Detalhe da pesquisa
1.
Autism Spectrum Disorder- and/or Intellectual Disability-Associated Semaphorin-5A Exploits the Mechanism by Which Dock5 Signalosome Molecules Control Cell Shape.
Curr Issues Mol Biol
; 46(4): 3092-3107, 2024 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38666924
2.
Structural basis for the dual GTPase specificity of the DOCK10 guanine nucleotide exchange factor.
Biochem Biophys Res Commun
; 653: 12-20, 2023 04 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36848820
3.
Structural Insight into TNIK Inhibition.
Int J Mol Sci
; 23(21)2022 Oct 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-36361804
4.
Phosphorylated and non-phosphorylated HCK kinase domains produced by cell-free protein expression.
Protein Expr Purif
; 150: 92-99, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29793032
5.
A redox switch shapes the Lon protease exit pore to facultatively regulate proteolysis.
Nat Chem Biol
; 11(1): 46-51, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25383757
6.
Identification of pyrrolo[2,3-d]pyrimidines as potent HCK and FLT3-ITD dual inhibitors.
Bioorg Med Chem Lett
; 27(22): 4994-4998, 2017 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29037944
7.
Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen.
Bioorg Med Chem
; 25(16): 4259-4264, 2017 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28662963
8.
Lysosome-associated membrane proteins-1 and -2 (LAMP-1 and LAMP-2) assemble via distinct modes.
Biochem Biophys Res Commun
; 479(3): 489-495, 2016 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-27663661
9.
Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms.
Proc Natl Acad Sci U S A
; 109(9): 3305-10, 2012 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-22331897
10.
DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses.
Blood
; 119(19): 4451-61, 2012 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-22461490
11.
Immune regulatory functions of DOCK family proteins in health and disease.
Exp Cell Res
; 319(15): 2343-9, 2013 Sep 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-23911989
12.
A macrocyclic kinase inhibitor overcomes triple resistant mutations in EGFR-positive lung cancer.
NPJ Precis Oncol
; 8(1): 46, 2024 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38396251
13.
RhoG-Binding Domain of Elmo1 Ameliorates Excessive Process Elongation Induced by Autism Spectrum Disorder-Associated Sema5A.
Pathophysiology
; 30(4): 548-566, 2023 Nov 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38133141
14.
Targeting Ras-binding domain of ELMO1 by computational nanobody design.
Commun Biol
; 6(1): 284, 2023 03 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36932164
15.
A small molecule iCDM-34 identified by in silico screening suppresses HBV DNA through activation of aryl hydrocarbon receptor.
Cell Death Discov
; 9(1): 467, 2023 Dec 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38135680
16.
Cell-permeable carboxyl-terminal p27(Kip1) peptide exhibits anti-tumor activity by inhibiting Pim-1 kinase.
J Biol Chem
; 286(4): 2681-8, 2011 Jan 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-21062737
17.
Identification of critical residues in G(alpha)13 for stimulation of p115RhoGEF activity and the structure of the G(alpha)13-p115RhoGEF regulator of G protein signaling homology (RH) domain complex.
J Biol Chem
; 286(23): 20625-36, 2011 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-21507947
18.
Crystal structure of the Ca²âº/calmodulin-dependent protein kinase kinase in complex with the inhibitor STO-609.
J Biol Chem
; 286(25): 22570-9, 2011 Jun 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-21504895
19.
Identification of novel drug-resistant EGFR mutant inhibitors by in silico screening using comprehensive assessments of protein structures.
Bioorg Med Chem
; 20(12): 3756-67, 2012 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22607878
20.
Crystal structure of human acetylcholinesterase in complex with tacrine: Implications for drug discovery.
Int J Biol Macromol
; 210: 172-181, 2022 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35526766