RESUMO
Suspensions of superparamagnetic colloids that equilibrate in a toggled magnetic field undergo a Rayleigh-Plateau instability with a characteristic wavelength λ = 600 µm for the toggle frequency ν = 0.66 Hz. The instability is suppressed when the chamber length L in the field direction is less than 2λ. The final size of the magnetic domains perpendicular to the field, D, follows a power law relation of D â¼ L(0.71±0.07). These results demonstrate the structural differences of field-directed suspensions when confined to lengths scale set by the phase separation process and can potentially be used to create self-assembled colloidal crystals with well-defined size and shape.
RESUMO
Suspensions of paramagnetic colloids are driven to phase separate and self-assemble in toggled magnetic fields. At field strengths above 575 A/m and toggle frequencies between 0.66 and 2 Hz, an initial gel-like, arrested network collapses into condensed, ellipsoidal aggregates. The evolution to this equilibrium structure occurs via a Rayleigh-Plateau instability. The toggle frequency ν determines the fluidity of the breakup process. At frequencies between 0.66 and 1.5 Hz, the suspension breaks up similar to a viscous, Newtonian fluid. At frequencies ν > 1.5 Hz, the network ruptures like a viscoplastic material. The field strength alters the onset time of the instability. A power law relationship emerges as the scaled frequency and field strength can be used to predict the onset of breakup. These results further aid in understanding the mechanics and dynamics of the phase separation process of suspensions of polarizable colloids in toggled external fields.
RESUMO
Martin J. Kurian, Peter J. Rentzepis, Ann M. Carracher, and Kelly L. Close are of Close Concerns (http://www.closeconcerns.com), a healthcare information company focused exclusively on diabetes and obesity care. Close Concerns publishes Closer Look, a periodical that brings together news and insights in these areas. Each month, the Journal of Diabetes includes this News feature, in which Kurian, Rentzepis, Carracher, and Close review the latest developments relevant to researchers and clinicians.
Assuntos
Atenção à Saúde , Diabetes Mellitus Tipo 2/prevenção & controle , Obesidade/fisiopatologia , Diabetes Mellitus Tipo 2/epidemiologia , Humanos , Sociedades MédicasRESUMO
Martin J. Kurian, Peter J. Rentzepis, Ann M. Carracher, and Kelly L. Close are of Close Concerns (http://www.closeconcerns.com), a healthcare information company focused exclusively on diabetes and obesity care. Close Concerns publishes Closer Look, a periodical that brings together news and insights in these areas. Each month, the Journal of Diabetes includes this News feature, in which Kurian, Rentzepis, Carracher, and Close review the latest developments relevant to researchers and clinicians.
Assuntos
Cardiologia , Sociedades Médicas , Doenças Cardiovasculares/diagnóstico , Diabetes Mellitus Tipo 2/tratamento farmacológico , Europa (Continente) , Receptor do Peptídeo Semelhante ao Glucagon 1/agonistas , Peptídeos Semelhantes ao Glucagon/uso terapêutico , Humanos , Inibidores do Transportador 2 de Sódio-Glicose/uso terapêuticoRESUMO
Martin J. Kurian, Peter J. Rentzepis, Ann M. Carracher, and Kelly L. Close are of Close Concerns (http://www.closeconcerns.com), a healthcare information company focused exclusively on diabetes and obesity care. Close Concerns publishes Closer Look, a periodical that brings together news and insights in these areas. Each month, the Journal of Diabetes includes this News feature, in which Kurian, Rentzepis, Carracher, and Close review the latest developments relevant to researchers and clinicians.
Assuntos
Doenças Cardiovasculares/prevenção & controle , Diabetes Mellitus Tipo 2/terapia , Doenças Cardiovasculares/diagnóstico , Doenças Cardiovasculares/etiologia , Atenção à Saúde , Diabetes Mellitus Tipo 2/complicações , Europa (Continente) , Humanos , Sociedades MédicasRESUMO
Ursula Biba, Rhea W. Teng, Martin J. Kurian, Ann M. Carracher, and Kelly L. Close are of Close Concerns (http://www.closeconcerns.com), a healthcare information company focused exclusively on diabetes and obesity care. Close Concerns publishes Closer Look, a periodical that brings together news and insights in these areas. Each month, the Journal of Diabetes includes this News feature, in which Biba, Teng, Kurian, Carracher, and Close review the latest developments relevant to researchers and clinicians.
