Quantitative laryngeal electromyography parameters may correlate with improved outcomes following botulinum toxin injection for spasmodic dysphonia.

BACKGROUND: Despite use of qualitative laryngeal electromyography (LEMG) guided botulinum toxin A (BoNT-A) injection for treatment of adductor spasmodic dysphonia (AdSD), unsatisfactory injections and complete "misses" remain problematic. We aimed to determine if the quantitative LEMG measure of number of small segments (NSS) correlates with voice outcomes following (BoNT-A injection for AdSD. METHODS: Automated quantitative LEMG analysis was performed during electromyography (EMG) -guided BoNT-A injection into the thyroarytenoid-lateral cricoarytenoid muscle complex for treatment of AdSD. Pre-injection phonatory NSS values were correlated with clinical voice outcomes and patient reported injection results. RESULTS: Quantitative LEMG measures were obtained for 45 AdSD patients (28 female, mean age 60.8 ± 12.8 years) during EMG-guided BoNT-A injection. Mean sampled NSS during phonation immediately prior to BoNT-A injection was 524 ± 323 (range: 2-904). Mean follow up was 36.5 ± 9.4 days; one patient was lost to follow-up. In comparison to their previous BoNT-A injection, the current injection was rated as worse, same, and better by 13 (29.5%), 25 (56.8%), and 6 (13.6%) patients, respectively. All 4 (9.1%) patients with NSS < 200 rated their BoNT-A injection result as worse than previous, and change in Voice Handicap Index-10 (VHI-10) scores were worse or without change. CONCLUSIONS: Aiming for an NSS value greater than 200 during phonation prior to BoNT-A toxin injection for AdSD may reduce unfavorable voice outcomes.

Appropriateness for SARS-CoV-2 vaccination for otolaryngologist and head and neck surgeons in case of pregnancy, breastfeeding, or childbearing potential: Yo-IFOS and CEORL-HNS joint clinical consensus statement.

PURPOSE: SARS-CoV-2 vaccines are a key step in fighting the pandemic. Nevertheless, their rapid development did not allow for testing among specific population subgroups such as pregnant and breastfeeding women, or elaborating specific guidelines for healthcare personnel working in high infection risk specialties, such as otolaryngology (ORL). This clinical consensus statement (CCS) aims to offer guidance for SARS-CoV-2 vaccination to this high-risk population based on the best evidence available. METHODS: A multidisciplinary international panel of 33 specialists judged statements through a two-round modified Delphi method survey. Statements were designed to encompass the following topics: risk of SARS-Cov-2 infection and use of protective equipment in ORL; SARS-Cov-2 infection and vaccines and respective risks for the mother/child dyad; and counseling for SARS-CoV-2 vaccination in pregnant, breastfeeding, or fertile healthcare workers (PBFHW). All ORL PBFHW were considered as the target audience. RESULTS: Of the 13 statements, 7 reached consensus or strong consensus, 2 reached no consensus, and 2 reached near-consensus. According to the statements with strong consensus otorhinolaryngologists-head and neck surgeons who are pregnant, breastfeeding, or with childbearing potential should have the opportunity to receive SARS-Cov-2 vaccination. Moreover, personal protective equipment (PPE) should still be used even after the vaccination. CONCLUSION: Until prospective evaluations on these topics are available, ORL-HNS must be considered a high infection risk specialty. While the use of PPE remains pivotal, ORL PBFHW should be allowed access to SARS-CoV-2 vaccination provided they receive up-to-date information.

Assessing the acceptability of script concordance testing: a nationwide study in otolaryngology.

Background: Script concordance testing (SCT) is an objective method to evaluate clinical reasoning that assesses the ability to interpret medical information under conditions of uncertainty. Many studies have supported its validity as a tool to assess higher levels of learning, but little is known about its acceptability to major stakeholders. The aim of this study was to determine the acceptability of SCT to residents in otolaryngology ­ head and neck surgery (OTL-HNS) and a reference group of experts. Methods: In 2013 and 2016, a set of SCT questions, as well a post-test exit survey, were included in the National In-Training Examination (NITE) for OTL-HNS. This examination is administered to all OTL-HNS residents across Canada who are in the second to fifth year of residency. The same SCT questions and survey were then sent to a group of OTL-HNS surgeons from 4 Canadian universities. Results: For 64.4% of faculty and residents, the study was their first exposure to SCT. Overall, residents found it difficult to adapt to this form of testing, thought that the clinical scenarios were not clear and believed that SCT was not useful for assessing clinical reasoning. In contrast, the vast majority of experts felt that the test questions reflected real-life clinical situations and would recommend SCT as an evaluation method in OTL-HNS. Conclusion: Views about the acceptability of SCT as an assessment tool for clinical reasoning differed between OTL-HNS residents and experts. Education about SCT and increased exposure to this testing method are necessary to improve residents' perceptions of SCT.

