by the limited use of soap and the shift of mosquito bites from users to nonusers of the repellent soap. The cost of a soap program would be $4.60 (USA) per person per year, which seems to be quite high in terms of cost of soap and its distribution related to people's low cash income. The implications of the introduction of repellent soap into a control program are discussed.
Assuntos
Anopheles , Repelentes de Insetos/farmacologia , Malária/prevenção & controle , Sabões , Animais , Custos e Análise de Custo , Humanos , Insetos VetoresRESUMO
A double-blind, randomized trial was undertaken in Guatemala to determine the therapeutic efficacy of an ointment for the treatment of cutaneous leishmaniasis that contained 15% paromomycin and 12% methylbenzethonium chloride and that was applied twice a day for 20 days. The treatment group included 35 patients, and the placebo group included 33 patients. The initial clinical response rate (13 weeks after completing the treatment) was 91.4% in the treatment group and 39.4% in the placebo group. The final clinical response rate at the 12-month follow-up examination was 85.7% (31 of 35) in the treatment group and 39.4% (13 of 33) in the placebo group (P < or = 0.001). In general, the treatment was well tolerated and was never interrupted because of adverse effects. The number of adverse effects reported in the placebo group was lower than in the treatment group (16 events versus 30 events). All adverse effects reported by patients disappeared within 1 week of completing the treatment. Our findings show that the combination of paromomycin with methylbenzethonium chloride for 20 days is a good alternative for antimonial treatments of cutaneous leishmaniasis in Guatemala.
Assuntos
Antiprotozoários/administração & dosagem , Benzetônio/análogos & derivados , Benzetônio/administração & dosagem , Leishmaniose Cutânea/tratamento farmacológico , Paromomicina/administração & dosagem , Adolescente , Adulto , Benzetônio/efeitos adversos , Criança , Método Duplo-Cego , Quimioterapia Combinada , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pomadas , Paromomicina/efeitos adversosRESUMO
Fifty-two patients with American cutaneous leishmaniasis (ACL) from the Pacific coast of Ecuador were treated topically with an ointment containing 15% paramomycin (PR) and 12% methylbenzethonium chloride (MBCL) in vaselinum album (white soft paraffin; white petrolatum). After 20 applications (over 10 or 20 d) all lesions showed complete epithelialization within the first 100 d. Five patients developed new lesions during the one year observation period; 2 of these were probably reinfections. Considering all 5 cases as treatment failures, the healing rates were: 72% after 50 d, 90% after 100 d, and 85% after 360 d. In a separate study in the same area, a group of 23 patients was left without treatment for 3 months. Only 9% of the untreated patients healed spontaneously after 50 d. Growth of the lesion, inflammation and pain were observed at the beginning of treatment. After treatment, most lesions healed rapidly without scars. The drug was well accepted by the patients and was easy to administer under tropical field conditions.
Assuntos
Antiprotozoários/administração & dosagem , Benzetônio/análogos & derivados , Leishmaniose Cutânea/tratamento farmacológico , Paromomicina/administração & dosagem , Administração Cutânea , Adolescente , Adulto , Idoso , Benzetônio/administração & dosagem , Criança , Pré-Escolar , Combinação de Medicamentos , Humanos , Lactente , Leishmaniose Cutânea/patologia , Pessoa de Meia-Idade , Pomadas , Pele/patologiaRESUMO
Studies on the protective efficacy of insecticide-treated materials (ITMs) in Plasmodium vivax endemic areas of Latin America have not yielded sufficient evidence for recommendation of their extensive use in the region. Therefore 2 randomized community trials have been conducted on the Pacific Coast of Nicaragua which analysed the minimum coverage of ITMs needed to be effective against malaria. For the characterization of the study area, epidemiological and entomological baseline surveys and household interview surveys were undertaken. Thereafter the communities were paired (6 pairs in the 1st year and 13 pairs in the 2nd year) according to 4-monthly reported malaria incidence rates, population size and bednet coverage, and then randomly allocated to intervention and control groups. In the intervention groups, bednets were impregnated with lambdacyhalothrin; in the control groups, people received general health education. Anopheles albimanus was found to be the main vector with marked indoor biting behaviour late in the evening. P. vivax (99%) clearly outweighed P. falciparum (1%) with low parasite prevalence rates in the asymptomatic general population (8%) and low parasite densities. The protective efficacy of ITMs varied according to the coverage achieved: protective efficacy was 68% in communities with an average ITM coverage of 50% (10 pairs); 31% in communities with an ITM coverage of 16-30% (4 pairs); and no protective efficacy in communities with ITM coverage below 16% (5 pairs). The comparison with other P. vivax endemic areas in Latin America showed that the vector's late biting behaviour and the indoor preference (where ITMs have a repellent effect) probably led to the favourable results in the study. In malaria endemic areas of Latin America, where P. vivax is predominant, studies on vector behaviour should be conducted in order to predict the impact of ITMs on malaria transmission.
