Detalhe da pesquisa
1.
Correction: Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.
PLoS Biol
; 20(5): e3001621, 2022 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-35507910
2.
Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.
PLoS Biol
; 19(12): e3001480, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34914695
3.
Genetic modifiers of risk and age at onset in GBA associated Parkinson's disease and Lewy body dementia.
Brain
; 143(1): 234-248, 2020 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31755958
4.
Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis.
Neurobiol Dis
; 141: 104948, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32434048
5.
LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network.
Hum Mol Genet
; 27(2): 385-395, 2018 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29177506
6.
Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice.
Hum Mol Genet
; 27(18): 3257-3271, 2018 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29917075
7.
Differences in Stability, Activity and Mutation Effects Between Human and Mouse Leucine-Rich Repeat Kinase 2.
Neurochem Res
; 44(6): 1446-1459, 2019 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-30291536
8.
The G2385R risk factor for Parkinson's disease enhances CHIP-dependent intracellular degradation of LRRK2.
Biochem J
; 474(9): 1547-1558, 2017 04 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28320779
9.
Pathways to Parkinsonism Redux: convergent pathobiological mechanisms in genetics of Parkinson's disease.
Hum Mol Genet
; 24(R1): R32-44, 2015 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26101198
10.
Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease.
Proc Natl Acad Sci U S A
; 111(7): 2626-31, 2014 Feb 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-24510904
11.
Development and characterization of phospho-ubiquitin antibodies to monitor PINK1-PRKN signaling in cells and tissue.
bioRxiv
; 2024 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38293125
12.
Association of Variants in the SPTLC1 Gene With Juvenile Amyotrophic Lateral Sclerosis.
JAMA Neurol
; 78(10): 1236-1248, 2021 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34459874
13.
LRRK2 mediates tubulation and vesicle sorting from lysosomes.
Sci Adv
; 6(46)2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33177079
14.
The Parkinson's Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network.
Cell Rep
; 31(5): 107614, 2020 05 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32375042
15.
LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies.
Sci Transl Med
; 12(565)2020 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33055242
16.
Differential DJ-1 gene expression in Parkinson's disease.
Neurobiol Dis
; 36(2): 393-400, 2009 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-19716892
17.
TDP-43 in ubiquitinated inclusions in the inferior olives in frontotemporal lobar degeneration and in other neurodegenerative diseases: a degenerative process distinct from normal ageing.
Acta Neuropathol
; 118(3): 359-69, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19330339
18.
Post-transcriptional regulation of mRNA associated with DJ-1 in sporadic Parkinson disease.
Neurosci Lett
; 452(1): 8-11, 2009 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-19146923
19.
The DYT6 Dystonia Protein THAP1 Regulates Myelination within the Oligodendrocyte Lineage.
Dev Cell
; 42(1): 52-67.e4, 2017 07 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28697333
20.
Hexokinases link DJ-1 to the PINK1/parkin pathway.
Mol Neurodegener
; 12(1): 70, 2017 09 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-28962651