Detalhe da pesquisa
1.
Cost-effectiveness of implantable ventricular assist devices in older children with stable, inotrope-dependent dilated cardiomyopathy.
Pediatr Transplant
; 25(4): e13975, 2021 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-33481355
2.
Pharmacologic Characterization of AMG8379, a Potent and Selective Small Molecule Sulfonamide Antagonist of the Voltage-Gated Sodium Channel NaV1.7.
J Pharmacol Exp Ther
; 362(1): 146-160, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28473457
3.
Development of novel azabenzofuran TRPA1 antagonists as in vivo tools.
Bioorg Med Chem Lett
; 24(15): 3464-8, 2014 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24953819
4.
Development of a time-resolved fluorescence resonance energy transfer assay for cyclin-dependent kinase 4 and identification of its ATP-noncompetitive inhibitors.
Anal Biochem
; 421(2): 368-77, 2012 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22056947
5.
Discovery of alpha-amidosulfones as potent and selective agonists of CB2: synthesis, SAR, and pharmacokinetic properties.
Bioorg Med Chem Lett
; 19(1): 31-5, 2009 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19062274
6.
Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation.
J Med Chem
; 51(6): 1681-94, 2008 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-18321037
7.
N-(3-(phenylcarbamoyl)arylpyrimidine)-5-carboxamides as potent and selective inhibitors of Lck: structure, synthesis and SAR.
Bioorg Med Chem Lett
; 18(3): 1172-6, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18083554
8.
Structural modifications of N-arylamide oxadiazoles: Identification of N-arylpiperidine oxadiazoles as potent and selective agonists of CB2.
Bioorg Med Chem Lett
; 18(15): 4267-74, 2008 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18640038
9.
Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V.
PLoS One
; 13(5): e0196791, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29723257
10.
Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity.
J Med Chem
; 49(16): 4981-91, 2006 Aug 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-16884310
11.
Discovery of aminoquinazolines as potent, orally bioavailable inhibitors of Lck: synthesis, SAR, and in vivo anti-inflammatory activity.
J Med Chem
; 49(19): 5671-86, 2006 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-16970394
12.
Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity.
J Med Chem
; 59(6): 2794-809, 2016 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26942860
13.
Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors.
J Med Chem
; 59(17): 7818-39, 2016 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27441383
14.
CD8-interaction mutant HLA-Cw3 molecules protect porcine cells from human natural killer cell-mediated antibody-dependent cellular cytotoxicity without stimulating cytotoxic T lymphocytes.
Transplantation
; 76(11): 1615-22, 2003 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-14702534
15.
Differential selectivity of JAK2 inhibitors in enzymatic and cellular settings.
Exp Hematol
; 41(5): 491-500, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23340136
16.
High-throughput TR-FRET assays for identifying inhibitors of LSD1 and JMJD2C histone lysine demethylases.
J Biomol Screen
; 17(1): 27-38, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21859682
17.
Discovery of potent and highly selective thienopyridine Janus kinase 2 inhibitors.
J Med Chem
; 54(24): 8440-50, 2011 Dec 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-22087750
18.
Discovery and optimization of a novel series of N-arylamide oxadiazoles as potent, highly selective and orally bioavailable cannabinoid receptor 2 (CB2) agonists.
J Med Chem
; 51(16): 5019-34, 2008 Aug 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-18680277
19.
Discovery of novel 2,3-diarylfuro[2,3-b]pyridin-4-amines as potent and selective inhibitors of Lck: synthesis, SAR, and pharmacokinetic properties.
Bioorg Med Chem Lett
; 17(8): 2299-304, 2007 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17276681
20.
Discovery of 4-amino-5,6-biaryl-furo[2,3-d]pyrimidines as inhibitors of Lck: development of an expedient and divergent synthetic route and preliminary SAR.
Bioorg Med Chem Lett
; 17(8): 2305-9, 2007 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17280833