Detalhe da pesquisa
1.
Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands.
Nat Chem Biol
; 14(4): 405-412, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29507391
2.
Development of CDK2 and CDK5 Dual Degrader TMX-2172.
Angew Chem Int Ed Engl
; 59(33): 13865-13870, 2020 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32415712
3.
A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification.
J Am Chem Soc
; 141(1): 191-203, 2019 01 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30518210
4.
Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease.
Proc Natl Acad Sci U S A
; 107(28): 12617-22, 2010 Jul 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-20616024
5.
Catalytic Degraders Effectively Address Kinase Site Mutations in EML4-ALK Oncogenic Fusions.
J Med Chem
; 66(8): 5524-5535, 2023 04 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37036171
6.
Human Polo-like Kinase Inhibitors as Antiplasmodials.
ACS Infect Dis
; 9(4): 1004-1021, 2023 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36919909
7.
Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias.
Nat Cancer
; 4(5): 754-773, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37237081
8.
A Novel HER2-Selective Kinase Inhibitor Is Effective in HER2 Mutant and Amplified Non-Small Cell Lung Cancer.
Cancer Res
; 82(8): 1633-1645, 2022 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35149586
9.
Novel Macrocyclic Peptidomimetics Targeting the Polo-Box Domain of Polo-Like Kinase 1.
J Med Chem
; 65(3): 1915-1932, 2022 02 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35029981
10.
Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling.
Elife
; 112022 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-36300789
11.
Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma.
Eur J Med Chem
; 221: 113481, 2021 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33945934
12.
Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins.
Cell Rep
; 34(1): 108532, 2021 01 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33406420
13.
Discovery of MFH290: A Potent and Highly Selective Covalent Inhibitor for Cyclin-Dependent Kinase 12/13.
J Med Chem
; 63(13): 6708-6726, 2020 07 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32502343
14.
Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors.
Cell Chem Biol
; 27(5): 525-537.e6, 2020 05 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32130941
15.
A kinase-independent role for CDK8 in BCR-ABL1+ leukemia.
Nat Commun
; 10(1): 4741, 2019 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-31628323
16.
Structural origin of selectivity in class II-selective histone deacetylase inhibitors.
J Med Chem
; 51(10): 2898-906, 2008 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-18412327
17.
Discovery of Immunologically Inspired Small Molecules That Target the Viral Envelope Protein.
ACS Infect Dis
; 4(9): 1395-1406, 2018 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30027735
18.
Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13.
Elife
; 72018 11 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30422115
19.
Correction to Discovery of Immunologically Inspired Small Molecules That Target the Viral Envelope Protein.
ACS Infect Dis
; 5(12): 2176, 2019 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31675213
20.
Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR.
Cancer Res
; 73(8): 2574-86, 2013 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23436801