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Gan To Kagaku Ryoho ; 42(7): 879-81, 2015 Jul.
Artigo em Japonês | MEDLINE | ID: mdl-26197755

RESUMO

A 53-year-old patient with recurrent ovarian clear cell adenocarcinoma developed fever (39°C) and cough on day 28 of liposomal doxorubicin chemotherapy, the 4th cycle of the 4th regimen since initial treatment. Drug-induced interstitial pneumonia was suspected from a chest CT image showing diffuse ground-glass opacities; however, we deduced pneumocystis pneumonia from the elevated serum beta-D-glucan levels. After effective treatment with sulfamethoxazole and amphotericin B, the patient's symptoms and radiological findings improved. Pneumocystis pneumonia is an opportunistic infection that poses a risk not only for patients undergoing aggressive immunosuppressive therapy, those infected with HIV, and those with transplants, but also for patients undergoing chemotherapy. When pneumonia is diagnosed during chemotherapy, it is essential to consider the possibility of pneumocystis pneumonia.


Assuntos
Adenocarcinoma de Células Claras/tratamento farmacológico , Antibióticos Antineoplásicos/efeitos adversos , Doxorrubicina/efeitos adversos , Neoplasias Ovarianas/tratamento farmacológico , Pneumonia por Pneumocystis/induzido quimicamente , Anfotericina B/uso terapêutico , Antibióticos Antineoplásicos/uso terapêutico , Doxorrubicina/uso terapêutico , Feminino , Humanos , Pessoa de Meia-Idade , Neoplasias Ovarianas/secundário , Pneumonia por Pneumocystis/tratamento farmacológico , Recidiva , Esteroides/uso terapêutico
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