Contexte: Le test de concordance de script (TCS) est une méthode objective d'évaluation du raisonnement clinique qui mesure la capacité d'interpréter les renseignements médicaux en contexte d'incertitude. Beaucoup d'études en appuient la validité en tant qu'outil pour évaluer l'enseignement supérieur, mais on en sait peu sur son acceptabilité auprès des principales parties prenantes. Le but de cette étude était de déterminer l'acceptabilité du TCS chez les résidents en otorhinolaryngologie ­ chirurgie de la tête et du cou (ORL ­ chirurgie tête et cou) et un groupe de référence composé d'experts. Méthodes: En 2013 et 2016, une série de questions de TCS, de même qu'un questionnaire post-test, ont été inclus dans l'examen national en cours de formation NITE (National In-Training Examination) pour l'ORL ­ chirurgie tête et cou. Cet examen est administré à tous les résidents en ORL ­ chirurgie tête et cou au Canada qui sont entre leurs deuxième et cinquième années de résidence. Les mêmes questions de TCS ont été envoyées à un groupe de chirurgiens en ORL ­ chirurgie tête et cou de 4 université canadiennes. Résultats: Pour 64,4 % des membres facultaires et des résidents, l'étude était leur première exposition au TCS. Dans l'ensemble, les résidents ont trouvé difficile de s'adapter à cette forme de test, même si les scénarios cliniques étaient clairs, et ils ont estimé que le TCS était peu utile pour évaluer le raisonnement clinique. En revanche, la grande majorité des experts ont jugé que les questions du test reflétaient la réalité des cas cliniques et recommanderaient le TCS comme méthode d'évaluation en ORL ­ chirurgie tête et cou. Conclusion: Entre les résidents et les experts en ORL ­ chirurgie tête et cou, les points de vue quant à l'acceptabilité du TCS comme outil d'évaluation du raisonnement clinique ont différé et il faudrait y exposer les résidents davantage pour améliorer leur perception du TCS.

Inconsistencies between measures of cognitive dysfunction in childhood acute lymphoblastic leukemia survivors: Description and understanding.

OBJECTIVES: The frequency of cognitive difficulties in childhood cancer survivors varies according to the measurement strategy. The goal of this research is to (a) describe agreements and differences between measures of working memory and attention (b) identify contributors of these differences, such as emotional distress, affects, and fatigue. METHODS: We used data available for 138 adults successfully treated for childhood acute lymphoblastic leukemia (ALL) (PETALE cohort). Working memory and attention were assessed using subtests from the WAIS-IV and self-reported questionnaires (BRIEF-SR and CAARS-S:L). Potential contributors included emotional distress, anxiety, depression (BSI-18), affects (PANAS), and fatigue (PedsQL-MFS). We explored measurement agreements and differences using diagnostic indices and multivariate regression models. RESULTS: The frequencies of working memory and attention deficits were higher when using cognitive tests (15%-21%) than with self-reports (10%-11%). Self-reported questionnaires showed high specificity (median 0.87) and low sensitivity (median 0.10), suggesting they did not reliably identify positive cases on cognitive tests. We identified negative affectivity as a possible contributor to inconsistencies between self-report and test results. CONCLUSIONS: When measuring working memory and attention in childhood ALL survivors, cognitive test results and self-reports should not be considered equivalent. At best, self-report may be used for screening (high specificity), but not to assess prevalence in large samples. Self-reported difficulties are also probably influenced by the negative mood in this population.

Strategies for CO2 Laser Use in Laryngeal Microsurgery: A Systematic Review.

