RESUMO
We describe a patient with extracutaneous pyoderma gangrenosum (PG), who presented with chest pain. Histological examination showed extracutaneous neutrophilic infiltration of the spleen and lung, with later findings of PG.
Assuntos
Pioderma Gangrenoso , Humanos , Pulmão/patologia , Pioderma Gangrenoso/patologia , Pele/patologia , Baço/patologia , Tórax/patologiaAssuntos
Antígeno B7-H1/antagonistas & inibidores , Carcinoma de Célula de Merkel , Infecções por Vírus Epstein-Barr , Neoplasias Cutâneas , Adulto , Carcinoma de Célula de Merkel/radioterapia , Infecções por Vírus Epstein-Barr/complicações , Infecções por Vírus Epstein-Barr/diagnóstico , Herpesvirus Humano 4 , Humanos , Masculino , Neoplasias Cutâneas/radioterapiaAssuntos
Anticorpos/análise , Carcinoma de Células Escamosas/diagnóstico , Doenças Musculares/diagnóstico , Idoso de 80 Anos ou mais , Anticorpos/sangue , Doenças Autoimunes/sangue , Doenças Autoimunes/diagnóstico , Carcinoma de Células Escamosas/sangue , Feminino , Humanos , Hidroximetilglutaril-CoA Redutases/análise , Hidroximetilglutaril-CoA Redutases/sangue , Doenças Musculares/sangueRESUMO
Pigmented Bowen's disease (pBD) is a subtype of Bowen's disease, which presents clinically as a well-circumscribed, hyperpigmented plaque. Its clinical manifestations are not fully characterized, and differential diagnoses include various pigmented skin lesions. Dermoscopy could be useful for the diagnosis, although nothing has been reported on the dermoscopic features of clonal-type pBD. We herein report a first case of clonal-type pBD on the sole and its dermoscopic features. Dermoscopy showed brown to blue-gray dots/globules and focally anastomosing lines on the non-weight-bearing area, while the weight-bearing area had a brown to blue-gray fibrillar-like pattern. To investigate the relationship between dermoscopy and histopathology, we focused on the melanin distribution in the horny layer of the epidermis, and used vertical dermoscopy observation. We investigated the relationship between dermoscopy and pathology by melanin depth estimation using a color lightness value.
Assuntos
Doença de Bowen/diagnóstico por imagem , Dermoscopia/métodos , Hiperpigmentação/diagnóstico por imagem , Neoplasias Cutâneas/diagnóstico por imagem , Adulto , Biópsia , Doença de Bowen/patologia , Diagnóstico Diferencial , Pé , Humanos , Hiperpigmentação/patologia , Masculino , Melaninas/análise , Pele/diagnóstico por imagem , Pele/patologia , Neoplasias Cutâneas/patologiaAssuntos
Carcinoma de Células Escamosas/complicações , Displasia Ectodérmica Anidrótica Tipo 1/complicações , Neoplasias de Cabeça e Pescoço/complicações , Ceratoacantoma/complicações , Neoplasias Cutâneas/complicações , Adulto , Carcinoma de Células Escamosas/patologia , Displasia Ectodérmica Anidrótica Tipo 1/patologia , Neoplasias de Cabeça e Pescoço/patologia , Humanos , Ceratoacantoma/patologia , Masculino , Neoplasias Cutâneas/patologiaAssuntos
Adenocarcinoma Sebáceo , Carcinoma de Célula de Merkel , Neoplasias Palpebrais , Neoplasias das Glândulas Sebáceas , Neoplasias Cutâneas , Adenocarcinoma Sebáceo/diagnóstico , Adenocarcinoma Sebáceo/cirurgia , Neoplasias Palpebrais/diagnóstico , Pálpebras , Humanos , Linfonodos , Metástase Linfática , Estudos Retrospectivos , Neoplasias das Glândulas Sebáceas/diagnósticoRESUMO
Primary cancer of the trachea is rare and accounts for only 0.1-0.4% of all newly diagnosed respiratory tract cancers, worldwide. In the present study, a case of primary tracheal malignant melanoma, a particularly rare type of cancer, is reported. A 68-year-old male presented with a cough and bloody sputum. A chest computed tomography scan revealed a 25×20×15-mm tracheal tumor, located immediately above the carina, which reduced the cross-sectional area of the trachea by ~90%. Histopathological analysis of biopsy specimens determined a diagnosis of malignant melanoma. The patient was treated with argon plasma coagulation and chemoradiotherapy, which restored airway patency, however, metastasis was detected in the lungs. The patient refused further treatment and received palliative care. Subsequently, the patient succumbed to the disease within four months. Thus, although primary malignant melanoma of the trachea is extremeley rare, the possibility should be considered during diagnosis.