Assuntos
Inseticidas/administração & dosagem , Malária Vivax/prevenção & controle , Controle de Mosquitos/métodos , Adolescente , Animais , Anopheles/parasitologia , Roupas de Cama, Mesa e Banho , Criança , Pré-Escolar , Análise Custo-Benefício , Estudos Transversais , Feminino , Humanos , Incidência , Lactente , Insetos Vetores/parasitologia , Inseticidas/economia , Malária Vivax/economia , Malária Vivax/epidemiologia , Masculino , Controle de Mosquitos/economia , Nicarágua/epidemiologia , Plasmodium vivax/isolamento & purificaçãoRESUMO
For how long does the insecticidal effect of long-lasting nets achieve high Anopheles mortality? Four PermaNets tested previously in Colombia for wash resistance were bioassayed again after 3 years of use and 23 washes. The tests were done both in Colombia and a reference laboratory in Indonesia. Additionally the residual concentration of deltamethrin on the nets was chemically analysed. The results showed high Anopheles mortality and a mean deltamethrin concentration of 9.6 mg/m2. Discrepancies with other studies are discussed.
Assuntos
Anopheles , Inseticidas/análise , Controle de Mosquitos/métodos , Roupa de Proteção , Piretrinas/análise , Animais , Roupas de Cama, Mesa e Banho , Bioensaio , Colômbia , Feminino , Humanos , Inseticidas/administração & dosagem , Lavanderia , Controle de Mosquitos/normas , Nitrilas , Piretrinas/administração & dosagem , Taxa de SobrevidaRESUMO
Before recommending the skin-test use at national level in Guatemala of an antigen prepared from Leishmania major (a Leishmania species not found in the New World), we conducted a study in 100 Guatemalans to determine its sensitivity and specificity. The antigen consisted of 0.1 mL of a solution that contained 5 x 10(6) promastigotes of L. major (MRHO/IR/75/VAX). Positive leishmanin skin test (LST) reactions at 48 h were observed in 16 (80%) of 20 patients with proven active cutaneous leishmaniasis (CL), 18 (90%) of 20 with previously treated proven CL, and in 18 (90%) of 20 with a history and compatible scan of previously suspected but unconfirmed CL. None of 20 healthy controls or 20 patients with skin lesions due to causes other than CL had positive reactions to the LST, giving a sensitivity of 85% and specificity of 100%. There were no statistically significant differences in ethnic group, age, duration of the lesion, lesion size or Leishmania species between the 34 persons with true positive reactions. Even though it will be necessary to test this antigen on a larger number of patients, these preliminary results show that this antigen is specific and reasonably sensitive in identifying current or past CL and that it is a reasonable choice for epidemiological studies on CL in Guatemala.
Assuntos
Antígenos de Protozoários/imunologia , Leishmania major/imunologia , Leishmaniose Cutânea/diagnóstico , Testes Cutâneos/métodos , Adolescente , Adulto , Idoso , Animais , Guatemala/epidemiologia , Humanos , Leishmaniose Cutânea/epidemiologia , Pessoa de Meia-Idade , Sensibilidade e EspecificidadeRESUMO
An exploratory study assessing the economic consequences of inadequate prescribing by health-care providers was carried out in two cities of Chiapas State, South Mexico. Two research methods were used: (a) an exit survey with pharmacy users (1190 interviews) and (b) in-depth individual interviews with patients at hospital level (19 interviews). For comparative purposes, three tracer conditions were selected: acute respiratory infection (ARI), diarrhoeal disease (DD) and hypertension. The main findings were that doctors, drug vendors at pharmacies, traditional healers, users of health-care services themselves (through self-prescription) and other health staff are all sources of inadequate prescribing and impose a substantial economic burden of unnecessary cost on health-care users. In general, treatment costs were high compared with standard treatments, and prescriptions included a high proportion of non-essential drugs (50-64%). Additional costs to the standard treatment were particularly high when the prescription was by a medical doctor (US$ 3.57 per ARI prescription and US$ 8.37 for DD). Losses attributable to inadequate prescribing averaged US$ 47 per patient. The study concludes that training programmes on rational drug use aimed exclusively at medical doctors can only have a limited effect in reducing economic losses due to inadequate prescribing. Such efforts should be extended to other providers who are very active in prescribing drugs and providing health advice. The main challenge that the Mexican health system will be facing in the foreseeable future is not only to improve equity of access to essential drugs, but also to improve quality of drug advice and prescription and rational use of drugs by the population.