Assuntos
Atenção à Saúde/normas , Diabetes Mellitus Tipo 2/tratamento farmacológico , Hipoglicemiantes/uso terapêutico , Diabetes Mellitus Tipo 2/diagnóstico , Humanos , Sociedades MédicasRESUMO
Martin J. Kurian, Peter J. Rentzepis, Ann M. Carracher, and Kelly L. Close are of Close Concerns (http://www.closeconcerns.com), a healthcare information company focused exclusively on diabetes and obesity care. Close Concerns publishes Closer Look, a periodical that brings together news and insights in these areas. Each month, the Journal of Diabetes includes this News feature, in which Kurian, Rentzepis, Carracher, and Close review the latest developments relevant to researchers and clinicians.
Assuntos
Atenção à Saúde/normas , Diabetes Mellitus Tipo 2/terapia , Diabetes Mellitus Tipo 2/diagnóstico , Humanos , Sociedades MédicasRESUMO
Martin J. Kurian, Peter J. Rentzepis, Ann M. Carracher, and Kelly L. Close are of Close Concerns (http://www.closeconcerns.com), a healthcare information company focused exclusively on diabetes and obesity care. Close Concerns publishes Closer Look, a periodical that brings together news and insights in these areas. Each month, the Journal of Diabetes includes this News feature, in which Kurian, Rentzepis, Carracher, and Close review the latest developments relevant to researchers and clinicians.
Assuntos
Atenção à Saúde/normas , Diabetes Mellitus/terapia , Hipertensão/terapia , Obesidade/terapia , Congressos como Assunto , Consenso , Gerenciamento Clínico , Humanos , Sociedades MédicasRESUMO
Martin J. Kurian, Peter J. Rentzepis, Ann M. Carracher, and Kelly L. Close are of Close Concerns (http://www.closeconcerns.com), a healthcare information company focused exclusively on diabetes and obesity care. Close Concerns publishes Closer Look, a periodical that brings together news and insights in these areas. Each month, the Journal of Diabetes includes this News feature, in which Kurian, Rentzepis, Carracher, and Close review the latest developments relevant to researchers and clinicians.
Assuntos
Determinação da Pressão Arterial/instrumentação , Pressão Sanguínea , Hipertensão/fisiopatologia , Telemedicina/métodos , Atenção à Saúde/economia , Atenção à Saúde/métodos , Diabetes Mellitus Tipo 2/sangue , Diabetes Mellitus Tipo 2/prevenção & controle , Diabetes Mellitus Tipo 2/terapia , Hemoglobinas Glicadas/metabolismo , Custos de Cuidados de Saúde , Humanos , Hipertensão/prevenção & controle , Telemedicina/economia , Telemedicina/tendênciasRESUMO
Martin J. Kurian, Peter J. Rentzepis, Ann M. Carracher, and Kelly L. Close are of Close Concerns (http://www.closeconcerns.com), a healthcare information company focused exclusively on diabetes and obesity care. Close Concerns publishes Closer Look, a periodical that brings together news and insights in these areas. Each month, the Journal of Diabetes includes this News feature, in which Kurian, Rentzepis, Carracher, and Close review the latest developments relevant to researchers and clinicians.
Assuntos
Doenças Cardiovasculares/prevenção & controle , Diabetes Mellitus Tipo 2/complicações , American Heart Association , Doenças Cardiovasculares/etiologia , Atenção à Saúde , Humanos , Sociedades Médicas , Estados UnidosRESUMO
Martin J. Kurian, Peter J. Rentzepis, Ann M. Carracher, and Kelly L. Close are of Close Concerns (http://www.closeconcerns.com), a healthcare information company focused exclusively on diabetes and obesity care. Close Concerns publishes Closer Look, a periodical that brings together news and insights in these areas. Each month, the Journal of Diabetes includes this News feature, in which Kurian, Rentzepis, Carracher, and Close review the latest developments relevant to researchers and clinicians.
