Detalhe da pesquisa
1.
In Vitro and In Vivo Mechanistic Studies toward Understanding the Role of 1-Aminobenzotriazole in Rat Drug-Drug Interactions.
Drug Metab Dispos
; 43(12): 1960-5, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26438628
2.
Design and synthesis of potent, isoxazole-containing renin inhibitors.
Bioorg Med Chem Lett
; 22(8): 2670-4, 2012 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22450130
3.
Applying the pro-drug approach to afford highly bioavailable antagonists of P2Y(14).
Bioorg Med Chem Lett
; 21(14): 4366-8, 2011 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21689930
4.
Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of spirocyclic piperidines.
Bioorg Med Chem Lett
; 21(24): 7399-404, 2011 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22071301
5.
Azaindoles as potent CRTH2 receptor antagonists.
Bioorg Med Chem Lett
; 21(2): 841-5, 2011 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21185722
6.
A novel series of potent and selective EP(4) receptor ligands: facile modulation of agonism and antagonism.
Bioorg Med Chem Lett
; 21(1): 484-7, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21126875
7.
New indole amide derivatives as potent CRTH2 receptor antagonists.
Bioorg Med Chem Lett
; 21(11): 3471-4, 2011 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21515053
8.
Impact of passive permeability and gut efflux transport on the oral bioavailability of novel series of piperidine-based renin inhibitors in rodents.
Bioorg Med Chem Lett
; 21(18): 5547-51, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21784634
9.
Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP4 receptor.
Bioorg Med Chem Lett
; 21(3): 1041-6, 2011 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21215624
10.
The discovery and synthesis of potent zwitterionic inhibitors of renin.
Bioorg Med Chem Lett
; 21(8): 2430-6, 2011 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21429746
11.
Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of tertiary alcohol-bearing piperidines.
Bioorg Med Chem Lett
; 21(13): 3976-81, 2011 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21641209
12.
Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of pyridone-substituted piperidines.
Bioorg Med Chem Lett
; 21(13): 3970-5, 2011 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21621998
13.
The identification of 4,7-disubstituted naphthoic acid derivatives as UDP-competitive antagonists of P2Y14.
Bioorg Med Chem Lett
; 21(10): 2836-9, 2011 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21507640
14.
Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases.
Bioorg Med Chem Lett
; 21(1): 288-93, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21106375
15.
Addressing time-dependent CYP 3A4 inhibition observed in a novel series of substituted amino propanamide renin inhibitors, a case study.
Bioorg Med Chem Lett
; 20(17): 5074-9, 2010 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20673718
16.
Discovery of 4-[1-[([1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl]carbonyl)amino]cyclopropyl]benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain.
Bioorg Med Chem Lett
; 20(12): 3760-3, 2010 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20471829
17.
Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment.
Bioorg Med Chem Lett
; 20(22): 6387-93, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20933411
18.
Design and optimization of a substituted amino propanamide series of renin inhibitors for the treatment of hypertension.
Bioorg Med Chem Lett
; 20(7): 2204-9, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20206513
19.
The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor.
Bioorg Med Chem Lett
; 20(3): 887-92, 2010 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20061146
20.
Alkyl-bridged substituted 8-arylquinolines as highly potent PDE IV inhibitors.
Bioorg Med Chem Lett
; 19(17): 5266-9, 2009 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19640717