Racial/Ethnic Differences in 30-Year Trajectories of Cannabis Use among Males.

Background: Given that cannabis is the most commonly used illicit substance in the US, continuous research on patterns of cannabis use over the life course can help to ensure progress towards improving public health and reducing health inequalities across race/ethnicity. Thus, we examine racial/ethnic differences in cannabis use trajectories among males across two overlapping stages of the life course. Methods: We use data from two companion studies, the Rochester Youth Development Study (RYDS - a longitudinal cohort study that followed participants from adolescence into adulthood), and its intergenerational extension - the Rochester Intergenerational Study. For Life Stage 1, we consider cannabis use during the transition from adolescence to adulthood (spanning ages 13 to 33; 439 Black, 128 White, and 125 Hispanic males). Among these males who became fathers, we consider cannabis use during fatherhood (Life Stage 2 -spanning the period of time when their firstborn child was between the ages of 7 and 17-217 Black, 55 White, and 56 Hispanic males). Ordinal generalized estimating equations were specified to examine cannabis use trajectories during both stages of the males' lives. Results: No significant differences in cannabis use as a function of racial/ethnic group were found during the transition from adolescence to adulthood (Life Stage 1). All groups had a peak of cannabis use in the early to mid-20's followed by a decline in use. During fatherhood (Life Stage 2), cannabis use was stable for all groups, but Black fathers reported more frequent cannabis use on average than Hispanic fathers. Conclusions: The increase in cannabis use well past adolescence for all groups suggests the potential importance of intervention initiatives during the transition to adulthood. The more frequent use of cannabis by Black fathers warrants further study given the impact parental cannabis use can have on offspring.

Correction to: Does Organizing Mentor-Mentee Matches into Small Groups Enhance Treatment Effects in a Site-Based Mentoring Program for Adolescents? Results of a Randomized Controlled Trial.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Does Organizing Mentor-Mentee Matches into Small Groups Enhance Treatment Effects in a Site-Based Mentoring Program for Adolescents? Results of a Randomized Controlled Trial.

Formal youth mentoring is an effective intervention strategy for healthy development during adolescence. Modest and varied effects across programs, however, demonstrate a need to identify factors that can reliably improve outcomes for mentored youth. The purpose of this randomized controlled trial was to test the relative impact of embedding mentee-mentor matches in small groups on youth outcomes and to examine whether this effect was mediated by the quality of the program setting and mentoring relationship quality. Participants included 676 adolescents (Mage = 14.21, range = 11-18; 41.6% female) enrolled in Campus Connections, a site-based youth mentoring program. Most measured outcomes in both conditions (i.e., mentoring groups and a control condition in which pairs were not embedded in a group) were significantly better at post-intervention as compared to pre-intervention. The hypothesis that mentoring groups would have stronger impact, however, was not supported. The results imply that organizing mentor-mentee matches in small groups offer no advantage or disadvantage and that youth may be able to garner benefit from both structures.

Stability and Change in Men's Intimate Partner Violence and Substance Use in Early Adulthood.

Despite substantial evidence of the role of substance use in intimate partner violence (IPV), little is known about the impact of substance use on stability and change in the experience of IPV as both a perpetrator and a victim. Using an ethnically diverse sample of 232 men in early adulthood (mean age = 29.1, SD = 0.91), this study defined typologies of IPV based on men's reports of both perpetration and victimization; examined the potential impact of substance use, including alcohol and marijuana use, on IPV typologies over two measurement occasions; and quantified stability and change in these typologies over time. Patterns of IPV were characterized by three classes at each time point: no IPV, psychological aggression, and physical aggression. Men's regular marijuana use was associated with physical aggression contemporaneously and prospectively. Partner's problem alcohol use was associated with psychological aggression contemporaneously, suggesting that women's problem alcohol use could be a risk factor for their own and their partner's IPV perpetration. IPV appeared to remain somewhat stable over time with 67% of men remaining in the same IPV class. Among those who did transition from one typology to another, it was most often to a less severe IPV typology. Regular marijuana users were more likely to be in the physical aggression typology rather than the no IPV typology, with a higher probability of transitioning to a more severe IPV typology than nonusers. The present study has implications for prevention and intervention efforts by its ability to identify men who are at greatest risk for continued or increased violence and underscores that men's marijuana use may exacerbate IPV.

COVID-19 family dynamics and health protective behavior adherence: A 16-wave longitudinal study.

OBJECTIVE: Health-protective behavior (HPB) adherence (wearing protective face masks, social distancing, and increased handwashing) plays a critical role in reducing infectious disease transmission; yet factors underlying HPB adherence are not well understood. Most research focuses on individual factors-beliefs about susceptibility, severity, and HPB efficacy; however, understanding parent and child HPB adherence may require a family conceptualization. This study evaluated whether family relations (cohesion, conflict, and chaos), as well as parent-child conflict regarding pandemic-specific circumstances (e.g., social distancing prohibitions about spending time with friends) account for parent and child HPB adherence, over and above parents' individual concerns about COVID-19 risks. METHOD: This study utilized data reported by parents in 204 families with children (Mage = 4.2; 45% girls) collected on 16 occasions between May 2020 through April 2021. The impact of within-person (WP) and between-person (BP) effects of each family-level factor on parent and child HPB adherence was evaluated in a series of two-level multilevel models. RESULTS: Over the course of the study, parent HPB adherence was generally stable and child HPB adherence declined early on but then leveled off. Results showed the protective effect of family cohesion for both parent and child HPB adherence at the WP and BP level. In addition, periods of higher COVID-19-related conflict corresponded to increases in parent and child HPB adherence. CONCLUSIONS: Intervention efforts should be directed at promoting family cohesion in order to promote sustained parent and child HPB adherence. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Adolescent Substance Use Prevention: Long-Term Benefits of School Engagement.

