Detalhe da pesquisa
1.
An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells.
Cell
; 182(4): 1009-1026.e29, 2020 08 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32730809
2.
Synthesis of portimines reveals the basis of their anti-cancer activity.
Nature
; 622(7983): 507-513, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-37730997
3.
Chemoproteomics reveals microbiota-derived aromatic monoamine agonists for GPRC5A.
Nat Chem Biol
; 19(10): 1205-1214, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37248411
4.
A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling.
Nature
; 562(7728): 600-604, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30323285
5.
Author Correction: Synthesis of portimines reveals the basis of their anti-cancer activity.
Nature
; 622(7984): E3, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-37798445
6.
A Cell Type Selective YM155 Prodrug Targets Receptor-Interacting Protein Kinase 2 to Induce Brain Cancer Cell Death.
J Am Chem Soc
; 2023 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37017374
7.
Optimization of 3-aminotetrahydrothiophene 1,1-dioxides with improved potency and efficacy as non-electrophilic antioxidant response element (ARE) activators.
Bioorg Med Chem Lett
; 89: 129306, 2023 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37116763
8.
A cell type-selective apoptosis-inducing small molecule for the treatment of brain cancer.
Proc Natl Acad Sci U S A
; 116(13): 6435-6440, 2019 03 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-30846550
9.
Towards an Understanding of the Molecular Mechanisms of Variable Unnatural Base-Pair Behavior: A Biophysical Analysis of dNaM-dTPT3.
Chemistry
; 27(56): 13991-13997, 2021 Oct 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34382264
10.
A new road to STING activation.
Nat Chem Biol
; 20(3): 266-267, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-37833569
11.
Modulators of immunoregulatory exonucleases PLD3 and PLD4 identified by high-throughput screen.
Bioorg Med Chem Lett
; 49: 128293, 2021 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34332037
12.
Synthetic fluorescent MYC probe: Inhibitor binding site elucidation and development of a high-throughput screening assay.
Bioorg Med Chem
; 42: 116246, 2021 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34130216
13.
Discovery and SAR studies of 3-amino-4-(phenylsulfonyl)tetrahydrothiophene 1,1-dioxides as non-electrophilic antioxidant response element (ARE) activators.
Bioorg Chem
; 108: 104614, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33508678
14.
Metabolomics-based discovery of a metabolite that enhances oligodendrocyte maturation.
Nat Chem Biol
; 14(1): 22-28, 2018 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-29131145
15.
A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers.
Proc Natl Acad Sci U S A
; 114(46): E9903-E9912, 2017 11 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29087350
16.
Small molecule-mediated inhibition of myofibroblast transdifferentiation for the treatment of fibrosis.
Proc Natl Acad Sci U S A
; 114(18): 4679-4684, 2017 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28416697
17.
A regenerative approach to the treatment of multiple sclerosis.
Nature
; 502(7471): 327-332, 2013 Oct 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-24107995
18.
Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers.
Proc Natl Acad Sci U S A
; 113(7): 1778-83, 2016 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-26831078
19.
Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors.
Biochemistry
; 57(47): 6604-6614, 2018 11 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30365304
20.
Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma.
Bioorg Med Chem Lett
; 28(16): 2675-2678, 2018 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29731362