OBJECTIVE: We aim to systematically review the literature addressing perioperative practices for optimal use of the CO2 laser in laryngeal transoral laser microsurgery (TOLMS), with a focus on safety. DATA SOURCES: A systematic review of publications indexed in Medline, Embase, and EBM reviews-Cochrane Central Register of Controlled Trials which evaluated perioperative strategies for the use of CO2 laser in laryngeal TOLMS was conducted. REVIEW METHODS: Records obtained from the search strategy were assessed for eligibility in a 2-step process by 2 independent researchers using the Covidence software. RESULTS: Among 2143 identified records, 103 were included in this study. The majority of studies (n = 25) focused on the use of the CO2 laser in oncologic resection, while 20 addressed the treatment of vocal cord paralysis, 16 discussed the treatment of pediatric or congenital pathologies, 11 detailed the management of benign lesions, and 31 studies tackled other surgical indications. Strategies for safe CO2 TOLMS were highly heterogeneous across studies and included preoperative measures (ie, related to the environment, staff preparation, patient protection, and ventilation), intraoperative precautions (ie, protection of nontarget structures, technical considerations, topical and systemic medications), and postoperative strategies (ie, related to airway protection, oral intake, vocal rest, hospitalization duration, drug regimen, and consultant follow-up). CONCLUSION: The results provided in this study can be used as a framework to guide the creation of laser safety protocols across institutions, guide quality improvement initiatives, the development of simulation training activities, and as a tool to facilitate resident teaching and skill assessment.

Quebec French Translation, Cultural Adaptation, and Validation of the Singing Voice Handicap Index-10 Questionnaire for Singers with Dysphonia.

OBJECTIVES/HYPOTHESIS: Dysphonia is a common voice disorder that can significantly impact a person's life; it requires a collaborative evaluation by both speech-language pathologists and otolaryngologists that takes the patient's perspective into account. The aim of this study was to translate and culturally adapt the Singing Voice Handicap Index questionnaire (SVHI-10), a reliable patient-reported outcome evaluation tool for dysphonia, for the Quebec French population. The result is the Singing Voice Handicap Index-10-QC (SVHI-10-QC). STUDY DESIGN: This study was a prospective translation and validation process. METHODS: The translation process complied with international recommendations and followed a standard forward-backward translation procedure and cognitive debriefing with 10 singers. The Quebec French version was administered to two study samples: 30 vocal professionals with no dysphonia and 53 vocal professionals with dysphonia as one of their primary complaints. The SVHI-10-QC was assessed for construct validity, internal consistency, discriminatory capacity, and test-retest reliability. RESULTS: The SVHI-10-QC is valid, reliable, and ready for use with singer-patients suffering from dysphonia. CONCLUSIONS: The SVHI-10-QC is a reliable and valid tool for assessing the impact of dysphonia on French Quebec singers' quality of life.

Cannabis Consumption Among Patients With a Voice Disorder: A Multicenter E-Survey Study.

INTRODUCTION: Legalization of cannabis consumption in the United States (U.S.) has increased rapidly, impacting consumption rates in the general U.S. POPULATION: The objective of this survey study was to establish prevalence estimates of cannabis consumption among voice patients, in addition to characterizing patterns of cannabis consumption. METHODS: A multicenter, anonymous survey study of cannabis consumption took place at multidisciplinary tertiary voice care clinics in Portland, Oregon (PDX) and Pittsburgh, Pennsylvania (PIT) between April 2017 and December 2018. A convenience sample of 300 consecutively enrolled English-speaking patients 21 years and older with a voice disorder completed the survey. Data were obtained on the prevalence of cannabis consumption, frequency and methods of cannabis consumption, in addition to health impacts and demographics. RESULTS: Agresti-Coull prevalence proportion estimates for cannabis consumption were higher among voice patients in PDX compared to PIT. Current consumers in PDX and PIT showed a similar frequency of cannabis consumption. Combustion methods (eg, joint) were more popular than non-combustion methods (eg, vaping) among current consumers; inhaled methods (eg, joint) were more popular than non-inhaled methods (eg, edibles). Though vocal handicap scores for current consumers were similar across sites and comparable to lifetime non-consumers who also were non-smokers of tobacco, a lifetime history of cannabis consumption was associated with vocal and overall health impacts. CONCLUSIONS: Prevalence estimates for current cannabis consumption among voice patients from tertiary voice care clinics mirrored prevalence estimates reported for large, representative samples from Oregon and Pennsylvania. These findings provide valuable insight on the extent of cannabis consumption among voice patients.

Creation and Implementation of the UCSF Laryngeal Symptom Diary for Trial Vocal Fold Injection.

