Detalhe da pesquisa
1.
Efficacy and Safety of a Recombinant Plant-Based Adjuvanted Covid-19 Vaccine.
N Engl J Med
; 386(22): 2084-2096, 2022 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35507508
2.
Efficacy, immunogenicity, and safety of a plant-derived, quadrivalent, virus-like particle influenza vaccine in adults (18-64 years) and older adults (≥65 years): two multicentre, randomised phase 3 trials.
Lancet
; 396(10261): 1491-1503, 2020 11 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33065035
3.
Prime-pull vaccination with a plant-derived virus-like particle influenza vaccine elicits a broad immune response and protects aged mice from death and frailty after challenge.
Immun Ageing
; 16: 27, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31700523
4.
A plant-derived quadrivalent virus like particle influenza vaccine induces cross-reactive antibody and T cell response in healthy adults.
Clin Immunol
; 168: 72-87, 2016 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-26987887
5.
Generation and characterization of a trackable plant-made influenza H5 virus-like particle (VLP) containing enhanced green fluorescent protein (eGFP).
FASEB J
; 29(9): 3817-27, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26038124
6.
Biochemical composition of haemagglutinin-based influenza virus-like particle vaccine produced by transient expression in tobacco plants.
Plant Biotechnol J
; 13(5): 717-25, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25523794
7.
Influenza virus-like particle vaccines made in Nicotiana benthamiana elicit durable, poly-functional and cross-reactive T cell responses to influenza HA antigens.
Clin Immunol
; 154(2): 164-77, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25128897
8.
Development and characterization of a plant-derived norovirus-like particle vaccine.
Vaccine
; 41(41): 6008-6016, 2023 09 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37625992
9.
Lack of effects on female fertility or pre- and postnatal development of offspring in rats after exposure to AS03-adjuvanted recombinant plant-derived virus-like particle vaccine candidate for COVID-19.
Reprod Toxicol
; 107: 69-80, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34838689
10.
Elimination of receptor binding by influenza hemagglutinin improves vaccine-induced immunity.
NPJ Vaccines
; 7(1): 42, 2022 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35410323
11.
Durability and cross-reactivity of immune responses induced by a plant-based virus-like particle vaccine for COVID-19.
Nat Commun
; 13(1): 6905, 2022 11 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36371408
12.
Safety, immunogenicity, and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates.
Cell Mol Immunol
; 19(2): 222-233, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34983950
13.
Safety and immunogenicity of an AS03-adjuvanted plant-based SARS-CoV-2 vaccine in Adults with and without Comorbidities.
NPJ Vaccines
; 7(1): 142, 2022 Nov 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36351931
14.
Phase III: Randomized observer-blind trial to evaluate lot-to-lot consistency of a new plant-derived quadrivalent virus like particle influenza vaccine in adults 18-49 years of age.
Vaccine
; 39(10): 1528-1533, 2021 03 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33581920
15.
Phase 1 randomized trial of a plant-derived virus-like particle vaccine for COVID-19.
Nat Med
; 27(6): 1071-1078, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34007070
16.
The production of hemagglutinin-based virus-like particles in plants: a rapid, efficient and safe response to pandemic influenza.
Plant Biotechnol J
; 8(5): 607-19, 2010 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-20199612
17.
A plant-derived VLP influenza vaccine elicits a balanced immune response even in very old mice with co-morbidities.
PLoS One
; 14(1): e0210009, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30629622
18.
Immunogenicity and safety of a quadrivalent plant-derived virus like particle influenza vaccine candidate-Two randomized Phase II clinical trials in 18 to 49 and ≥50 years old adults.
PLoS One
; 14(6): e0216533, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31166987
19.
Plant-derived virus-like particle vaccines drive cross-presentation of influenza A hemagglutinin peptides by human monocyte-derived macrophages.
NPJ Vaccines
; 4: 17, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31123605
20.
The establishment of surrogates and correlates of protection: Useful tools for the licensure of effective influenza vaccines?
Hum Vaccin Immunother
; 14(3): 647-656, 2018 03 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29252098