BACKGROUND: To determine if school engagement is a viable target for early prevention of adolescent substance use, this study investigated whether school engagement in early adolescence (ages 12-14) is a cause of alcohol and cannabis use during middle to late adolescence (ages 15-19). METHODS: To facilitate causal inference, inverse probability of treatment weights (IPTWs), which are based on estimated probabilities of treatment selection (ie, school engagement), were created based on a robust set of potential confounders. Using the IPTWs, a cumulative link mixed model was fit to examine the impact of school engagement on alcohol and cannabis use among an ethnically diverse sample of adolescents (N = 360). RESULTS: School engagement was associated with a lower level of alcohol and cannabis use from age 15 to 18. School engagement was not associated with change in alcohol and cannabis use over time, suggesting that school engagement emits its effect early in the developmental course of substance use and offers protection throughout adolescence. CONCLUSIONS: This study supports a compensatory role of early school engagement in substance use across middle and late adolescence. School engagement is a malleable factor and thus offers an avenue for prevention efforts.

Two-Part Models for Father-Child Relationship Variables: Presence in the Child's Life and Quality of the Relationship Conditional on Some Presence.

Parent-child relationship variables are often measured using a two-part approach. For example, when assessing the warmth of the father-child relationship, a child is first asked if they have contact with their father; if so, the level of warmth they feel toward him is ascertained. In this setting, data on the warmth measure is missing for children without contact with their father, and such missing data can pose a significant methodological and substantive challenge when the variable is used as an outcome or antecedent variable in a model. In both cases, it is advantageous to use an analytic method that simultaneously models whether the child has contact with the father, and if they do, the degree to which the father-child relationship is characterized by warmth. This is particularly relevant when the two-part variable is measured over time, as contact status may change. We offer a pragmatic tutorial for using two-part variables in regression models, including a brief overview of growth modeling, an explanation of the techniques to handle two-part variables as predictors and outcomes in the context of growth modeling, examples with real data, and syntax in both R and Mplus for fitting all discussed models.

Antioxidative effects of quercetin-glycosides isolated from the flower buds of Tussilago farfara L.

A bioassay-guided fractionation of the ethylacetate soluble fraction from the flower buds of Tussilago farfara L. (Compositae) yielded two flavonoids, quercetin 3-O-beta-L-arabinopyranoside and quercetin 3-O-beta-D-glucopyranoside. These two sugar conjugates of quercetin exhibited higher antioxidative activity than their aglycone, quercetin by NBT superoxide scavenging assay. Moreover, treatment with quercetin 3-O-beta-L-arabinopyranoside significantly increased the total glutathione (GSH) contents and the protein level of gamma-glutamylcysteine ligase (gamma-GCL), a key enzyme required for glutathione (GSH) synthesis in a rat hepatocyte cell line. Subcellular fractionation and reporter gene analysis using antioxidant response element (ARE) construct revealed that quercetin 3-O-beta-L-arabinopyranoside increased the level of nuclear Nrf2 and reporter activity, and that these were associated with the induction of the gamma-GCL gene. After 24 h incubation of cells with quercetin 3-O-beta-L-arabinopyranoside, 23% of the glycoside was converted to its aglycone, quercetin, but gamma-GCL was not induced by 7 microM (23%) quercetin. These results suggest that the two quercetin-glycosides isolated from T. farfara L. have direct antioxidative properties, and that quercetin 3-O-beta-L-arabinopyranoside increases the cellular GSH level by inducing the gamma-GCL gene. These novel effects of quercetin-glycosides are suggestive to underlie the potential putative chemopreventive effects of T. farfara L.

Pentacyclic triterpenoids and their cytotoxicity from the stem bark of Styrax japonica S. et Z.

The methylene chloride soluble fraction of MeOH extract from the stem bark of Styrax japonica S. et Z. (Styracaceae) showed significant cytotoxicity by SRB method against five human tumor cell lines. Four known pentacyclic triterpenoids, oleanolic aldehyde acetate (1), erythrodiol-3-acetate (2), euphorginol (3), and anhydrosophoradiol-3-acetate (4) were isolated by activity-guided fractionation. Their structures were determined by chemical and spectral analysis. Compounds 1-4 were isolated from S. japonica for the first time.

A new phenolic amide from Lycium chinense Miller.

A new phenolic amide, dihydro-N-caffeoyltyramine (1) was isolated from the root bark of Lycium chinense Miller, along with known compounds, trans-N-caffeoyltyramine (2), cis-N-caffeoyltyramine (3), and lyoniresinol 3alpha-O-beta-D-glucopyranoside (4). Their structures were determined by spectroscopic analysis. A NBT superoxide scavenging assay revealed that three phenolic amides showed potent antioxidative activity.

Structure-antiviral activity relationships of cecropin A-magainin 2 hybrid peptide and its analogues.

In order to elucidate the structure-antiviral activity relationship of cecropin A (1-8)-magainin 2 (1-12) (termed CA-MA) hybrid peptide, several analogues with amino acid substitutions were synthesized. In a previous study, it was shown that serine at position 16 in CA-MA hybrid peptide was very important for antimicrobial activity. Analogues were designed to increase the hydrophobic property by substituting a hydrophobic amino acid residue (S --> A, V, F or W, position 16) in the CA-MA hybrid peptide. In this study, the structure-antiviral activity relationships of CA-MA and its analogues were investigated. In particular, substitution of Ser with a hydrophobic amino acid, Val, Phe or Trp at position 16 caused a dramatic increase in the virus-cell fusion inhibitory activity. These results suggested that the hydrophobicity at position 16 in the hydrophobic region of CA-MA is important for potent antiviral activity.