OBJECTIVES: Patient recollection of their trial vocal fold injection outcomes is crucial in determining future treatment. This study aims to assess a new clinical tool, the UCSF Laryngeal Symptom Diary, for its ease of use, clinical value in patient symptom tracking, and utility for long-term decision-making following trial vocal fold injection. MATERIALS AND METHODS: In this prospective cohort study, consecutive patients undergoing trial vocal fold injection between June 2019 and January 2020 completed the UCSF Laryngeal Symptom Diary. Patients rated standardized and customized laryngeal symptoms weekly. Upon follow-up, a survey pertaining to the diary was completed by both the patient and treating laryngologist. RESULTS: A total of 29 patients opted to participate and were provided with the UCSF Laryngeal Symptom Diary. The diary was returned by 82.3% (n = 24/29) of patients. Mean time to follow up was 5.98 weeks. Survey participation rate was 93.1% (n = 27/29). From the patients' perspective, 66.7% (n = 18/27) found the diary useful in following their symptom evolution. Treating laryngeal surgeon noted excellent concordance between diary entries and patient's overall injection benefit (91.7%, n = 22/24). The diary was useful in clinician-recommendation of subsequent treatment options in 70.8% (n = 17/24) of patients. CONCLUSION: The UCSF Laryngeal Symptom Diary is a patient friendly clinical tool for trial vocal fold injection that facilitates patient tracking of symptom evolution and helps guide treating clinicians in subsequent treatment planning.

Abnormal Laryngeal Electromyography Findings in Asymptomatic Adults Across the Age Spectrum.

OBJECTIVES/HYPOTHESIS: Laryngeal electromyography (LEMG) is a diagnostic tool for patients with suspected neurogenic abnormalities of the larynx. LEMG is often used with the assumption that any abnormality is symptom-/disease-related. We sought to determine the prevalence of abnormal LEMG findings in a group of healthy asymptomatic adults across a large age spectrum. STUDY DESIGN: Open, prospective study, gender-match and age balanced by decade. METHODS: Forty-six healthy participants (age 20-78) underwent LEMG, including 178 muscles. Participants had no history of voice problems, normal VHI-10, and normal flexible laryngoscopy. Qualitative and quantitative LEMG (bilateral) were performed involving the thyroarytenoid-lateral cricoarytenoid muscle complex (TA-LCA) and cricothyroid (CT) muscles. LEMG parameters included evaluation for fibrillation potentials, sharp waves, reduced recruitment, polyphasic potentials, electrical synkinesis, and measurement of turns per second. RESULTS: Of participants, 4% had at least one abnormal qualitative finding (slightly reduced recruitment or two to three discrete polyphasic potentials). There were no findings of fibrillation potentials or sharp waves. There were no abnormal qualitative findings in the CT muscles tested. Of participants, 16% had at least one abnormal synkinesis finding. LEMG qualitative abnormalities and quantitative abnormalities do not appear to correlate with gender or age. CONCLUSION: Abnormal qualitative and quantitative LEMG findings were uncommon and minor in severity in our group of asymptomatic healthy adults. The likelihood of abnormal LEMG results in asymptomatic adults was 2.2% for qualitative findings, 9.3% for synkinesis, and 5.4% for turns/s. LEVEL OF EVIDENCE: 3 Laryngoscope, 131:2065-2069, 2021.

The prevalence of cognitive impairment in laryngology treatment-seeking patients.

OBJECTIVES/HYPOTHESIS: The incidence of cognitive impairment (CI) in the elderly general population is 10% to 20%. The incidence of CI in the elderly laryngology treatment-seeking population is unknown, and CI may impact decision making for elective medical/surgical treatment and negatively impact the outcome of voice/swallowing therapy. We sought to determine the prevalence of CI in elderly patients who are seeking laryngology care and to evaluate the feasibility of administering a cognitive screening instrument. STUDY DESIGN: Prospective, Cross-sectional. METHODS: One hundred fifty patients (≥65 years old) without a previous diagnosis of CI, seeking laryngology evaluation, were administered the Montreal Cognitive Assessment (MoCA) test by a trained physician. Other members of the clinical team were blinded to the MoCA results. RESULTS: Twenty-five percent of participants obtained a score diagnostic for at least mild CI. The results showed a correlation between the MoCA scores and 1) the time needed to complete the test, 2) participant age, and 3) participant education level. No differences were observed between gender, alcohol consumption, or use of medications that can affect cognition and MoCA score. CONCLUSION: One in four elderly laryngology treatment-seeking patients were found to have undiagnosed CI. This finding warrants consideration for CI screening for these patients being evaluated for voice therapy and elective surgery. Treatment decision making in this population may benefit from additional family involvement. LEVEL OF EVIDENCE: 2c Laryngoscope, 130: 2003-2007, 2020.