RESUMO
A comparative study of bemithyl pharmacokinetics was carried out upon its inhalation, intragastric and intravenous administration. The main drug metabolites were identified and the pharmacokinetic parameters were calculated. The obtained results suggest that the inhalation administration of bemithyl is a promising replacement for oral administration, which is related to high bioavailability of the drug and the absence of the effect of "first pass" through the liver.
Assuntos
Anticonvulsivantes/farmacologia , Anticonvulsivantes/farmacocinética , Benzimidazóis/farmacologia , Benzimidazóis/farmacocinética , Fígado/metabolismo , Administração por Inalação , Animais , Masculino , RatosRESUMO
The effect of memantine administration has been studied on the model of mice poisoning with an anticholinesterase compound. It is established that the memantine action is due to its influence on the cholinesterase activity in the brain, blood plasma, and erythrocytes in addition to its NMDA-blocking action. Memantine promotes oxime-induced erythrocyte enzyme reactivation on the model of mice poisoning with anticholinesterase compound (0.8 LD50).
Assuntos
Anticonvulsivantes/farmacologia , Reativadores da Colinesterase/farmacologia , Memantina/farmacologia , Intoxicação por Organofosfatos/tratamento farmacológico , Acetilcolinesterase/metabolismo , Animais , Anticonvulsivantes/metabolismo , Encéfalo/efeitos dos fármacos , Encéfalo/enzimologia , Butirilcolinesterase/metabolismo , Inibidores da Colinesterase/intoxicação , Reativadores da Colinesterase/metabolismo , Eritrócitos/efeitos dos fármacos , Eritrócitos/enzimologia , Isoflurofato/intoxicação , Dose Letal Mediana , Masculino , Memantina/metabolismo , Camundongos , N-Metilaspartato/antagonistas & inibidores , N-Metilaspartato/metabolismo , Intoxicação por Organofosfatos/sangue , Oximas/metabolismoRESUMO
Combined administration of caffeine and ketorolac (NSAID) is accompanied by all possible types of drug interaction. Side effects of the drug combination are mostly due to the action of ketorolac and manifested by decompensated renal failure and progressive endotoxemia within 3 - 7 days after single administration of drugs. Thus, the amplification of ketorolac effects by caffeine must be taken into consideration in prescribing NSAIDs.