Assuntos
Ensaios Clínicos como Assunto/normas , Atenção à Saúde/normas , Diabetes Mellitus Tipo 2/prevenção & controle , Congressos como Assunto , Gerenciamento Clínico , HumanosRESUMO
Ursula Biba, Rhea W. Teng, Martin J. Kurian, and Kelly L. Close are of Close Concerns (http://www.closeconcerns.com), a healthcare information company focused exclusively on diabetes and obesity care. Close Concerns publishes Closer Look, a periodical that brings together news and insights in these areas. Each month, the Journal of Diabetes includes this News feature, in which Biba, Teng, Kurian, and Close review the latest developments relevant to researchers and clinicians.
Assuntos
Atenção à Saúde/normas , Diabetes Mellitus Tipo 2/terapia , Congressos como Assunto , Gerenciamento Clínico , HumanosRESUMO
Sodium-glucose cotransporter (SGLT) inhibitors are new oral antidiabetes medications shown to effectively reduce glycated hemoglobin (A1C) and glycemic variability, blood pressure, and body weight without intrinsic properties to cause hypoglycemia in people with type 1 diabetes. However, recent studies, particularly in individuals with type 1 diabetes, have demonstrated increases in the absolute risk of diabetic ketoacidosis (DKA). Some cases presented with near-normal blood glucose levels or mild hyperglycemia, complicating the recognition/diagnosis of DKA and potentially delaying treatment. Several SGLT inhibitors are currently under review by the U.S. Food and Drug Administration and European regulatory agencies as adjuncts to insulin therapy in people with type 1 diabetes. Strategies must be developed and disseminated to the medical community to mitigate the associated DKA risk. This Consensus Report reviews current data regarding SGLT inhibitor use and provides recommendations to enhance the safety of SGLT inhibitors in people with type 1 diabetes.
Assuntos
Diabetes Mellitus Tipo 1 , Diabetes Mellitus Tipo 2 , Cetoacidose Diabética , Inibidores do Transportador 2 de Sódio-Glicose , Consenso , Glucose , Humanos , Hipoglicemiantes , Gestão de Riscos , SódioRESUMO
Martin J. Kurian, Ann M. Carracher, and Kelly L. Close are of Close Concerns (http://www.closeconcerns.com), a healthcare information company focused exclusively on diabetes and obesity care. Close Concerns publishes Closer Look, a periodical that brings together news and insights in these areas. Each month, the Journal of Diabetes includes this News feature, in which Kurian, Carracher, and Close review the latest developments relevant to researchers and clinicians.
Assuntos
Pesquisa Biomédica/métodos , Glicemia/efeitos dos fármacos , Diabetes Mellitus Tipo 1/tratamento farmacológico , Diabetes Mellitus Tipo 2/tratamento farmacológico , Hipoglicemiantes/uso terapêutico , Biomarcadores/sangue , Glicemia/metabolismo , Diabetes Mellitus Tipo 1/sangue , Diabetes Mellitus Tipo 1/diagnóstico , Diabetes Mellitus Tipo 2/sangue , Diabetes Mellitus Tipo 2/diagnóstico , Humanos , Hipoglicemiantes/efeitos adversos , Resultado do TratamentoRESUMO
Peter J. Rentzepis, Martin J. Kurian, Ann M. Carracher, and Kelly L. Close are of Close Concerns (http://www.closeconcerns.com), a healthcare information company focused exclusively on diabetes and obesity care. Close Concerns publishes Closer Look, a periodical that brings together news and insights in these areas. Each month, the Journal of Diabetes includes this News feature, in which Rentzepis, Kurian, Carracher, and Close review the latest developments relevant to researchers and clinicians.