Assuntos
Farmacoeconomia , Pessoal de Saúde , Medicina Tradicional , Preparações Farmacêuticas/economia , Adulto , Coleta de Dados , Feminino , Humanos , Masculino , México , Pobreza , Saúde da População RuralRESUMO
A study on the efficacy of Bti spraying in mosquito breeding places was undertaken in the Pacific coast of Peru and Ecuador and in the Amazon area of Peru. It was shown that Bti is a powerful larvicide for Anopheles larvae, although it sinks quickly, whereas Anopheles larvae feed at the water surface. The duration of its effect was less than 7 days with the exception of the Amazon area of Peru, where it was approximately 10 days. In two study areas, Bti was sprayed weekly over periods of 10 and 7 weeks, respectively, and the adult mosquito densities were monitored. The Anopheles adult density (bites per person per hour on human baits) was reduced by an average of 70% in one area and by up to 50% in the other. This means that Bti spraying can potentially be an important component of a modified malaria control strategy.
Assuntos
Anopheles , Bacillus thuringiensis , Insetos Vetores , Malária/prevenção & controle , Controle Biológico de Vetores , Animais , Equador , Humanos , Larva , Peru , Densidade Demográfica , Fatores de TempoRESUMO
A household interview survey combined with a serological survey on the incidence of malaria attacks and prevalence of antibodies has been carried out in rural and urban areas of the pacific coast of Colombia. Additional information on people's knowledge, attitudes and behaviour towards malaria was collected by means of participant observation and informal interviews. The results show that people incorporate modern and traditional elements into their concepts of the disease and treatment strategies. The deficiencies of the official control programmes are shown from the people's point of view. Some human factors which influence malaria transmission are discussed and an estimate of the accuracy of self-diagnosis presented.
Assuntos
Controle de Doenças Transmissíveis/métodos , Conhecimentos, Atitudes e Prática em Saúde , Malária/prevenção & controle , Autocuidado/métodos , Colômbia/epidemiologia , Humanos , Incidência , Malária/epidemiologia , Malária/imunologia , Prevalência , População Rural , Autocuidado/psicologia , Estudos Soroepidemiológicos , Inquéritos e Questionários , População UrbanaRESUMO
A seminar with primary health care workers from four Indian groups in Ecuador serves as an example for the participatory evaluation of primary health care (PHC) programmes. Discussions in small groups, interpretation of visual aids, derived from research data on health care utilization, and practical evaluation exercises helped participants understand the opportunities and limitations which exist in the PHC schemes. The main topics of discussion were: health impacts of sociocultural change, community support of health workers, links with the hierarchy of the health care system, differential use of traditional and modern medicine and planning of future programmes. The final discussion with health officials was important for the mutual respect and understanding. The need for the involvement of communities and PHC workers in the evaluation of their own programmes is stressed.
PIP: The experience of a seminar of health care workers from 4 Indian groups in Ecuador is presented as an example of participatory evaluaton of primary health care programs. This approach has the advantage of drawing on the knowledge and judgments of the staff directly involved in primary health care at the local level and is nonthreatening since no quantitative measurements are taken. In this experiment, a survey on the differential use of health care by the 4 Indian populations was carried out collaboratively with the workers and the population. Participants in the seminar where the study was evaluated included indigenous health workers, representaties of Indian organizations, mestizo health workers, health officials from the national and provincial levels, and rural doctors. The main objectives of the seminar were to: establish or strengthen communication between health workers of the 4 indigenous groups and between medical and paraprofessional personnel, communicate research data from the health care utilization study, compare the different forms of primary health care, evaluate the basic health programs in indigenous and nonindigenous communities, and use the evaluation for a reorganization of local health plans. The most effective form of communication was discussions in small groups of about 8 people followed by panel discussions with all 60 participants. Topics of discussion included health impacts of sociocultural change, community support of health workers, links with the hierarchy of the health care system, and differential use of traditional and modern medicine. Supervision was seen as essential in the link between basic and higher health care levels. An immediate effect of the seminar was the successful petition for 2 Indian health posts in the underserved highland areas and a special meeting to be held between Indian representatives and health officials in the province of Morona Santiago. However, it is unclear whether dialog between primary health workers and health administrations will continue without further seminars. This experience suggests that participatory evaluatin should be included in health programs as a basic tool.