Detalhe da pesquisa
1.
A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing.
Molecules
; 23(3)2018 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29498707
2.
Isophthalic Acid-Based HDAC Inhibitors as Potent Inhibitors of HDAC8 from Schistosoma mansoni.
Arch Pharm (Weinheim)
; 350(8)2017 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-28639720
3.
Epigenetic changes modulate schistosome egg formation and are a novel target for reducing transmission of schistosomiasis.
PLoS Pathog
; 10(5): e1004116, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24809504
4.
Fast evolutionary rates associated with functional loss in class I glucose transporters of Schistosoma mansoni.
BMC Genomics
; 16: 980, 2015 Nov 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-26584526
5.
Structural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoni.
PLoS Pathog
; 9(9): e1003645, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24086136
6.
Chromatin regulation in schistosomes and histone modifying enzymes as drug targets.
Mem Inst Oswaldo Cruz
; 106(7): 794-801, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22124550
7.
Synthesis, structure-activity relationships, cocrystallization and cellular characterization of novel smHDAC8 inhibitors for the treatment of schistosomiasis.
Eur J Med Chem
; 225: 113745, 2021 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34392190
8.
Histone deacetylase 8 interacts with the GTPase SmRho1 in Schistosoma mansoni.
PLoS Negl Trop Dis
; 15(11): e0009503, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34843489
9.
Structure-Based Design, Synthesis, and Biological Evaluation of Triazole-Based smHDAC8 Inhibitors.
ChemMedChem
; 15(7): 571-584, 2020 04 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31816172
10.
Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma mansoni.
PLoS Negl Trop Dis
; 14(7): e0008332, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32609727
11.
Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from Schistosoma mansoni (SmSirt2).
J Med Chem
; 62(19): 8733-8759, 2019 10 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31496251
12.
Synthesis, Crystallization Studies, and in vitro Characterization of Cinnamic Acid Derivatives as SmHDAC8 Inhibitors for the Treatment of Schistosomiasis.
ChemMedChem
; 13(15): 1517-1529, 2018 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29806110
13.
Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.
J Med Chem
; 61(22): 10000-10016, 2018 11 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-30347148
14.
Analysis of the interactome of Schistosoma mansoni histone deacetylase 8.
PLoS Negl Trop Dis
; 11(11): e0006089, 2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-29155817
15.
Effect of clinically approved HDAC inhibitors on Plasmodium, Leishmania and Schistosoma parasite growth.
Int J Parasitol Drugs Drug Resist
; 7(1): 42-50, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28107750
16.
Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis.
J Med Chem
; 59(6): 2423-35, 2016 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26937828
17.
Fluorescence-based screening assays for the NADâº-dependent histone deacetylase smSirt2 from Schistosoma mansoni.
J Biomol Screen
; 20(1): 112-21, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25325257
18.
Schistosome sirtuins as drug targets.
Future Med Chem
; 7(6): 765-82, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25996069
19.
Epigenetic control of gene function in schistosomes: a source of therapeutic targets?
Front Genet
; 5: 317, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25309576
20.
Compound library screening identified Akt/PKB kinase pathway inhibitors as potential key molecules for the development of new chemotherapeutics against schistosomiasis.
Int J Parasitol Drugs Drug Resist
; 4(3): 256-66, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25516836