1.
Infect Immun
; 74(8): 4954-9, 2006 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16861689
RESUMO
Tuberculosis subunit vaccines codelivered with interleukin-12 (IL-12)-encapsulated microspheres (IL-12EM) are designed for a sustained release of IL-12 and could induce strong Th1 immune responses specific to Ag85A and ESAT-6. The adjuvant combination of IL-12EM plus AS01B was a more efficient way to induce a sustained Th1 immunity and protection against Mycobacterium tuberculosis.