Detalhe da pesquisa
1.
MEK drives BRAF activation through allosteric control of KSR proteins.
Nature
; 554(7693): 549-553, 2018 02 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29433126
2.
Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function.
Mol Cell
; 59(6): 970-83, 2015 Sep 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-26344097
3.
Structural and biochemical analysis of human ADP-ribosyl-acceptor hydrolase 3 reveals the basis of metal selectivity and different roles for the two magnesium ions.
J Biol Chem
; 296: 100692, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33894202
4.
Functional characterization of a PROTAC directed against BRAF mutant V600E.
Nat Chem Biol
; 16(11): 1170-1178, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32778845
5.
Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly.
Mol Cell
; 56(2): 246-260, 2014 Oct 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-25306923
6.
Structural basis for auxiliary subunit KCTD16 regulation of the GABAB receptor.
Proc Natl Acad Sci U S A
; 116(17): 8370-8379, 2019 04 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30971491
7.
Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids.
J Biol Chem
; 295(14): 4526-4540, 2020 04 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32086379
8.
Structure of human ADP-ribosyl-acceptor hydrolase 3 bound to ADP-ribose reveals a conformational switch that enables specific substrate recognition.
J Biol Chem
; 293(32): 12350-12359, 2018 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29907568
9.
Atg8 transfer from Atg7 to Atg3: a distinctive E1-E2 architecture and mechanism in the autophagy pathway.
Mol Cell
; 44(3): 451-61, 2011 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-22055190
10.
Regulation of Protein Interactions by Mps One Binder (MOB1) Phosphorylation.
Mol Cell Proteomics
; 16(6): 1111-1125, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28373297
11.
MOB1 Mediated Phospho-recognition in the Core Mammalian Hippo Pathway.
Mol Cell Proteomics
; 16(6): 1098-1110, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28373298
12.
Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1-F-box interface.
Proc Natl Acad Sci U S A
; 113(13): 3527-32, 2016 Mar 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-26976582
13.
Crystal structure of the human Polϵ B-subunit in complex with the C-terminal domain of the catalytic subunit.
J Biol Chem
; 292(38): 15717-15730, 2017 09 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28747437
14.
Structural and functional characterization of KEOPS dimerization by Pcc1 and its role in t6A biosynthesis.
Nucleic Acids Res
; 44(14): 6971-80, 2016 08 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-27302132
15.
Structural basis for the recruitment of glycogen synthase by glycogenin.
Proc Natl Acad Sci U S A
; 111(28): E2831-40, 2014 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24982189
16.
Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine.
Mol Cell
; 32(2): 259-75, 2008 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-18951093
17.
Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system.
Nucleic Acids Res
; 41(12): 6332-46, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23620299
18.
The CNK-HYP scaffolding complex promotes RAF activation by enhancing KSR-MEK interaction.
Nat Struct Mol Biol
; 2024 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38388830
19.
Structural and functional validation of a highly specific Smurf2 inhibitor.
Protein Sci
; 33(2): e4885, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38147466
20.
Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes.
Protein Sci
; 33(1): e4824, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37945533